Alzheimer's disease

Alzheimer's disease is a progressive neurodegenerative disease that impairs memory and cognitive judgment and is often accompanied by mood swings, disorientation and eventually delirium. It is the most common cause of dementia.

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  • Research | | open

    • Yogatheesan Varatharajah
    • , Vijay K. Ramanan
    • , Ravishankar Iyer
    • , Prashanthi Vemuri
    • , Michael W. Weiner
    • , Paul Aisen
    • , Ronald Petersen
    • , Clifford R. Jack
    • , Andrew J. Saykin
    • , William Jagust
    • , John Q. Trojanowki
    • , Arthur W. Toga
    • , Laurel Beckett
    • , Robert C. Green
    • , John Morris
    • , Leslie M. Shaw
    • , Zaven Khachaturian
    • , Greg Sorensen
    • , Maria Carrillo
    • , Lew Kuller
    • , Marc Raichle
    • , Steven Paul
    • , Peter Davies
    • , Howard Fillit
    • , Franz Hefti
    • , David Holtzman
    • , M. Marcel Mesulam
    • , William Potter
    • , Peter Snyder
    • , Adam Schwartz
    • , Tom Montine
    • , Ronald G. Thomas
    • , Michael Donohue
    • , Sarah Walter
    • , Devon Gessert
    • , Tamie Sather
    • , Gus Jiminez
    • , Archana B. Balasubramanian
    • , Jennifer Mason
    • , Iris Sim
    • , Danielle Harvey
    • , Matthew Bernstein
    • , Nick Fox
    • , Paul Thompson
    • , Norbert Schuff
    • , Charles DeCArli
    • , Bret Borowski
    • , Jeff Gunter
    • , Matt Senjem
    • , David Jones
    • , Kejal Kantarci
    • , Chad Ward
    • , Robert A. Koeppe
    • , Norm Foster
    • , Eric M. Reiman
    • , Kewei Chen
    • , Chet Mathis
    • , Susan Landau
    • , Nigel J. Cairns
    • , Erin Franklin
    • , Lisa Taylor-Reinwald
    • , Virginia Lee
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    • , Michal Figurski
    • , Karen Crawford
    • , Scott Neu
    • , Tatiana M. Foroud
    • , Steven Potkin
    • , Kelley Faber
    • , Sungeun Kim
    • , Kwangsik Nho
    • , Leon Thal
    • , Neil Buckholtz
    • , Marilyn Albert
    • , Richard Frank
    • , John Hsiao
    • , Jeffrey Kaye
    • , Joseph Quinn
    • , Lisa Silbert
    • , Betty Lind
    • , Raina Carter
    • , Sara Dolen
    • , Lon S. Schneider
    • , Sonia Pawluczyk
    • , Mauricio Beccera
    • , Liberty Teodoro
    • , Bryan M. Spann
    • , James Brewer
    • , Helen Vanderswag
    • , Adam Fleisher
    • , Judith L. Heidebrink
    • , Joanne L. Lord
    • , Sara S. Mason
    • , Colleen S. Albers
    • , David Knopman
    • , Kris Johnson
    • , Rachelle S. Doody
    • , Javier Villanueva-Meyer
    • , Valory Pavlik
    • , Victoria Shibley
    • , Munir Chowdhury
    • , Susan Rountree
    • , Mimi Dang
    • , Yaakov Stern
    • , Lawrence S. Honig
    • , Karen L. Bell
    • , Beau Ances
    • , Maria Carroll
    • , Mary L. Creech
    • , Erin Franklin
    • , Mark A. Mintun
    • , Stacy Schneider
    • , Angela Oliver
    • , Daniel Marson
    • , David Geldmacher
    • , Marissa Natelson Love
    • , Randall Griffith
    • , David Clark
    • , John Brockington
    • , Erik Roberson
    • , Hillel Grossman
    • , Effie Mitsis
    • , Raj C. Shah
    • , Leyla deToledo-Morrell
    • , Ranjan Duara
    • , Maria T. Greig-Custo
    • , Warren Barker
    • , Chiadi Onyike
    • , Daniel D’Agostino
    • , Stephanie Kielb
    • , Martin Sadowski
    • , Mohammed O. Sheikh
    • , Anaztasia Ulysse
    • , Mrunalini Gaikwad
    • , P. Murali Doraiswamy
    • , Jeffrey R. Petrella
    • , Salvador Borges-Neto
    • , Terence Z. Wong
    • , Edward Coleman
    • , Steven E. Arnold
    • , Jason H. Karlawish
    • , David A. Wolk
    • , Christopher M. Clark
    • , Charles D. Smith
    • , Greg Jicha
    • , Peter Hardy
    • , Partha Sinha
    • , Elizabeth Oates
