Antibacterial drug resistance

Definition

Antibacterial drug resistance is the process that bacteria use to tolerate and overcome the effects of antibiotic drugs. Resistance can arise through mutations or can be acquired from other bacteria through plasmids.

Latest Research and Reviews

  • Research | | open

    Transcription factors MarR and MarA confer multidrug resistance in enteric bacteria by modulating efflux pump and porin expression. Here, Sharma et al. show that MarA also upregulates genes required for lipid trafficking and DNA repair, thus reducing antibiotic entry and quinolone-induced DNA damage.

    • Prateek Sharma
    • , James R. J. Haycocks
    • , Alistair D. Middlemiss
    • , Rachel A. Kettles
    • , Laura E. Sellars
    • , Vito Ricci
    • , Laura J. V. Piddock
    •  & David C. Grainger
  • Reviews |

    Many bacteria can infect and persist inside their hosts for long periods of time. In this Review, Fisher, Gollan and Helaine discuss recent developments in our understanding of bacterial persisters and their potential implications for the treatment of persistent infections.

    • Robert A. Fisher
    • , Bridget Gollan
    •  & Sophie Helaine
  • Research | | open

    The mechanisms of action of the antibacterial metalloid tellurite are unclear. Here, the authors show that tellurite induces an accumulation of hydroxyl radical and intermediates of heme biosynthesis in E. coli, and that the heme precursor 5-aminolevulinic acid potentiates tellurite toxicity.

    • Eduardo H. Morales
    • , Camilo A. Pinto
    • , Roberto Luraschi
    • , Claudia M. Muñoz-Villagrán
    • , Fabián A. Cornejo
    • , Scott W. Simpkins
    • , Justin Nelson
    • , Felipe A. Arenas
    • , Jeff S. Piotrowski
    • , Chad L. Myers
    • , Hirotada Mori
    •  & Claudio C. Vásquez
  • Reviews |

    Timely and accurate identification and determination of the antimicrobial susceptibility of uropathogens is central to the management of UTIs and antimicrobial stewardship. In this Review, Davenport and colleagues discuss emerging technologies including biosensors, microfluidics, and other integrated platforms that could improve UTI diagnosis and treatment choice.

    • Michael Davenport
    • , Kathleen E. Mach
    • , Linda M. Dairiki Shortliffe
    • , Niaz Banaei
    • , Tza-Huei Wang
    •  & Joseph C. Liao
  • Reviews |

    Gonorrhoea and Mycoplasma genitalium infections are evolving to be exceedingly difficult to treat or untreatable. Unemo and Jensen provide an overview and discussion of prevalence data, diagnostics, current treatment recommendations and potential future therapies of these infections, highlighting priorities to retain their treatability.

    • Magnus Unemo
    •  & Jorgen S. Jensen

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