Ageing

Ageing is the process during which structural and functional changes accumulate in an organism as a result of the passage of time. The changes manifest as a decline from the organism’s peak fertility and physiological functions until death.

Latest Research and Reviews

  • Reviews |

    Senescence is a state of permanent cell cycle arrest. This Review highlights the chemical characteristics of senescence and how we can use small molecules to target, detect or eliminate senescent cells, as well as to induce or inhibit senescence.

    • Beatriz Lozano-Torres
    • , Alejandra Estepa-Fernández
    • , Miguel Rovira
    • , Mar Orzáez
    • , Manuel Serrano
    • , Ramón Martínez-Máñez
    •  & Félix Sancenón
  • Research | | open

    Microbiota impacts all major aspects of physiology, but little is known about its effects on age-related changes in immune responses. Here the authors show that gut microbiota transfer between adult and old mice increases local but not systemic germinal centre responses regardless of age directionality.

    • Marisa Stebegg
    • , Alyssa Silva-Cayetano
    • , Silvia Innocentin
    • , Timothy P. Jenkins
    • , Cinzia Cantacessi
    • , Colin Gilbert
    •  & Michelle A. Linterman
  • Research | | open

    Senescent cells increase with ageing and may cause inflammatory conditions, but how this accumulation is mediated is still unclear. Here the authors show that senescent cells express HLA-E to suppress NKG2A-mediated natural killer and CD8 T cell activation to avoid targeted elimination, while blocking NKG2A helps promote immunity against senescent cells.

    • Branca I. Pereira
    • , Oliver P. Devine
    • , Milica Vukmanovic-Stejic
    • , Emma S. Chambers
    • , Priya Subramanian
    • , Neil Patel
    • , Alex Virasami
    • , Neil J. Sebire
    • , Veronica Kinsler
    • , Alexis Valdovinos
    • , Claude Jourdan LeSaux
    • , João F. Passos
    • , Antony Antoniou
    • , Malcom H. A. Rustin
    • , Judith Campisi
    •  & Arne N. Akbar
  • Reviews |

    Male hypogonadism is a disorder associated with low testosterone levels and impaired spermatogenesis. The condition can arise from inherent defects in the testes or abnormalities in the regulation of testosterone secretion at the hypothalamic or pituitary level. This Primer summarizes the conditions that can lead to hypogonadism in boys and men.

    • Andrea Salonia
    • , Giulia Rastrelli
    • , Geoffrey Hackett
    • , Stephanie B. Seminara
    • , Ilpo T. Huhtaniemi
    • , Rodolfo A. Rey
    • , Wayne J. G. Hellstrom
    • , Mark R. Palmert
    • , Giovanni Corona
    • , Gert R. Dohle
    • , Mohit Khera
    • , Yee-Ming Chan
    •  & Mario Maggi

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