Amyotrophic lateral sclerosis

Definition

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder that is marked by fasciculation, spasticity and progressive weakness of muscles, and results in difficulty speaking, swallowing and breathing. ALS is fatal, usually leading to death within a few years from diagnosis, although more slowly progressing forms of the disease exist.

Latest Research and Reviews

  • Research |

    Antisense oligonucleotides against ATXN2 improved motor neuron function and restored firing frequency in cerebellar Purkinje cells in mouse models of spinocerebellar ataxia type 2.

    • Daniel R. Scoles
    • , Pratap Meera
    • , Matthew D. Schneider
    • , Sharan Paul
    • , Warunee Dansithong
    • , Karla P. Figueroa
    • , Gene Hung
    • , Frank Rigo
    • , C. Frank Bennett
    • , Thomas S. Otis
    •  & Stefan M. Pulst
    Nature 544, 362–366
  • Research | | open

    Relatives of patients with amyotrophic lateral sclerosis have an unexpectedly high incidence of schizophrenia. Here, the authors show a genetic link between the two conditions, suggesting shared neurobiological mechanisms.

    • Russell L. McLaughlin
    • , Dick Schijven
    • , Wouter van Rheenen
    • , Kristel R. van Eijk
    • , Margaret O’Brien
    • , René S. Kahn
    • , Roel A. Ophoff
    • , An Goris
    • , Daniel G. Bradley
    • , Ammar Al-Chalabi
    • , Leonard H. van den Berg
    • , Jurjen J. Luykx
    • , Orla Hardiman
    • , Jan H. Veldink
    • , Project MinE GWAS Consortium
    • , Aleksey Shatunov
    • , Annelot M. Dekker
    • , Frank P. Diekstra
    • , Sara L. Pulit
    • , Rick A. A. van der Spek
    • , Perry T. C. van Doormaal
    • , William Sproviero
    • , Ashley R. Jones
    • , Garth A. Nicholson
    • , Dominic B. Rowe
    • , Roger Pamphlett
    • , Matthew C. Kiernan
    • , Denis Bauer
    • , Tim Kahlke
    • , Kelly Williams
    • , Filip Eftimov
    • , Isabella Fogh
    • , Nicola Ticozzi
    • , Kuang Lin
    • , Stéphanie Millecamps
    • , François Salachas
    • , Vincent Meininger
    • , Mamede de Carvalho
    • , Susana Pinto
    • , Jesus S. Mora
    • , Ricardo Rojas-García
    • , Meraida Polak
    • , Siddharthan Chandran
    • , Shuna Colville
    • , Robert Swingler
    • , Karen E. Morrison
    • , Pamela J. Shaw
    • , John Hardy
    • , Richard W. Orrell
    • , Alan Pittman
    • , Katie Sidle
    • , Pietro Fratta
    • , Andrea Malaspina
    • , Susanne Petri
    • , Susanna Abdulla
    • , Carsten Drepper
    • , Michael Sendtner
    • , Thomas Meyer
    • , Martina Wiedau-Pazos
    • , Catherine Lomen-Hoerth
    • , Vivianna M. Van Deerlin
    • , John Q. Trojanowski
    • , Lauren Elman
    • , Leo McCluskey
    • , Nazli Basak
    • , Thomas Meitinger
    • , Peter Lichtner
    • , Milena Blagojevic-Radivojkov
    • , Christian R. Andres
    • , Cindy Maurel
    • , Gilbert Bensimon
    • , Bernhard Landwehrmeyer
    • , Alexis Brice
    • , Christine A. M. Payan
    • , Safa Saker-Delye
    • , Alexandra Dürr
    • , Nicholas Wood
    • , Lukas Tittmann
    • , Wolfgang Lieb
    • , Andre Franke
    • , Marcella Rietschel
    • , Sven Cichon
    • , Markus M. Nöuthen
    • , Philippe Amouyel
    • , Christophe Tzourio
    • , Jean- François Dartigues
    • , Andre G. Uitterlinden
    • , Fernando Rivadeneira
    • , Karol Estrada
    • , Albert Hofman
    • , Charles Curtis
    • , Anneke J. van der Kooi
    • , Marianne de Visser
    • , Markus Weber
    • , Christopher E. Shaw
    • , Bradley N. Smith
    • , Orietta Pansarasa
    • , Cristina Cereda
    • , Roberto Del Bo
    • , Giacomo P. Comi
    • , Stefan Herms
    • , Vera Golimbet
    • , Kenneth L. Davis
    • , Douglas F. Levinson
    • , Bernard Lerer
    • , Ann E. Pulver
    • , Carlos N. Pato
    • , Colm O’Dushlaine
    • , Jonathan Pimm
    • , John Powell
    • , Michael Gill
    • , Nadine Cohen
    • , Diana O. Perkins
    • , Olli Pietiläinen
