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Effectors secreted by plant pathogens subvert host immunity. Here the authors use a structural approach to design a small molecule that can disrupt the interaction between a fungal effector and its target in rice, and could be used as a novel fungicide.
Brain glucose induces in vivo tolerance of Cryptococcus neoformans to amphotericin B, limiting fungicidal efficacy against meningitis in a mouse model, and aureobasidin A inhibits brain glucose-induced tolerance, improving therapeutic outcome.
In this study, Liu et al. explore the interplay between a fungal effector and a plant cysteine protease and design a small-molecule compound aimed at targeting this effector to combat rice blast disease.
Invasive fungal diseases are on the increase globally. The World Health Organization fungal priority pathogens list highlights fungi of critical or high importance to human health and provides pathways for action. The report calls for improved surveillance (diagnostics and antifungal resistance monitoring), research and innovation (implementation research) and public-health interventions.
This study describes the isolation of a new compound, turbinmicin, which shows potent activity in mice against multidrug-resistant fungi and might have a novel mechanism of action.
This study reports that extensive copy number variations occur in the presence of azole antifungal drugs in Candida albicans, which might cause phenotypic and population-level heterogeneity observed in clinical isolates.
