Antigen processing and presentation

Antigen processing and presentation is the process by which protein antigen is ingested by an antigen-presenting cell (APC), partially digested into peptide fragments and then displayed on the surface of the APC associated with an antigen-presenting molecule such as MHC class I or MHC class II, for recognition by certain lymphocytes such as T cells.

Latest Research and Reviews

  • Research | | open

    Anti-human leukocyte antigen (HLA) antibodies are important mediators of alloresponses, but structural insights on antibody:HLA interaction are still lacking. Here the authors provide a 2.4 Å structure of antibody:HLA complex, and also analyse HLA features important for other HLA-interacting molecules, to enhance our understanding of alloimmunity.

    • Yue Gu
    • , Yee Hwa Wong
    • , Chong Wai Liew
    • , Conrad E. Z. Chan
    • , Tanusya M. Murali
    • , Jiawei Yap
    • , Chien Tei Too
    • , Kiren Purushotorman
    • , Maryam Hamidinia
    • , Abbas El Sahili
    • , Angeline T. H. Goh
    • , Rachel Z. C. Teo
    • , Kathryn J. Wood
    • , Brendon J. Hanson
    • , Nicholas R. J. Gascoigne
    • , Julien Lescar
    • , Anantharaman Vathsala
    •  & Paul A. MacAry
  • Research | | open

    Microfold cells (M-cell) are specialized cells of the intestine that sample luminal microbiota and dietary antigens. Here the authors show that epithelial non-canonical NFκB signalling, as induced by NIK, is important for M-cells maintenance, yet constitutive NIK activation is associated with gut inflammation and inflammatory bowel disease.

    • Sadeesh K. Ramakrishnan
    • , Huabing Zhang
    • , Xiaoya Ma
    • , Inkyung Jung
    • , Andrew J. Schwartz
    • , Daniel Triner
    • , Samantha N. Devenport
    • , Nupur K. Das
    • , Xiang Xue
    • , Melody Y. Zeng
    • , Yinling Hu
    • , Richard M. Mortensen
    • , Joel K Greenson
    • , Marilia Cascalho
    • , Christiane E. Wobus
    • , Justin A. Colacino
    • , Gabriel Nunez
    • , Liangyou Rui
    •  & Yatrik M. Shah
  • Research |

    Engineered, bifunctional receptors present antigens and initiate signaling in response to binding to the cognate T cell receptor. Libraries built with SABRs can screen thousands of epitopes for the discovery of T cell target antigens.

    • Alok V. Joglekar
    • , Michael T. Leonard
    • , John D. Jeppson
    • , Margaret Swift
    • , Guideng Li
    • , Stephanie Wong
    • , Songming Peng
    • , Jesse M. Zaretsky
    • , James R. Heath
    • , Antoni Ribas
    • , Michael T. Bethune
    •  & David Baltimore
    Nature Methods 16, 191-198
  • Research |

    Trogocytosis, the uptake of membrane proteins by an antigen-presenting cell from its cognate T cell, allows the identification of neoepitopes targeted by T cell receptors with high sensitivity.

    • Guideng Li
    • , Michael T. Bethune
    • , Stephanie Wong
    • , Alok V. Joglekar
    • , Michael T. Leonard
    • , Jessica K. Wang
    • , Jocelyn T. Kim
    • , Donghui Cheng
    • , Songming Peng
    • , Jesse M. Zaretsky
    • , Yapeng Su
    • , Yicheng Luo
    • , James R. Heath
    • , Antoni Ribas
    • , Owen N. Witte
    •  & David Baltimore
    Nature Methods 16, 183-190

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