Amoeboid migration articles from across Nature Portfolio

Latest Research and Reviews

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  YAP silencing by RB1 mutation is essential for small-cell lung cancer metastasis

  Small cell lung cancers (SCLC) have often inactivating mutations in RB1. In this study, the authors demonstrate that RB1 loss mediates low expression of YAP1 in SCLC tumors ultimately promoting metastasis and they propose to use benzamide family HDAC inhibitors to induce YAP1 expression for prevention of metastases.

  • Zhengming Wu
  • Junhui Su
  • Kun-Liang Guan

  ResearchOpen Access22 Sept 2023 Nature Communications

  Volume: 14, P: 5916
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  Whole-genome screens reveal regulators of differentiation state and context-dependent migration in human neutrophils

  Neutrophils provide a critical early defense as part of our innate immune system. Here, authors performed a genome-wide assessment of the molecular factors critical to proliferation, differentiation, and cell migration in a neutrophil-like cell.

  • Nathan M. Belliveau
  • Matthew J. Footer
  • Julie A. Theriot

  ResearchOpen Access18 Sept 2023 Nature Communications

  Volume: 14, P: 5770
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  AMPK is a mechano-metabolic sensor linking cell adhesion and mitochondrial dynamics to Myosin-dependent cell migration

  Cell metabolism must adapt to the energy needs of migrating cells. This study finds that fast amoeboid migrating cells harbor high AMPK activity, which controls both mitochondrial dynamics and cytoskeletal remodeling, enabling reduced energy needs.

  • Eva Crosas-Molist
  • Vittoria Graziani
  • Victoria Sanz-Moreno

  ResearchOpen Access22 May 2023 Nature Communications

  Volume: 14, P: 2740
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  The lysosomal Ragulator complex plays an essential role in leukocyte trafficking by activating myosin II

  Myosin II–mediated contractility is required for leukocyte migration. Here, authors show that lysosomes are involved in leukocyte migration by providing the platform where Ragulator complex interacts with the myosin phosphatase Rho-interacting protein (MPRIP) independently of mTORC1 and interferes with the interaction between MPRIP and a subunit of myosin light chain phosphatase (MLCP).

  • Takeshi Nakatani
  • Kohei Tsujimoto
  • Atsushi Kumanogoh

  ResearchOpen Access07 Jun 2021 Nature Communications

  Volume: 12, P: 3333
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  STIM-Orai1 signaling regulates fluidity of cytoplasm during membrane blebbing

  The cytoplasm in mammalian cells is considered homogeneous. Here authors report that the cytoplasmic fluidity is regulated in the blebbing cells, which is regulated by calcium concentration in the expanding blebs and involves the STIM-Orai1 pathway.

  • Kana Aoki
  • Shota Harada
  • Junichi Ikenouchi

  ResearchOpen Access20 Jan 2021 Nature Communications

  Volume: 12, P: 480
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  Substrate and cell fusion influence on slime mold network dynamics

  • Fernando Patino-Ramirez
  • Chloé Arson
  • Audrey Dussutour

  ResearchOpen Access15 Jan 2021 Scientific Reports

  Volume: 11, P: 1498