Anatomy

Definition

Anatomy is the field of biology that studies the structure of living things. Anatomy focuses on the composition, structure and location of the parts of organisms – tissues, organs and systems – as well as the relationships between different parts.

Latest Research and Reviews

  • Reviews |

    Hepatitis E virus (HEV) is a public health concern in both developing and developed countries. Here, the authors describe advances in understanding HEV biology, clinical infection and the challenges still to be overcome in HEV research, particularly with respect to cell culture and animal models.

    • Ila Nimgaonkar
    • , Qiang Ding
    • , Robert E. Schwartz
    •  & Alexander Ploss
  • Research | | open

    Heligmosomoides polygyrus can activate mammalian TGF-β signalling pathways, but how it does so is not known. Here the authors identify and isolate a H. polygyrus TFG-β mimic that can bind both mammalian TGF-β receptor subunits, activate Smad signalling and generate inducible regulatory T cells.

    • Chris J. C. Johnston
    • , Danielle J. Smyth
    • , Ravindra B. Kodali
    • , Madeleine P. J. White
    • , Yvonne Harcus
    • , Kara J. Filbey
    • , James P. Hewitson
    • , Cynthia S. Hinck
    • , Alasdair Ivens
    • , Andrea M. Kemter
    • , Anna O. Kildemoes
    • , Thierry Le Bihan
    • , Dinesh C. Soares
    • , Stephen M. Anderton
    • , Thomas Brenn
    • , Stephen J. Wigmore
    • , Hannah V. Woodcock
    • , Rachel C. Chambers
    • , Andrew P. Hinck
    • , Henry J. McSorley
    •  & Rick M. Maizels
  • Research | | open

    Glucocorticoid reduces inflammation by both inducing anti-inflammatory genes and suppressing pro-inflammatory genes, but how these two functions are dictated is unclear. Here the authors show that phosphorylated glucocorticoid receptor-interacting protein 1 (GRIP1) serves as a coactivator for this response in macrophage.

    • David A. Rollins
    • , Joubert B. Kharlyngdoh
    • , Maddalena Coppo
    • , Bowranigan Tharmalingam
    • , Sanda Mimouna
    • , Ziyi Guo
    • , Maria A. Sacta
    • , Miles A. Pufall
    • , Robert P. Fisher
    • , Xiaoyu Hu
    • , Yurii Chinenov
    •  & Inez Rogatsky
  • Research | | open

    The transplantation of tissue-specific progenitor cells may be an approach in organ regeneration. Here the authors show that the nephron progenitor population of a developing mouse kidney, when ablated, can be replaced by exogenously supplied rat nephron progenitors, generating interspecies nephrons.

    • S. Yamanaka
    • , S. Tajiri
    • , T. Fujimoto
    • , K. Matsumoto
    • , S. Fukunaga
    • , B. S. Kim
    • , H. J. Okano
    •  & T. Yokoo
  • Research | | open

    An efficient HIV-1 vaccine will likely depend on eliciting broadly neutralizing antibodies (bnAb). Here the authors analyze the B cell repertoire in macaques and knock-in mice in response to sequential immunization with Env variants that induce a bnAb targeting the CD4-binding site of Env in a HIV-1 infected individual.

    • Wilton B. Williams
    • , Jinsong Zhang
    • , Chuancang Jiang
    • , Nathan I. Nicely
    • , Daniela Fera
    • , Kan Luo
    • , M. Anthony Moody
    • , Hua-Xin Liao
    • , S. Munir Alam
    • , Thomas B. Kepler
    • , Akshaya Ramesh
    • , Kevin Wiehe
    • , James A. Holland
    • , Todd Bradley
    • , Nathan Vandergrift
    • , Kevin O. Saunders
    • , Robert Parks
    • , Andrew Foulger
    • , Shi-Mao Xia
    • , Mattia Bonsignori
    • , David C. Montefiori
    • , Mark Louder
    • , Amanda Eaton
    • , Sampa Santra
    • , Richard Scearce
    • , Laura Sutherland
    • , Amanda Newman
    • , Hilary Bouton-Verville
    • , Cindy Bowman
    • , Howard Bomze
    • , Feng Gao
    • , Dawn J. Marshall
    • , John F. Whitesides
    • , Xiaoyan Nie
    • , Garnett Kelsoe
    • , Steven G. Reed
    • , Christopher B. Fox
    • , Kim Clary
    • , Marguerite Koutsoukos
    • , David Franco
    • , John R. Mascola
    • , Stephen C. Harrison
    • , Barton F. Haynes
    •  & Laurent Verkoczy

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