Adaptive immunity

Adaptive immunity is the protection of a host organism from a pathogen or toxin. It is mediated by B cells and T cells, and is characterized by immunological memory. Adaptive immunity is highly specific to a given antigen and is highly adaptable.

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Latest Research and Reviews

  • Research | | open

    The JAK-STAT signaling pathway is important for cytokine responses and CD4 T-cell differentiation. Here the authors show that Stat1 also serves to protect CD4 T cells from natural killer cell-mediated killing, potentially by promoting the expression of Nlrc5 and MHC-I, to preserve the induction of experimental colitis via the adoptive transfer of CD4 T cells.

    • Yu Hui Kang
    • , Amlan Biswas
    • , Michael Field
    •  & Scott B. Snapper
  • Research | | open

    Orthobunyaviruses (OBVs) cause severe disease in humans and farm animals, but the molecular basis for infection is not fully understood. Here, the authors present crystal structures of free and antibody-bound OBV envelope glycoproteins and show that their domains enable efficient immunization in a mouse model.

    • Jan Hellert
    • , Andrea Aebischer
    • , Kerstin Wernike
    • , Ahmed Haouz
    • , Emiliana Brocchi
    • , Sven Reiche
    • , Pablo Guardado-Calvo
    • , Martin Beer
    •  & Félix A. Rey
  • Research | | open

    Autoreactive T cells are suspected to destroy hypocretin-producing neurons in narcolepsy. Here the authors detect CD8 T cells recognizing narcolepsy-related proteins in healthy individuals and in patients with narcolepsy, and show that the frequency of self-reactive CD8 T cells differs between patients and controls sharing the same HLA-II risk allele.

    • Natasja Wulff Pedersen
    • , Anja Holm
    • , Nikolaj Pagh Kristensen
    • , Anne-Mette Bjerregaard
    • , Amalie Kai Bentzen
    • , Andrea Marion Marquard
    • , Tripti Tamhane
    • , Kristoffer Sølvsten Burgdorf
    • , Henrik Ullum
    • , Poul Jennum
    • , Stine Knudsen
    • , Sine Reker Hadrup
    •  & Birgitte Rahbek Kornum
  • Research |

    Stemness is crucial for the maintenance of long-term T cell memory. Gattinoni and colleagues demonstrate that the transcription factor c-Myb is essential for the establishment of a stemness program in the CD8+ T cell memory compartment.

    • Sanjivan Gautam
    • , Jessica Fioravanti
    • , Wei Zhu
    • , John B. Le Gall
    • , Philip Brohawn
    • , Neal E. Lacey
    • , Jinhui Hu
    • , James D. Hocker
    • , Nga Voong Hawk
    • , Veena Kapoor
    • , William G. Telford
    • , Devikala Gurusamy
    • , Zhiya Yu
    • , Avinash Bhandoola
    • , Hai-Hui Xue
    • , Rahul Roychoudhuri
    • , Brandon W. Higgs
    • , Nicholas P. Restifo
    • , Timothy P. Bender
    • , Yun Ji
    •  & Luca Gattinoni
    Nature Immunology 20, 337-349
  • Reviews |

    Double-strand breaks in DNA generated during the normal assembly and diversification of lymphocyte antigen receptor genes or by genotoxic agents during infection activate DNA damage responses. Besides repairing damaged DNA, these responses trigger important signalling events that regulate immune cell development and function.

    • Jeffrey J. Bednarski
    •  & Barry P. Sleckman

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