    • , Igor Nenadic
    • , Jouko Lönnqvist
    • , Srdjan Djurovic
    • , Jacob Gratten
    • , David Cohen
    • , Pak C. Sham
    • , Philippe Corcia
    • , Naomi R. Wray
    • , Hugh Gurling
    • , Patrik K. E. Magnusson
    • , Ayman H. Fanous
    • , Inez Myin-Germeys
    • , Bradley T. Webb
    • , Albert C. Ludolph
    • , Joel N. Hirschhorn
    • , F Anthony O’Neill
    • , Sandra Meier
    • , Ariel Darvasi
    • , Elvira Bramon
    • , Andrew J. Pocklington
    • , Wiepke Cahn
    • , David M. Hougaard
    • , Juha Veijola
    • , Mark Hansen
    • , Bertram Müller-Myhsok
    • , Peter A Holmans
    • , Eli A. Stahl
    • , Dominique Campion
    • , Cathryn M. Lewis
    • , Kenneth S. Kendler
    • , Vaughan J. Carr
    • , Sandra D’Alfonso
    • , Jana Strohmaier
    • , Luba Kalaydjieva
    • , Annette M. Hartmann
    • , Maura Brunetti
    • , Peter Eichhammer
    • , Wei Cheng
    • , Ole Mors
    • , Enrico Domenici
    • , Stephanie H. Witt
    • , Joshua L. Roffman
    • , George Kirov
    • , Claudine Laurent
    • , John Waddington
    • , Michael J. Owen
    • , Brendan Bulik-Sullivan
    • , Eric Y. H. Chen
    • , Jim Van Os
    • , Rodney J. Scott
    • , Ole A. Andreassen
    • , Todd Lencz
    • , Lude Franke
    • , T Scott Stroup
    • , Benjamin M. Neale
    • , Andrea Calvo
    • , Ettore Beghi
    • , Jianxin Shi
    • , Hailiang Huang
    • , Manuel Mattheisen
    • , David Curtis
    • , Tim B. Bigdeli
    • , Stephanie Williams
    • , Dermot Walsh
    • , Tõnu Esko
    • , Madeline Alexander
    • , Federico Casale
    • , Engilbert Sigurdsson
    • , Mythily Subramaniam
    • , Vincenzo Silani
    • , Sibylle G. Schwab
    • , Cinzia Bertolin
    • , Xuebin Zheng
    • , Michael C. O’Donovan
    • , Massimiliano Filosto
    • , John E. Landers
    • , Kang Sim
    • , Morten Mattingsdal
    • , Michele T. Pato
    • , Anil K. Malhotra
    • , Andrea Hofman
    • , Brandon K. Wormley
    • , Valentina Escott-Price
    • , Kristin K. Nicodemus
    • , Kung-Yee Liang
    • , Rosanna Tortelli
    • , Michael A. van Es
    • , Aaron R. Wolen
    • , Liene Nikitina-Zake
    • , Lyudmila Georgieva
    • , Nick Craddock
    • , Wim Robberecht
    • , Guiqing Cai
    • , Philip Van Damme
    • , Johan Eriksson
    • , Jubao Duan
    • , Yunjung Kim
    • , Thomas Werge
    • , Silviu A. Bacanu
    • , Franziska Degenhardt
    • , Adriano Chio
    • , Gerald Nestadt
    • , Ina Giegling
    • , Jochen H. Weishaupt
    • , Naser Durmishi
    • , Tao Li
    • , Raymond C. K. Chan
    • , Antonia Ratti
    • , Carin J. Meijer
    • , Ann Olincy
    • , Jin P. Szatkiewicz
    • , Judit Bene
    • , Masashi Ikeda
    • , Dimitris Dikeos
    • , Brien P. Riley
    • , Line Olsen
    • , C Robert Cloninger
    • , Laurent Essioux
    • , Giulio Genovese
    • , Vahram Haroutunian
    • , Jimmy Lee
    • , Anna K. Kähler
    • , George N. Papadimitriou
    • , Richard Bruggeman
    • , Lieuwe de Haan
    • , Christian Hammer
    • , Nakao Iwata
    • , Elodie Drapeau
    • , Eric Strengman
    • , Timothy Dinan
    • , Mark A. Reimers
    • , Robert W. McCarley
    • , Nancy G. Buccola
    • , Juha Karjalainen
    • , Dragan M. Svrakic
    • , Mads V. Hollegaard
    • , Jan Lubinski
    • , Richard A. Belliveau
    • , Patrick F. Sullivan
    • , Thomas Hansen
    • , Younes Mokrab
    • , Steven A. McCarroll
    • , Letizia Mazzini
    • , Dan Rujescu
    • , Nilo Riva
    • , Sena Karachanak-Yankova
    • , Hannelore Ehrenreich
    • , Preben B. Mortensen
    • , Rita M. Cantor
    • , Phil Lee
    • , Tracey L. Petryshen
    • , William Byerley
    • , Qiang Wang
    • , James J. Crowley
    • , Ulrich Schall
    • , Vaidutis Kucinskas
    • , Ingrid Melle
    • , Lili Milani
    • , Jaana Suvisaari
    • , Rosa Capozzo
    • , Pamela Sklar
    • , Daniel R. Weinberger
    • , Sarah E. Bergen
    • , Danielle Posthuma
    • , Chris C. A. Spencer