    • , Gary Conrad
    • , Oscar L. Lopez
    • , Mary Ann Oakley
    • , Donna M. Simpson
    • , Anton P. Porsteinsson
    • , Bonnie S. Goldstein
    • , Kim Martin
    • , Kelly M. Makino
    • , M. Saleem Ismail
    • , Connie Brand
    • , Adrian Preda
    • , Dana Nguyen
    • , Kyle Womack
    • , Dana Mathews
    • , Mary Quiceno
    • , Allan I. Levey
    • , James J. Lah
    • , Janet S. Cellar
    • , Jeffrey M. Burns
    • , Russell H. Swerdlow
    • , William M. Brooks
    • , Liana Apostolova
    • , Kathleen Tingus
    • , Ellen Woo
    • , Daniel H. S. Silverman
    • , Po H. Lu
    • , George Bartzokis
    • , Neill R Graff-Radford
    • , Francine Parfitt
    • , Kim Poki-Walker
    • , Martin R. Farlow
    • , Ann Marie Hake
    • , Brandy R. Matthews
    • , Jared R. Brosch
    • , Scott Herring
    • , Christopher H. van Dyck
    • , Richard E. Carson
    • , Martha G. MacAvoy
    • , Pradeep Varma
    • , Howard Chertkow
    • , Howard Bergman
    • , Chris Hosein
    • , Sandra Black
    • , Bojana Stefanovic
    • , Curtis Caldwell
    • , Ging-Yuek Robin Hsiung
    • , Benita Mudge
    • , Vesna Sossi
    • , Howard Feldman
    • , Michele Assaly
    • , Elizabeth Finger
    • , Stephen Pasternack
    • , Irina Rachisky
    • , John Rogers
    • , Dick Trost
    • , Andrew Kertesz
    • , Charles Bernick
    • , Donna Munic
    • , Emily Rogalski
    • , Kristine Lipowski
    • , Sandra Weintraub
    • , Borna Bonakdarpour
    • , Diana Kerwin
    • , Chuang-Kuo Wu
    • , Nancy Johnson
    • , Carl Sadowsky
    • , Teresa Villena
    • , Raymond Scott Turner
    • , Kathleen Johnson
    • , Brigid Reynolds
    • , Reisa A. Sperling
    • , Keith A. Johnson
    • , Gad Marshall
    • , Jerome Yesavage
    • , Joy L. Taylor
    • , Barton Lane
    • , Allyson Rosen
    • , Jared Tinklenberg
    • , Marwan N. Sabbagh
    • , Christine M. Belden
    • , Sandra A. Jacobson
    • , Sherye A. Sirrel
    • , Neil Kowall
    • , Ronald Killiany
    • , Andrew E. Budson
    • , Alexander Norbash
    • , Patricia Lynn Johnson
    • , Thomas O. Obisesan
    • , Saba Wolday
    • , Joanne Allard
    • , Alan Lerner
    • , Paula Ogrocki
    • , Curtis Tatsuoka
    • , Parianne Fatica
    • , Evan Fletcher
    • , Pauline Maillard
    • , John Olichney
    • , Charles DeCarli
    • , Owen Carmichael
    • , Smita Kittur
    • , Michael Borrie
    • , T.-Y. Lee
    • , Rob Bartha
    • , Sterling Johnson
    • , Sanjay Asthana
    • , Cynthia M. Carlsson
    • , Pierre Tariot
    • , Anna Burke
    • , Ann Marie Milliken
    • , Nadira Trncic
    • , Adam Fleisher
    • , Stephanie Reeder
    • , Vernice Bates
    • , Horacio Capote
    • , Michelle Rainka
    • , Douglas W. Scharre
    • , Maria Kataki
    • , Brendan Kelly
    • , Earl A. Zimmerman
    • , Dzintra Celmins
    • , Alice D. Brown
    • , Godfrey D. Pearlson
    • , Karen Blank
    • , Karen Anderson
    • , Laura A. Flashman
    • , Marc Seltzer
    • , Mary L. Hynes
    • , Robert B. Santulli
    • , Kaycee M. Sink
    • , Leslie Gordineer
    • , Jeff D. Williamson
    • , Pradeep Garg
    • , Franklin Watkins
    • , Brian R. Ott
    • , Geoffrey Tremont
    • , Lori A. Daiello
    • , Stephen Salloway
    • , Paul Malloy
    • , Stephen Correia
    • , Howard J. Rosen
    • , Bruce L. Miller
    • , David Perry
    • , Jacobo Mintzer
    • , Kenneth Spicer
    • , David Bachman
    • , Nunzio Pomara
    • , Raymundo Hernando
    • , Antero Sarrael
    • , Susan K. Schultz
    • , Karen Ekstam Smith
    • , Hristina Koleva
    • , Ki Won Nam
    • , Hyungsub Shim
    • , Norman Relkin
    • , Gloria Chaing
    • , Michael Lin
    • , Lisa Ravdin
    • , Amanda Smith
    • , Balebail Ashok Raj
    •  & Kristin Fargher
  • Research |

