Showing 1–25 of 4528 results

  1. Research |

    • ...primary site of action for cocaine, and the dopamine system... ...mediate the reinforcing effects of cocaine, the dopaminergic variations underlying... individual differences in cocaine self-administration behaviors are not... ...economics approach with cocaine self-administration and...
  2. Research |

    • ...JJC8-016 dose-dependently inhibited cocaine-enhanced locomotion, cocaine self-administration, and cocaine-induced reinstatement of drug-seeking... ...behavior, whereas R-MOD inhibited cocaine-induced reinstatement only at the... ...DAT inhibitor that has no cocaine-like abuse potential by itself...
  3. Research | | Open

    • ...(NAc) in relapse to cocaine seeking. We found that... ...to drug-related cues reinstated cocaine-seeking behavior and increased AMPK... ...decreased cue-induced reinstatement of cocaine seeking and inhibited the mammalian... ...cue-induced reinstatement of cocaine seeking and enhanced mTORC1...
  4. Research |

    • ...nicotine addiction, but not for cocaine addiction. One of the... major obstacles is the cocaine-like addictive potential of the... ...have translational potential for treating cocaine addiction. In vitro ligand-... ...and a competitive inhibitor of cocaine binding to the DAT.... ..., cocaine self...
  5. Research |

  6. Research | | Open

    • ...first time we demonstrate that cocaine induces over expression of DC... ...in DCs. We found that cocaine activates a DC-SIGN mediated... ...studies of HIV-1 in cocaine treated DCs revealed increased co... ...degradation of HIV-1 in cocaine treated DCs. Furthermore, we... ...cocaine induced...
  7. Research | | Open

    • ...and females become addicted to cocaine, females transition to addiction... ...cycle-dependent mechanism controlling increased cocaine reward in females. During... ...to increase the ability of cocaine to inhibit its function,... ...mice conditioned to associate cocaine with contextual cues during...
  8. Research | | Open

  9. Research | | Open

    • Cocaine is a highly addictive narcotic... ...However, it remains elusive whether cocaine modifies spines in a cell... ...regulatory mechanism(s) involved in cocaine-induced modification of spine density... ...current study, we report that cocaine exposure differentially alters spine density...
  10. Research |

    • ...and behavioral changes driven by cocaine. We demonstrate that cadherin... ...synapses onto dopaminergic neurons following cocaine-mediated behavioral conditioning. Furthermore,... ...membrane of these synapses blocks cocaine-induced synaptic plasticity, leading... ...induced by cocaine. Our...
  11. Research |

    • ...risk of relapse in recovering cocaine addicts are not well understood... ..., via elevated corticosterone, potentiates cocaine-primed reinstatement of cocaine seeking following self-administration in... ...the hypothesis that corticosterone potentiates cocaine-primed reinstatement by blockade of...
  12. Research | | Open

    • ...ligand, activin A, in cocaine relapse is unknown. Activin... ..., and microglia) following a cocaine binge paradigm. Cocaine exposure significantly increased the levels... ...animals that had self-administered cocaine prior to the 14-day... ...target for the treatment of cocaine relapse.
  13. Research | | Open

    • Adolescent cocaine use increases the likelihood of... ...etiological factors may include a cocaine-induced bias towards so-called... ...habits. To determine whether adolescent cocaine exposure indeed impacts decision-making... ...mice to orally self-administer cocaine. In adulthood, males with...
  14. Research |

  15. Research |

    • ...-related and locomotor effects of cocaine, and reduce cocaine self-administration by rhesus monkeys... ...(i.v.)), with cocaine alone (0.2 mg/... ...v.), and with nalbuphine+cocaine in combination, under placebo-... ...DSM-IV) criteria for current cocaine abuse. Nalbuphine serum levels...
  16. Research |

    • Cocaine use disorder is a global... ...for mediating serotonergic attenuation of cocaine abuse-related neurochemical and behavioral... ...per day, intramuscular) attenuated cocaine reinforcement under a concurrent ‘... choice’ schedule of cocaine and food availability in rhesus... ...cocaine...
  17. Research |

    • ...drug-naive male offspring of cocaine-exposed sires have memory formation... ...Dao1) in the hippocampus of cocaine-sired male progeny. Increased... ...in the hippocampus of male cocaine-sired progeny, some of... ...results demonstrate that paternal cocaine exposure produces epigenetic remodeling...
  18. Reviews |

    • ...is challenging for individuals with cocaine addiction to achieve abstinence,... ...by cues associated with prior cocaine use. This vulnerability to... ...rodent studies of cue-induced cocaine craving during abstinence, with...
  19. Research | | Open

  20. Research |

    • ...VTA) Cav1.3 channels mediate cocaine-related and depressive-like behavior... ...-BayK-8644 (BayK) enhanced cocaine conditioned place preference and cocaine psychomotor activity while inducing depressive... ...the NAc shell reversed the cocaine and depressive-like phenotypes.... ...the cocaine-...
  21. Research |

    • ...influences the reinforcing effects of cocaine and the effects of some... drugs on cocaine self-administration. In this... ...on the reinforcing effects of cocaine using a food-drug choice... ...he was studied in a cocaine-food choice paradigm. For... ..., sensitivity to cocaine reinforcement was...
  22. Research |

    • ...rat alcohol exposure procedures and cocaine self-administration and reinstatement (... ...of rats for acquisition of cocaine self-administration using ascending cocaine doses (0.125, 0... ...–response curve after acquisition of cocaine self-administration. We then... ...induced by cocaine-...cocaine
  23. Research |

    • ...Drug Administration-approved pharmacotherapy for cocaine addiction. Monoamine releasers such... ...of chronic PDM to reduce cocaine self-administration by rhesus monkeys... ...featured both daily assessments of cocaine vs food choice (to... ...behavior away from cocaine choice and toward...
  24. Research |

    • ...two prominent strategies for treating cocaine dependence. This study investigated... ...in a preclinical model of cocaine vs food choice. Six... ...(FR) 100 schedule) and cocaine injections (0–0.1 ... ...the FR response requirement for cocaine or food was varied (... food, FR 100; cocaine, FR 1–100;
  25. Research |

    • Cocaine abuse and dependence is a... ...studies, acute buspirone treatment reduced cocaine self-administration at doses that... ...treatment on self-administration of cocaine and food. Five adult... ...were trained to self-administer cocaine and food during four 1... ...by cocaine, and... ...cocaine...