Showing 1–25 of 4606 results

  1. Research |

    • ...to early withdrawal from repeated cocaine administration, de novo dendritic... ...facilitates the rewarding properties of cocaine. Early withdrawal from repeated cocaine also produces dramatic alterations in... ...but how such alterations influence cocaine’s effects on dendritic spine...
  2. Research |

    • ...dorsal striatum (DS) of cocaine-conditioned mice. Cocaine significantly decreased SAM/SAH ratio... ...dorsomedial striatum (DMS) attenuated cocaine conditioned place preference (CPP)... ...-DMS infusion of MeN attenuated cocaine CPP and the activities of... ...showed that cocaine increased...cocaine
  3. Research | | Open

    • ...were injected with saline or cocaine (a single injection per... ...screen chamber while they were cocaine challenged. All rats significantly... ...exposed to and challenged with cocaine, except those in the... ...quality of decision-making, and cocaine may help to aggravate this...
  4. Research |

    • ...neuroadaptations in reward circuits following cocaine self-administration (SA) underlie... ...PrL cortex following a final cocaine SA session results in attenuation... of reinstatement of cocaine-seeking. Inhibiting BDNF’s... ...the end of the last cocaine SA session, would block... ...cocaine-...
  5. Research | | Open

    • ...acupoint suppressed psychomotor response to cocaine, which was abolished by... ...effects of peripheral stimulation on cocaine-induced neuronal activation in the... ...reversed the inhibitory effects on cocaine locomotion produced by peripheral stimulation... ...psychomotor response to cocaine...
  6. Research | | Open

    • ...their incentive motivation to seek cocaine. We find that the... ...of high incentive response to cocaine is contingent on high motivation... ...it is elicited by voluntary cocaine administration, but not high... intake of cocaine itself. We also find...
  7. Research |

    • ...primary site of action for cocaine, and the dopamine system... ...mediate the reinforcing effects of cocaine, the dopaminergic variations underlying... individual differences in cocaine self-administration behaviors are not... ...economics approach with cocaine self-administration and...
  8. Research | | Open

    • ...DAT) is the target of cocaine and HIV-1 transactivator of... ...molecules with potential attenuation of cocaine and Tat binding to DAT... ...-20041 and SRI-30827 on cocaine binding on wild type (... ...of [3H]DA uptake by cocaine in WT hDAT. The... ...SRI-30827 following cocaine slowed the...
  9. Research |

    • ...JJC8-016 dose-dependently inhibited cocaine-enhanced locomotion, cocaine self-administration, and cocaine-induced reinstatement of drug-seeking... ...behavior, whereas R-MOD inhibited cocaine-induced reinstatement only at the... ...DAT inhibitor that has no cocaine-like abuse potential by itself...
  10. Research | | Open

    • ...dlPFC neurons of humans with cocaine use disorder, we performed... ...from post-mortem dlPFC of cocaine addicts and healthy controls.... ...toward a transcriptional mechanism whereby cocaine alters specific gene networks in... ...dlPFC neurons associated with cocaine use disorder that contains...
  11. Research |

    • ...nicotine addiction, but not for cocaine addiction. One of the... major obstacles is the cocaine-like addictive potential of the... ...have translational potential for treating cocaine addiction. In vitro ligand-... ...and a competitive inhibitor of cocaine binding to the DAT.... ..., cocaine self...
  12. Research |

  13. Research |

    • ...rewarding and reinforcing effects of cocaine, but the underlying mechanisms... ...the PDE4 inhibitor rolipram attenuated cocaine-induced locomotor sensitization in mice... . Repeated cocaine exposure in vivo caused a... ...in midbrain slices ex vivo. Cocaine exposure disrupted the balance between...
  14. Research |

    • ...drug taking. Rats self-administered cocaine for 1 h daily over... ...lever pressing no longer produced cocaine. In experiment 1, quantitative... ...and corresponding receptors. Reinstatement of cocaine seeking was then tested after... ...In experiment 1, cocaine self-administration increased...
  15. Research | | Open

    • ...effects of the DAT inhibitor cocaine and its fluorescent analog JHC1... ...in turn favors binding of cocaine. Imaging analysis showed that... ...distributed within the plasma membrane. Cocaine binding significantly increased the density...
  16. Research |

  17. Research |

    • ...-related and locomotor effects of cocaine, and reduce cocaine self-administration by rhesus monkeys... ...(i.v.)), with cocaine alone (0.2 mg/... ...v.), and with nalbuphine+cocaine in combination, under placebo-... ...DSM-IV) criteria for current cocaine abuse. Nalbuphine serum levels...
  18. Research | | Open

    • Cocaine is a highly addictive narcotic... ...However, it remains elusive whether cocaine modifies spines in a cell... ...regulatory mechanism(s) involved in cocaine-induced modification of spine density... ...current study, we report that cocaine exposure differentially alters spine density...
  19. Research |

    • ...OXR antagonists to attenuate acute cocaine-evoked impulsivity. Finally, immunohistochemistry... ...) orexin receptor antagonist, reduced cocaine-evoked premature responses in 5... ...of VTA, but did attenuate cocaine- and orexin-induced increases...
  20. Research | | Open

    • Adolescent cocaine use increases the likelihood of... ...etiological factors may include a cocaine-induced bias towards so-called... ...habits. To determine whether adolescent cocaine exposure indeed impacts decision-making... ...mice to orally self-administer cocaine. In adulthood, males with...
  21. Research |

    • ...risk of relapse in recovering cocaine addicts are not well understood... ..., via elevated corticosterone, potentiates cocaine-primed reinstatement of cocaine seeking following self-administration in... ...the hypothesis that corticosterone potentiates cocaine-primed reinstatement by blockade of...
  22. Research | | Open

    • ...first time we demonstrate that cocaine induces over expression of DC... ...in DCs. We found that cocaine activates a DC-SIGN mediated... ...studies of HIV-1 in cocaine treated DCs revealed increased co... ...degradation of HIV-1 in cocaine treated DCs. Furthermore, we... ...cocaine induced...
  23. Research | | Open

    • ...and females become addicted to cocaine, females transition to addiction... ...cycle-dependent mechanism controlling increased cocaine reward in females. During... ...to increase the ability of cocaine to inhibit its function,... ...mice conditioned to associate cocaine with contextual cues during...
  24. Reviews |

    • ...is challenging for individuals with cocaine addiction to achieve abstinence,... ...by cues associated with prior cocaine use. This vulnerability to... ...rodent studies of cue-induced cocaine craving during abstinence, with...
  25. Research |

    • ...Drug Administration-approved pharmacotherapy for cocaine addiction. Monoamine releasers such... ...of chronic PDM to reduce cocaine self-administration by rhesus monkeys... ...featured both daily assessments of cocaine vs food choice (to... ...behavior away from cocaine choice and toward...