    The authors report that mitophagy is impaired in Alzheimer’s disease. Stimulation of mitophagy reverses cognitive deficits in nematode and mouse models of Alzheimer’s disease, suggesting a potential therapeutic intervention.

    • Evandro F. Fang
    • , Yujun Hou
    • , Konstantinos Palikaras
    • , Bryan A. Adriaanse
    • , Jesse S. Kerr
    • , Beimeng Yang
    • , Sofie Lautrup
    • , Md Mahdi Hasan-Olive
    • , Domenica Caponio
    • , Xiuli Dan
    • , Paula Rocktäschel
    • , Deborah L. Croteau
    • , Mansour Akbari
    • , Nigel H. Greig
    • , Tormod Fladby
    • , Hilde Nilsen
    • , M. Zameel Cader
    • , Mark P. Mattson
    • , Nektarios Tavernarakis
    •  & Vilhelm A. Bohr
  • Reviews |

    Brain inclusions of the microtubule-associated protein tau are prominent pathological features in a spectrum of neurodegenerative diseases. MAPT gene mutations that encodes tau can directly cause neurodegeneration. Herein, the authors review what is known about MAPT mutations dysfunctions with a focus on the prion-like properties of tau protein.

    • Kevin H. Strang
    • , Todd E. Golde
    •  & Benoit I. Giasson
  • Research |

    The authors found that white blood cells plug about 2% of capillaries in the brains of Alzheimer’s disease mouse models. When the adhesion of these cells was blocked, cerebral blood flow immediately increased and cognitive performance rapidly improved.

    • Jean C. Cruz Hernández
    • , Oliver Bracko
    • , Calvin J. Kersbergen
    • , Victorine Muse
    • , Mohammad Haft-Javaherian
    • , Maxime Berg
    • , Laibaik Park
    • , Lindsay K. Vinarcsik
    • , Iryna Ivasyk
    • , Daniel A. Rivera
    • , Yiming Kang
    • , Marta Cortes-Canteli
    • , Myriam Peyrounette
    • , Vincent Doyeux
    • , Amy Smith
    • , Joan Zhou
    • , Gabriel Otte
    • , Jeffrey D. Beverly
    • , Elizabeth Davenport
    • , Yohan Davit
    • , Charles P. Lin
    • , Sidney Strickland
    • , Costantino Iadecola
    • , Sylvie Lorthois
    • , Nozomi Nishimura
    •  & Chris B. Schaffer

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