Allergy is an inappropriate immune response to otherwise harmless antigens. Allergy requires initial sensitization with a specific antigen. The subsequent exposure to the same antigen can then result in pathologic reactions mediated by immunoglobulin E (IgE), mast cells and basophils.

Latest Research and Reviews

News and Comment

  • Research Highlights |

    A new study describes how mechanical skin injury caused by scratching can promote food anaphylaxis by increasing the number of mast cells in the gut through a keratinocyte–ILC2–tuft cell pathway.

    • Kirsty Minton
  • News and Views |

    An assessment of the taxonomic composition of airborne pollen using targeted high-throughput sequencing may help in understanding environmental and human drivers of the grass pollen season and in allergy prevention and management.

    • Annette Menzel
  • News and Views |

    A new study provides evidence that colonization of germ-free mice with faecal bacteria from healthy infants can protect against signs of cow’s milk allergy in mice. The results from this and other studies raise the intriguing question of whether the gut microbiota can be manipulated for food allergy prevention and therapy.

    • Supinda Bunyavanich
  • News and Views |

    Group 2 innate lymphoid cells (ILC2s) that produce the cytokine IL-5 are found in lung, gut, fat and skin tissues. New findings indicate that ILC2s in different tissues selectively express distinct functional cytokine receptors for cell activation in response to the local environment.

    • Jinfang Zhu
    Nature Immunology 19, 1042-1044