Archaeal genetics

Archaeal genetics is the scientific study of the genes, consisting of hereditary units, of Archaea, a domain of organisms that comprise single, nucleus-free cells, distinct from bacteria and eukaryotes.

Latest Research and Reviews

  • Reviews |

    Methane metabolism has a central role in the global carbon cycle. In the Review, Tyson and colleagues discuss the enzymatic pathways responsible for archaeal methane metabolism and highlight the evolutionary relationships of key enzymes with recently discovered alkane-oxidizing archaea.

    • Paul N. Evans
    • , Joel A. Boyd
    • , Andy O. Leu
    • , Ben J. Woodcroft
    • , Donovan H. Parks
    • , Philip Hugenholtz
    •  & Gene W. Tyson
  • Reviews |

    Prokaryotic Argonaute proteins, homologues of eukaryotic Argonaute proteins involved in RNA interference, have recently been demonstrated to mediate host defence in archaea and bacteria. In this Progress article, van der Oost and colleagues explore the structures and biological functions of the prokaryotic Argonaute proteins, and discuss their potential applications in genome editing.

    • Jorrit W. Hegge
    • , Daan C. Swarts
    •  & John van der Oost
  • Reviews |

    Archaea are highly diverse microorganisms that inhabit various environments. This evolutionary flexibility and adaptability has been supported by abundant horizontal gene transfer. In this Review, Albers and colleagues discuss the mechanisms and consequences of archaeal DNA transfer.

    • Alexander Wagner
    • , Rachel J. Whitaker
    • , David J. Krause
    • , Jan-Hendrik Heilers
    • , Marleen van Wolferen
    • , Chris van der Does
    •  & Sonja-Verena Albers
  • Research |

    In bacteria and archaea, CRISPR-Cas adaptive immune systems utilize RNA-guided endonucleases to defend against invasion by foreign nucleic acids of bacteriophage, virus and plasmid origin. In a recent paper published in Nature, Burstein et al. identified the first Cas9 protein in uncultivated archaea and two novel CRISPR-CasX and CRISPR-CasY systems in uncultivated bacteria by capitalizing on analysis of terabase-scale metagenomic datasets from natural uncultivated organisms.

    • Hui Yang
    •  & Dinshaw J Patel
    Cell Research 27, 313-314

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