    • , Alessandro Padovani
    • , Antonio Julià
    • , Marian L. Hamshere
    • , Emily H. M. Wong
    • , Abraham Reichenberg
    • , Jeffrey Lieberman
    • , Frank Dudbridge
    • , Colm McDonald
    • , Qingqin S. Li
    • , Ronald Y. L. Chan
    • , Ditte Demontis
    • , Viviana Pensato
    • , Menachem Fromer
    • , Gianni Sorarù
    • , Milica Pejovic-Milovancevic
    • , Sergi Papiol
    • , Nelson B. Freimer
    • , Hon-Cheong So
    • , Milan Macek
    • , Christina M. Hultman
    • , Petr Slominsky
    • , Tiina Paunio
    • , Ian Blair
    • , Jurgen Del Favero
    • , Kari Stefansson
    • , S Hong Lee
    • , Bryan J. Mowry
    • , Erik G. Jönsson
    • , Stanley V. Catts
    • , Veikko Salomaa
    • , Alan R. Sanders
    • , Panos Roussos
    • , Simon Arcuti
    • , Jianjun Liu
    • , Edward M. Scolnick
    • , Wolfgang Maier
    • , Thomas G. Schulze
    • , Cinzia Tiloca
    • , Stephanie Godard
    • , Frans A. Henskens
    • , James A. Knowles
    • , Srinivas Thirumalai
    • , Teimuraz Silagadze
    • , James L. Kennedy
    • , Rolf Adolfsson
    • , Hreinn Stefansson
    • , Peter M. Visscher
    • , Jordan W. Smoller
    • , David Kavanagh
    • , Stephan Ripke
    • , Bettina Konte
    • , Ingrid Agartz
    • , Sara Marsal
    • , Paola Giusti-Rodríguez
    • , P Nigel Leigh
    • , Elisabetta Pupillo
    • , Giancarlo Logroscino
    • , Jennifer L. Moran
    • , Clement C. Zai
    • , Digby Quested
    • , Elizabeth Bevilacqua
    • , Dieter B. Wildenauer
    • , Silvana Penco
    • , Larry J. Seidman
    • , Assen V. Jablensky
    • , Michael Davidson
    • , Pablo V. Gejman
    • , Alexander L. Richards
    • , Robert H. Brown
    • , Zita Ausrele Kucinskiene
    • , Jacques Mallet
    • , Aiden Corvin
    • , Anders D. Børglum
    • , Kimberley D. Chambert
    • , Jacqueline I. Goldstein
    • , Annelie Nordin
    • , James T. R. Walters
    • , Deborah A. Nertney
    • , Erik Söderman
    • , Randy L. Buckner
    • , Nigel M. Williams
    • , Farooq Amin
    • , Joseph D. Buxbaum
    • , Fritz Zimprich
    • , Aarno Palotie
    • , Christian Lunetta
    • , Douglas H. R. Blackwood
    • , Eric F. C. Cheung
    • , Eadbhard O’Callaghan
    • , Miaoxin Li
    • , Per Hoffmann
    • , Richard E. Straub
    • , Kai-How Farh
    • , Martilias S. Farrell
    • , Donald W. Black
    • , Margot Albus
    • , Siow Ann Chong
    • , Bela Melegh
    • , Brion S. Maher
    • , Paul Cormican
    • , Andrew McQuillin
    • , Esben Agerbo
    • , Carmel M. Loughland
    • , Chiara Zecca
    • , Stacy Steinberg
    • , Svetlana Limborska
    • , Patrick Vourc'h
    • , Andrew M. McIntosh
    • , Robert Freedman
    • , Sophie E. Legge
    • , Mark J. Daly
    • , Mark Weiser
    • , Srihari Gopal
    • , Laura Nisenbaum
    • , Gary Donohoe
    • , Douglas M. Ruderfer
    • , Joseph I. Friedman
    • , Elena Parkhomenko
    • , Alkes Price
    • , Noa Carrera
    • , Henrik B. Rasmussen
    • , Raquelle I. Mesholam-Gately
    • , Janis Klovins
    • , Schizophrenia Working Group of the Psychiatric Genomics Consortium
    • , Tune H. Pers
    • , Mari Nelis
    • , Marion Friedl
    • , Draga Toncheva
    • , Matthew C. Keller
    • , Sarah Tosato
    • , Kieran C. Murphy
    • , Sang-Yun Oh
    • , Hana Kuzelova-Ptackova
    • , David St Clair
    • , Shaun M. Purcell
    • , David A. Collier
    • , Josef Frank
    • , Cinzia Gellera
    • , Robin M. Murray
    • , Patricia T. Michie
    • , Andres Metspalu
    • , Cristina Moglia
    • , Inge Joa
    • , Peter M. Andersen
    • , Andrey Khrunin
    • , R Jeroen Pasterkamp
    • , Vihra Milanova
    • , Hualin Simon Xi
    • , Jo Knight
    • , Dai Wang
    • , Gerome Breen
    • , Elisabeth Stogmann
    • , Derek W. Morris
    • , Christos Pantelis
    • , Jeremy M. Silverman
    • , Jens R. Wendland
    • , Christian R. Schubert
    • , Martin Begemann
    •  & Jonathan Glass

News and Comment