About Michael Teitell

Michael Teitell studies the mitochondrial function and genetic variation of pluripotent stem cells at the Broad Stem Cell Research Center of the University of California, Los Angeles. His lab works to understand stem cell processes, such as metabolism control and self-renewal, to determine whether and how these processes are usurped during malignant transformation.

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• Michael Teitell: How to assess a stem cell genome

Featured expert's recommendations

• Characterization of human embryonic stem cell lines by the International Stem Cell Initiative
  This paper describes an international consortium's initial characterization of 75 human embryonic stem cell (hES cell) lines and establishes each line's unique identity.
  Adewumi, O., et al. Nature Biotechnol. 25, 803-816 (2007).

• Adaptation to culture of human embryonic stem cells and oncogenesis in vivo
  Andrews and colleagues describe hES cell line genome instability caused by culture adaptation over time, with many changes similar to those seen in human tumours - especially testicular germ cell cancers.
  Baker , D.E., et al. Nature Biotechnol. 25, 207-215 (2007).

• Copy number variant analysis of human embryonic stem cells
  This paper examines copy number differences between two hES cell lines that differ in their neurogenic potential as one putative source for varying functional and differentiation outcomes.
  Wu, H. et al. Stem Cells 26, 1484-1489 (2008).

• Marked differences in differentiation propensity among human embryonic stem cell lines
  Melton and colleagues describe variations in the differentiation potential of 17 hES cell lines that could arise from genome differences in outbred human populations as well as from varying epigenetic states.
  Osafune, K. et al. Nature Biotechnol. 26, 313-315 (2008).

• Global variation in copy number in the human genome
  One of several articles exploring the extent and variability of copy number variation in somatic cells from human subpopulations, which by extension suggests the amount of genome complexity between hES cell lines from unrelated donors.
  Redon, R. et al. Nature 444, 444-454 (2006).

• Genomics: Massively parallel sequencing
  This brief commentary by Rogers and Venter introduced massively parallel sequencing as a viable approach for determining genome-wide genetic heterogeneity.
  Rogers, Y. H. & Venter, J. C. Nature 437, 326-327 (2005).

• TORC2 regulates germinal center repression of the TCL1 oncoprotein to promote B cell development and inhibit transformation
  This paper describes a previously unknown mechanism for regulating TCL1, a lymphocyte oncogene that regulates mouse ES cell self-renewal, and provides a potential connection between malignant transformation and mechanisms of pluripotent stem cell maintenance.
  Kuraishy, A. I. et al. Proc. Natl. Acad. Sci. USA 104, 10175-10180 (2007).