Antigen processing and presentation

Antigen processing and presentation is the process by which protein antigen is ingested by an antigen-presenting cell (APC), partially digested into peptide fragments and then displayed on the surface of the APC associated with an antigen-presenting molecule such as MHC class I or MHC class II, for recognition by certain lymphocytes such as T cells.

Latest Research and Reviews

  • Research | | open

    Gut lumen antigens must be continuously sampled by the immune system to maintain proper immune homeostasis. Here the authors show that activated CCR6+CCR1+GL7- gut B cells retrieve lumen antigens from specialized M cells and transfer them across the subepithelial dome in the Peyer’s patch to contribute to the maintenance of gut humoral immunity.

    • Rathan Joy Komban
    • , Anneli Strömberg
    • , Adi Biram
    • , Jakob Cervin
    • , Cristina Lebrero-Fernández
    • , Neil Mabbott
    • , Ulf Yrlid
    • , Ziv Shulman
    • , Mats Bemark
    •  & Nils Lycke
  • Research |

    Many tumors evade immunosurveillance by down-modulating expression of antigen-processing machinery and MHC molecules. Yang et al. report triple-negative tumor cell expression of the lncRNA LINK-A enhances degradation of antigen peptide-loading complex molecules and intrinsic tumor suppressors, which contribute to tumor persistence.

    • Qingsong Hu
    • , Youqiong Ye
    • , Li-Chuan Chan
    • , Yajuan Li
    • , Ke Liang
    • , Aifu Lin
    • , Sergey D. Egranov
    • , Yaohua Zhang
    • , Weiya Xia
    • , Jing Gong
    • , Yinghong Pan
    • , Sujash S. Chatterjee
    • , Jun Yao
    • , Kurt W. Evans
    • , Tina K. Nguyen
    • , Peter K. Park
    • , Jiewei Liu
    • , Cristian Coarfa
    • , Sri Ramya Donepudi
    • , Vasanta Putluri
    • , Nagireddy Putluri
    • , Arun Sreekumar
    • , Chandrashekar R. Ambati
    • , David H. Hawke
    • , Jeffrey R. Marks
    • , Preethi H. Gunaratne
    • , Abigail S. Caudle
    • , Aysegul A. Sahin
    • , Gabriel N. Hortobagyi
    • , Funda Meric-Bernstam
    • , Lieping Chen
    • , Dihua Yu
    • , Mien-Chie Hung
    • , Michael A. Curran
    • , Leng Han
    • , Chunru Lin
    •  & Liuqing Yang
  • Research | | open

    Both thymic epithelial cells and dendritic cells present self antigens in the thymus to mediate thymic selection and T cell tolerance. Here the authors quantify, using two-photon live imaging of mouse thymic slices, the relative contribution of these two cell types, as well as the effects of antigen cross-presentation by dendritic cells, during tolerance induction.

    • J. N. Lancaster
    • , H. M. Thyagarajan
    • , J. Srinivasan
    • , Y. Li
    • , Z. Hu
    •  & L. I. R. Ehrlich
  • Research |

    Type 1 diabetes (T1D) involves immune-mediated destruction of pancreatic β cells. Here, the authors show that inducing β-cell replication before immune cell infiltration of the pancreas alters β-cell antigen expression and prevents T1D disease progression in female NOD mice in a regulatory-T-cell-dependent manner.

    • Ercument Dirice
    • , Sevim Kahraman
    • , Dario F. De Jesus
    • , Abdelfattah El Ouaamari
    • , Giorgio Basile
    • , Rocky L. Baker
    • , Burcu Yigit
    • , Paul D. Piehowski
    • , Mi-Jeong Kim
    • , Alexander J. Dwyer
    • , Raymond W. S. Ng
    • , Cornelia Schuster
    • , Heidrun Vethe
    • , Tijana Martinov
    • , Yuki Ishikawa
    • , Adrian Kee Keong Teo
    • , Richard D. Smith
    • , Jiang Hu
    • , Kathryn Haskins
    • , Thomas Serwold
    • , Wei-Jun Qian
    • , Brian T. Fife
    • , Stephan Kissler
    •  & Rohit N. Kulkarni
    Nature Metabolism 1, 509-518

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