Allotransplantation articles from across Nature Portfolio

The FDA-approved drug disulfiram can inhibit B cells and infiltration of macrophages in a mouse model of heart transplantation.

Viral infection is a common risk for immune-compromised individuals, particularly pediatric patients receiving hematopoietic stem cell transplants. Here the authors report a phase II trial testing adoptive transfer of third party, virus-specific T cells on the feasibility, safety, clinical responses, as well as homeostasis of antiviral immunity in the recipients.

In graft rejection, Th17 promotes tertiary lymphoid tissue, neutrophilic infiltration and DSAs. The RORγt inverse agonist TF-S14 inhibits Th17 cytokines, antibody class switching and prolongs allograft survival in sensitized mice.