Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer).
Archaeal genomics is a scientific discipline that concerns the genome, encompassing the entire hereditary information, of Archaea, a domain of organisms consisting of single, nucleus-free cells, distinct from bacteria and eukaryotes.
Methanonatronarchaeia are a distinct class-level lineage of extremely halophilic methanogens, which lack features of classical methanogenesis and have a high intracellular concentration of potassium, suggesting potassium-based osmoprotection.
Archaea are highly diverse microorganisms that inhabit various environments. This evolutionary flexibility and adaptability has been supported by abundant horizontal gene transfer. In this Review, Albers and colleagues discuss the mechanisms and consequences of archaeal DNA transfer.
Diversity-generating retroelements are abundant in the reduced genomes of bacteria and archaea belonging to the CPR and DPANN phyla, driving hypervariability on proteins involved in signalling, transcriptional regulation, attachment and defence.