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Addiction involves loss of control over use of a substance, often in the presence of physiological and psychological dependence on a substance and compulsion to continue seeking and using the substance despite possible negative consequences.
In 653,790 individuals, this multi-ancestral meta-analysis of tobacco use disorder finds 461 potential risk genes and hundreds of associations with health outcomes, showcasing the utility of electronic health records for genetic research.
A patient-centred system that leverages the analysis of sweat via wearable sensors may better support the management of patients with substance-use disorders.
Nicotine withdrawal and anxiety symptoms are overlapping barriers to smoking cessation. We examined the effects of a smoking cessation treatment — noninvasive neuromodulation — on nicotine withdrawal and anxiety symptoms, which revealed information on how neuromodulation can treat substance use disorders.
Increasing levels of glial-derived neurotrophic factor using a gene-therapy approach in a macaque model of alcohol use disorder resulted in a lower tendency to relapse into alcohol consumption after a period of abstinence.
