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Amoeboid migration is a mode of rapid motility that is driven by actin-rich pseudopods, hydrostatically-generated blebs and a highly-contractile uropod, and is characterized by weak or absent adhesion to the substratum and little or no extracellular matrix proteolysis. The Dictyostelium amoeba, and lymphocytes, leukocytes, dendritic and cancer cells exhibit amoeboid motility.
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