Adaptive immunity

Adaptive immunity is the protection of a host organism from a pathogen or toxin. It is mediated by B cells and T cells, and is characterized by immunological memory. Adaptive immunity is highly specific to a given antigen and is highly adaptable.

Latest Research and Reviews

  • Research |

    Bacteriotherapy using gut-derived bacteria from healthy human infants, but not infants with food allergies, suppresses food allergy symptoms in mice via induction of Foxp3 + Rorγt + regulatory T cells

    • Azza Abdel-Gadir
    • , Emmanuel Stephen-Victor
    • , Georg K. Gerber
    • , Magali Noval Rivas
    • , Sen Wang
    • , Hani Harb
    • , Leighanne Wang
    • , Ning Li
    • , Elena Crestani
    • , Sara Spielman
    • , William Secor
    • , Heather Biehl
    • , Nicholas Dibendetto
    • , Xiaoxi Dong
    • , Dale T. Umetsu
    • , Lynn Bry
    • , Rima Rachid
    •  & Talal A. Chatila
  • Research |

    IFN-λ has important innate immune system functions at mucosal surfaces, but its importance in adaptive immunity is largely unknown. Using an influenza infection model, Gale and colleagues demonstrate that IFN-λ is essential for effective adaptive cellular immunity in the lung.

    • Emily A. Hemann
    • , Richard Green
    • , J. Bryan Turnbull
    • , Ryan A. Langlois
    • , Ram Savan
    •  & Michael Gale Jr
  • Research |

    Genetic, pharmacological and metabolomics experiments reveal that the malate–aspartate shuttle and mitochondrial citrate export support the differentiation of mouse T helper 1 cells, whereas succinate dehydrogenase enforces their terminal effector function.

    • Will Bailis
    • , Justin A. Shyer
    • , Jun Zhao
    • , Juan Carlos Garcia Canaveras
    • , Fatimah J. Al Khazal
    • , Rihao Qu
    • , Holly R. Steach
    • , Piotr Bielecki
    • , Omair Khan
    • , Ruaidhri Jackson
    • , Yuval Kluger
    • , Louis J. Maher III
    • , Joshua Rabinowitz
    • , Joe Craft
    •  & Richard A. Flavell
    Nature, 1-5
  • Research |

    Long-lived, self-renewing ‘progenitor-like’ CD8+ T cells can arise during chronic viral infection or in cancer. Wu and colleagues identify the transcription factor TOX as essential to endow ‘stemness’ and long-term persistence in the face of chronic infection.

    • Chen Yao
    • , Hong-Wei Sun
    • , Neal E. Lacey
    • , Yun Ji
    • , E. Ashley Moseman
    • , Han-Yu Shih
    • , Elisabeth F. Heuston
    • , Martha Kirby
    • , Stacie Anderson
    • , Jun Cheng
    • , Omar Khan
    • , Robin Handon
    • , Julie Reilley
    • , Jessica Fioravanti
    • , Jinhui Hu
    • , Selamawit Gossa
    • , E. John Wherry
    • , Luca Gattinoni
    • , Dorian B. McGavern
    • , John J. O’Shea
    • , Pamela L. Schwartzberg
    •  & Tuoqi Wu
    Nature Immunology 20, 890-901

News and Comment