Applied immunology articles within Nature Communications

Featured

  • Article
    | Open Access

    Ageing is associated with poor responses to vaccines but the underlying mechanism remains unclear. Here the authors use a systems-based approach to define molecular signatures present before vaccination that correlate with non-responsiveness to hepatitis B vaccination in healthy, elderly adults.

    • Slim Fourati
    • , Razvan Cristescu
    •  & Rafick-Pierre Sékaly

  • Article
    | Open Access

    Respiratory syncytial virus (RSV) is a highly contagious childhood pathogen of the respiratory tract for which no vaccine is currently available. Here the authors present a strategy to stabilize the RSV F protein in a prefusion conformation that can elicit a strong protective immune response in animal models.

    • Anders Krarup
    • , Daphné Truan
    •  & Johannes P. M. Langedijk

  • Article
    | Open Access

    The availability of high-yield virus strains remains an important bottleneck in the rapid production of influenza vaccines. Here, the authors report the development of influenza A vaccine backbone that improves the virus yield of various seasonal and pandemic influenza vaccine strains in cell culture.

    • Jihui Ping
    • , Tiago J.S. Lopes
    •  & Yoshihiro Kawaoka

  • Article
    | Open Access

    Unmet need exists for a vaccine against Middle East respiratory syndrome coronavirus (MERS-CoV). Here the authors report the establishment and evaluation, in mice and primates, of a series of MERS-CoV immunogens and show that they can serve as promising leads for vaccine development.

    • Lingshu Wang
    • , Wei Shi
    •  & Barney S. Graham

  • Article
    | Open Access

    Monoclonal antibodies with broadly neutralizing activity are being developed as potential treatment of influenza infections. Here, the authors describe a broadly neutralizing antibody with an unusual mode of binding to viral haemagglutinin, which has been isolated from patients convalescent from pandemic H1N1 influenza infection.

    • Ying Wu
    • , MyungSam Cho
    •  & Ruben O. Donis

  • Article
    | Open Access

    HIV vaccine development will be facilitated by having animal models that are predictive for translation to humans. Here, the authors use two nonhuman primate models to compare the effects of natural infection and different adjuvants on antigen persistence, diversity and humoral immunity.

    • Joseph R. Francica
    • , Zizhang Sheng
    •  & Robert A. Seder

  • Article
    | Open Access

    Protein scaffolds can serve as alternatives to antibodies in a range of applications. Here, the authors report the design and development of Alphabody™, a protein scaffold featuring a single-chain antiparallel triple-helix coiled-coil fold that the authors use to develop Alphabodies that can neutralize human IL-23 with high specificity and affinity.

    • Johan Desmet
    • , Kenneth Verstraete
    •  & Savvas N. Savvides

  • Article
    | Open Access

    While several human papilloma virus (HPV) vaccines exist, a highly effective vaccine that mediates regression of HPV-induced tumours is lacking. Here the authors show that a therapeutic DNA vaccine-induced HPV-specific polyfunctional CD8 T cell in 7 out of 9 patients who all exhibited complete regression of lesions and viral clearance.

    • Tae Jin Kim
    • , Hyun-Tak Jin
    •  & Young Chul Sung

  • Article |

    Health monitoring based on measuring circulating antibodies may enable the presymptomatic detection of diseases. Here, the authors report a large-scale peptide array platform that allows for a detection of the profile of circulating antibodies associated with cancers and infectious diseases.

    • Joseph Barten Legutki
    • , Zhan-Gong Zhao
    •  & Phillip Stafford

  • Article |

    Antibody–antigen recognition is one of the important aspects of immunity, but the nanomechanical process of this recognition is not fully understood. Here, using high-speed atomic force microscopy, the authors observe that on membranes containing a high density of immobile antigens antibodies move in a ‘random walking’ motion.

    • Johannes Preiner
    • , Noriyuki Kodera
    •  & Peter Hinterdorfer

  • Article |

    Bacterial type III secretion systems (T3SS) improve the delivery of vaccine antigens and antigen-specific immune responses but require the use of live vaccines. Carleton et al. report the assembly of a functional T3SS in replication-incompetent bacterial minicells that can deliver vaccine antigens in vitro and in vivo.

    • Heather A. Carleton
    • , María Lara-Tejero
    •  & Jorge E. Galán

Browse broader subjects

Browse narrower subjects

Browse Applied immunology across other nature.com journals