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Adult stem cells are cells in the adult that can both self-renew by dividing and give rise to more specialised cell types present in the tissue in which they reside. They serve to maintain and repair the tissue.
Cruz-Acuña et al. develop synthetic hydrogels that support the generation and expansion of viable human intestinal organoids from pluripotent stem cells and can be used as injectable vehicles for organoid engraftment and wound healing.
After acute inflammation, epithelial stem cells retain a memory that accelerates restoration of the skin barrier during subsequent tissue damage, and this enhancement is dependent on the AIM2 inflammasome and its downstream effectors.
Upon injury of the developing mouse cerebellum, endogenous repair mechanisms can heal the brain and prevent behavioral motor deficits. At the right time, with the right cues, the brain can repair itself.
Zika virus infection is associated with birth defects, including microcephaly, but also with disorders of peripheral nerves. Oh et al. use rodent and human cell models to explore how the virus affects the peripheral nervous system.