Antibodies

Antibodies are secreted immunoglobulin molecules produced mainly by plasma cells. The antigen-binding site of the antibody has a unique structure that allows it to bind antigen in a highly specific manner.

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Latest Research and Reviews

  • Research | | open

    Orthobunyaviruses (OBVs) cause severe disease in humans and farm animals, but the molecular basis for infection is not fully understood. Here, the authors present crystal structures of free and antibody-bound OBV envelope glycoproteins and show that their domains enable efficient immunization in a mouse model.

    • Jan Hellert
    • , Andrea Aebischer
    • , Kerstin Wernike
    • , Ahmed Haouz
    • , Emiliana Brocchi
    • , Sven Reiche
    • , Pablo Guardado-Calvo
    • , Martin Beer
    •  & Félix A. Rey
  • Research |

    Antigenic variation of influenza A viruses necessitates the annual reformulation of vaccines. Kanekiyo et al. develop a mosaic nanoparticle vaccine against influenza virus that is able to elicit neutralizing antibodies that span nearly 100 years of variation of influenza A virus.

    • Masaru Kanekiyo
    • , M. Gordon Joyce
    • , Rebecca A. Gillespie
    • , John R. Gallagher
    • , Sarah F. Andrews
    • , Hadi M. Yassine
    • , Adam K. Wheatley
    • , Brian E. Fisher
    • , David R. Ambrozak
    • , Adrian Creanga
    • , Kwanyee Leung
    • , Eun Sung Yang
    • , Seyhan Boyoglu-Barnum
    • , Ivelin S. Georgiev
    • , Yaroslav Tsybovsky
    • , Madhu S. Prabhakaran
    • , Hanne Andersen
    • , Wing-Pui Kong
    • , Ulrich Baxa
    • , Kathryn L. Zephir
    • , Julie E. Ledgerwood
    • , Richard A. Koup
    • , Peter D. Kwong
    • , Audray K. Harris
    • , Adrian B. McDermott
    • , John R. Mascola
    •  & Barney S. Graham
    Nature Immunology 20, 362-372
  • Research | | open

    Somatic mutations within antibody framework regions (FWR) can alter structural flexibility, but their role in maturation of broadly neutralizing antibodies (bnAbs) is unclear. Here the authors show how FWR mutations impact interdomain conformational flexibility and paratope plasticity during bnAb development.

    • Rory Henderson
    • , Brian E. Watts
    • , Hieu N. Ergin
    • , Kara Anasti
    • , Robert Parks
    • , Shi-Mao Xia
    • , Ashley Trama
    • , Hua-Xin Liao
    • , Kevin O. Saunders
    • , Mattia Bonsignori
    • , Kevin Wiehe
    • , Barton F. Haynes
    •  & S. Munir Alam
  • Research | | open

    High-throughput sequencing and analyzes of antibody repertoire provide important information on immune responses, but current methodologies are limited in sequence assembly precision and haplotype inference validity. Here the authors propose a new Bayesian haplotyping method, and attest its broad application with a large, multi-individual dataset.

    • Moriah Gidoni
    • , Omri Snir
    • , Ayelet Peres
    • , Pazit Polak
    • , Ida Lindeman
    • , Ivana Mikocziova
    • , Vikas Kumar Sarna
    • , Knut E. A. Lundin
    • , Christopher Clouser
    • , Francois Vigneault
    • , Andrew M. Collins
    • , Ludvig M. Sollid
    •  & Gur Yaari
  • Research | | open

    Antibodies against Plasmodium falciparum merozoites that fix complement can inhibit blood-stage replication. Here, Reiling et al. show that complement-fixing antibodies strongly correlate with protective immunity in children, identify the merozoite targets, and predict antigen combinations that should result in strong protection.

    • Linda Reiling
    • , Michelle J. Boyle
    • , Michael T. White
    • , Danny W. Wilson
    • , Gaoqian Feng
    • , Rupert Weaver
    • , D. Herbert Opi
    • , Kristina E. M. Persson
    • , Jack S. Richards
    • , Peter M. Siba
    • , Freya J. I. Fowkes
    • , Eizo Takashima
    • , Takafumi Tsuboi
    • , Ivo Mueller
    •  & James G. Beeson

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