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We characterize the activity of fluorofolin, a potent inhibitor of dihydrofolate reductase, against Pseudomonas aeruginosa. By exploiting a divergence in thymidine metabolism, fluorofolin becomes selective for P. aeruginosa in the presence of thymine, demonstrating that it can be a narrow-spectrum antibiotic for this bacterial pathogen.
We found trade-offs among the environmental and animal welfare impacts of pig farms — those that had low greenhouse gas emissions typically had low land use but poor animal welfare and high antimicrobial use. Some farms performed well in all four impacts, but these farms were not consistently associated with any particular farm or label type.
Shi et al. describe a phenotypic, culture-free platform that completes the diagnosis of bloodstream infections about 15 hours faster than standard diagnostic technologies. Results from clinical blood samples that demonstrate near real-time diagnostic information suitable for clinicians is provided.
Here, the authors structurally and functionally characterise DltB, a member of the Membrane-Bound O-AcylTransferase (MBOAT) superfamily responsible for D-alanine incorporation in the cell wall of gram-positive bacteria.
Antibiotics to treat carbapenem-resistant Acinetobacter baumannii infection are an urgent need. The cerastecins are potent, bactericidal and efficacious in animal models of infection, and may enable new treatment modalities targeting LOS transport.
We characterize the activity of fluorofolin, a potent inhibitor of dihydrofolate reductase, against Pseudomonas aeruginosa. By exploiting a divergence in thymidine metabolism, fluorofolin becomes selective for P. aeruginosa in the presence of thymine, demonstrating that it can be a narrow-spectrum antibiotic for this bacterial pathogen.
We found trade-offs among the environmental and animal welfare impacts of pig farms — those that had low greenhouse gas emissions typically had low land use but poor animal welfare and high antimicrobial use. Some farms performed well in all four impacts, but these farms were not consistently associated with any particular farm or label type.
Researchers developed an AI model that designs novel, synthesizable antibiotic compounds — several of which showed potent in vitro activity against priority pathogens.
In this study, Liu et al. explore the interplay between a fungal effector and a plant cysteine protease and design a small-molecule compound aimed at targeting this effector to combat rice blast disease.