Antibodies

Antibodies are secreted immunoglobulin molecules produced mainly by plasma cells. The antigen-binding site of the antibody has a unique structure that allows it to bind antigen in a highly specific manner.

Latest Research and Reviews

  • Research |

    In a mouse model of herpes simplex 2 virus infection, circulating memory B cells—rather than plasma cells—are shown to be the source of antibody secretion in the vaginal lumen following secondary infection.

    • Ji Eun Oh
    • , Norifumi Iijima
    • , Eric Song
    • , Peiwen Lu
    • , Jonathan Klein
    • , Ruoyi Jiang
    • , Steven H. Kleinstein
    •  & Akiko Iwasaki
    Nature, 1-5
  • Research | | open

    Phosphatase of regenerating liver 3 (PRL3) is usually found intracellularly, and is over-expressed in cancer cells. Here the authors show that PRL-3 is also detectable on cell surface, and can be recognized by PRL3-zumab to recruit immune cells into tumor to promote anti-tumor immunity, thereby implicating PRL-3 as a potential tumor antigen.

    • Min Thura
    • , Abdul Qader Al-Aidaroos
    • , Abhishek Gupta
    • , Cheng Ean Chee
    • , Soo Chin Lee
    • , Kam Man Hui
    • , Jie Li
    • , Yeoh Khay Guan
    • , Wei Peng Yong
    • , Jimmy So
    • , Wee Joo Chng
    • , Chin Hin Ng
    • , Jianbiao Zhou
    • , Ling Zhi Wang
    • , John Shyi Peng Yuen
    • , Henry Sun Sien Ho
    • , Sim Mei Yi
    • , Edmund Chiong
    • , Su Pin Choo
    • , Joanne Ngeow
    • , Matthew Chau Hsien Ng
    • , Clarinda Chua
    • , Eugene Shen Ann Yeo
    • , Iain Bee Huat Tan
    • , Joel Xuan En Sng
    • , Nicholas Yan Zhi Tan
    • , Jean Paul Thiery
    • , Boon Cher Goh
    •  & Qi Zeng
  • Research | | open

    Gut lumen antigens must be continuously sampled by the immune system to maintain proper immune homeostasis. Here the authors show that activated CCR6+CCR1+GL7- gut B cells retrieve lumen antigens from specialized M cells and transfer them across the subepithelial dome in the Peyer’s patch to contribute to the maintenance of gut humoral immunity.

    • Rathan Joy Komban
    • , Anneli Strömberg
    • , Adi Biram
    • , Jakob Cervin
    • , Cristina Lebrero-Fernández
    • , Neil Mabbott
    • , Ulf Yrlid
    • , Ziv Shulman
    • , Mats Bemark
    •  & Nils Lycke
  • Research |

    Study of influenza virus transmission in humans provides evidence that hemagglutinin stalk-specific antibodies correlate with protection from infection.

    • Sophia Ng
    • , Raffael Nachbagauer
    • , Angel Balmaseda
    • , Daniel Stadlbauer
    • , Sergio Ojeda
    • , Mayuri Patel
    • , Arvind Rajabhathor
    • , Roger Lopez
    • , Andrea F. Guglia
    • , Nery Sanchez
    • , Fatima Amanat
    • , Lionel Gresh
    • , Guillermina Kuan
    • , Florian Krammer
    •  & Aubree Gordon
    Nature Medicine 25, 962-967
  • Research | | open

    Stabilized, native-like trimers of the HIV envelope protein, such as SOSIP trimers, are potential antigens for an HIV vaccine. Here, the authors generate a SOSIP trimer based on the consensus sequence of group M isolates, determine its structure and exposure of common epitopes, and show immunogenicity in rabbits and non-human primates.

    • Kwinten Sliepen
    • , Byung Woo Han
    • , Ilja Bontjer
    • , Petra Mooij
    • , Fernando Garces
    • , Anna-Janina Behrens
    • , Kimmo Rantalainen
    • , Sonu Kumar
    • , Anita Sarkar
    • , Philip J. M. Brouwer
    • , Yuanzi Hua
    • , Monica Tolazzi
    • , Edith Schermer
    • , Jonathan L. Torres
    • , Gabriel Ozorowski
    • , Patricia van der Woude
    • , Alba Torrents de la Peña
    • , Mariëlle J. van Breemen
    • , Juan Miguel Camacho-Sánchez
    • , Judith A. Burger
    • , Max Medina-Ramírez
    • , Nuria González
    • , Jose Alcami
    • , Celia LaBranche
    • , Gabriella Scarlatti
    • , Marit J. van Gils
    • , Max Crispin
    • , David C. Montefiori
    • , Andrew B. Ward
    • , Gerrit Koopman
    • , John P. Moore
    • , Robin J. Shattock
    • , Willy M. Bogers
    • , Ian A. Wilson
    •  & Rogier W. Sanders
  • Research | | open

    New immune biomarkers of exposure to tuberculosis may require a rethink of evidence of Mycobacterium tuberculosis infection and control.

    • Lenette L. Lu
    • , Malisa T. Smith
    • , Krystle K. Q. Yu
    • , Corinne Luedemann
    • , Todd J. Suscovich
    • , Patricia S. Grace
    • , Adam Cain
    • , Wen Han Yu
    • , Tanya R. McKitrick
    • , Douglas Lauffenburger
    • , Richard D. Cummings
    • , Harriet Mayanja-Kizza
    • , Thomas R. Hawn
    • , W. Henry Boom
    • , Catherine M. Stein
    • , Sarah M. Fortune
    • , Chetan Seshadri
    •  & Galit Alter
    Nature Medicine 25, 977-987

News and Comment