Showing 1–25 of 795 results
Research | | Open
Accumulation of differentiating intestinal stem cell progenies drives tumorigenesis
- Stem cell self-renewal and differentiation are... ...and prevent cancer. Mutations causing stem cell proliferation are traditionally the focus... ...the contribution of the differentiating stem cell progenies in tumorigenesis is poorly... ...enteroblast (EB), the intestinal stem cell
- Zongzhao Zhai
- , Shu Kondo
- , Nati Ha
- , Jean-Philippe Boquete
- , Michael Brunner
- , Ryu Ueda
- & Bruno Lemaitre
Research | | Open
Dipeptide species regulate p38MAPK–Smad3 signalling to maintain chronic myelogenous leukaemia stem cells
- ...chronic myelogenous leukaemia (CML) stem cell population could provide a target... ...signalling is regulated in CML stem cells. In this study, we... ...differences between murine normal haematopoietic stem cells (HSCs) and CML stem cells using metabolomics techniques. Strikingly,...
- Kazuhito Naka
- , Yoshie Jomen
- , Kaori Ishihara
- , Junil Kim
- , Takahiro Ishimoto
- , Eun-Jin Bae
- , Robert P. Mohney
- , Steven M. Stirdivant
- , Hiroko Oshima
- , Masanobu Oshima
- , Dong-Wook Kim
- , Hiromitsu Nakauchi
- , Yoshihiro Takihara
- , Yukio Kato
- , Akira Ooshima
- & Seong-Jin Kim
Research | | Open
The Notch and Wnt pathways regulate stemness and differentiation in human fallopian tube organoids
- ...of the presence of adult stem cells. We show that single... We show that single epithelial stem cells in vitro can give rise... Notch signalling causes downregulation of stem cell-associated genes in parallel with...
- Mirjana Kessler
- , Karen Hoffmann
- , Volker Brinkmann
- , Oliver Thieck
- , Susan Jackisch
- , Benjamin Toelle
- , Hilmar Berger
- , Hans-Joachim Mollenkopf
- , Mandy Mangler
- , Jalid Sehouli
- , Christina Fotopoulou
- & Thomas F. Meyer
Research | | Open
Sepsis induces long-term metabolic and mitochondrial muscle stem cell dysfunction amenable by mesenchymal stem cell therapy
- ...inefficient muscle regeneration. Engrafting mesenchymal stem cells improves the septic status by... ...that sepsis affects quiescent muscle stem cells and that mesenchymal stem cells might act as a preventive...
- P. Rocheteau
- , L. Chatre
- , D. Briand
- , M. Mebarki
- , G. Jouvion
- , J. Bardon
- , C. Crochemore
- , P. Serrani
- , P. P. Lecci
- , M. Latil
- , B. Matot
- , P. G. Carlier
- , N. Latronico
- , C. Huchet
- , A. Lafoux
- , T. Sharshar
- , M. Ricchetti
- & F. Chrétien
Research | | Open
SF3B1 mutant MDS-initiating cells may arise from the haematopoietic stem cell compartment
- ...of myelodysplastic syndrome (MDS) stem cells in 5q-MDS patients,... ...it is unclear whether haematopoietic stem cells (HSCs) could also be...
- Syed A. Mian
- , Kevin Rouault-Pierre
- , Alexander E. Smith
- , Thomas Seidl
- , Irene Pizzitola
- , Aytug Kizilors
- , Austin G. Kulasekararaj
- , Dominique Bonnet
- & Ghulam J. Mufti
Research | | Open
A basal-like breast cancer-specific role for SRF–IL6 in YAP-induced cancer stemness
- ...recruitment of YAP to mammary stem cell (MaSC) signature-gene promoters...
- Tackhoon Kim
- , Suk-Jin Yang
- , Daehee Hwang
- , Jinhoi Song
- , Minchul Kim
- , Sang Kyum Kim
- , Keunsoo Kang
- , Jaebum Ahn
- , Daeyoup Lee
- , Mi-young Kim
- , Seyun Kim
- , Ja Seung Koo
- , Sang Seok Koh
- , Seon-Young Kim
- & Dae-Sik Lim
Research | | Open
PTEN deficiency reprogrammes human neural stem cells towards a glioblastoma stem cell-like phenotype
- ...neoplastic transformation of human neural stem cells (NSCs), but not... ...(NSCs), but not mesenchymal stem cells. PTEN-deficient NSCs display... ...‘aggressiveness’ in human glioblastoma stem cells. In a large clinical...
- Shunlei Duan
- , Guohong Yuan
- , Xiaomeng Liu
- , Ruotong Ren
- , Jingyi Li
- , Weizhou Zhang
- , Jun Wu
- , Xiuling Xu
- , Lina Fu
- , Ying Li
- , Jiping Yang
- , Weiqi Zhang
- , Ruijun Bai
- , Fei Yi
- , Keiichiro Suzuki
- , Hua Gao
- , Concepcion Rodriguez Esteban
- , Chuanbao Zhang
- , Juan Carlos Izpisua Belmonte
- , Zhiguo Chen
- , Xiaomin Wang
- , Tao Jiang
- , Jing Qu
- , Fuchou Tang
- & Guang-Hui Liu
Research | | Open
TAK1 modulates satellite stem cell homeostasis and skeletal muscle repair
- Satellite cells are resident adult stem cells that are required for regeneration... TAK1) is important in satellite stem cell homeostasis and function. Inactivation... ...maintaining the pool of satellite stem cells and for regenerative myogenesis.
- Yuji Ogura
- , Sajedah M. Hindi
- , Shuichi Sato
- , Guangyan Xiong
- , Shizuo Akira
- & Ashok Kumar
Research | | Open
Histone H1-mediated epigenetic regulation controls germline stem cell self-renewal by modulating H4K16 acetylation
- ...plays critical roles in controlling stem cell self-renewal and differentiation.... ...but its role in adult stem cell regulation remains unclear. Here... ...in the regulation of germline stem cells (GSCs) in the Drosophila... ...study might be applicable to stem cells in other systems.
- Jin Sun
- , Hui-Min Wei
- , Jiang Xu
- , Jian-Feng Chang
- , Zhihao Yang
- , Xingjie Ren
- , Wen-Wen Lv
- , Lu-Ping Liu
- , Li-Xia Pan
- , Xia Wang
- , Huan-Huan Qiao
- , Bing Zhu
- , Jun-Yuan Ji
- , Dong Yan
- , Ting Xie
- , Fang-Lin Sun
- & Jian-Quan Ni
Research | | Open
Aneuploidy causes premature differentiation of neural and intestinal stem cells
- ...the number of proliferative neural stem cells (NSCs), but not... ...also present in adult intestinal stem cells but not in the wing... ...highlights a neural and intestine stem cell-specific response to aneuploidy,...
- Delphine Gogendeau
- , Katarzyna Siudeja
- , Davide Gambarotto
- , Carole Pennetier
- , Allison J. Bardin
- & Renata Basto
Research |
Tie-mediated signal from apoptotic cells protects stem cells in Drosophila melanogaster
- ...types of normal and cancer stem cells are resistant to killing by... Here we show that adult stem cells in Drosophila melanogaster germline and... DIABLO orthologue, Hid in germline stem cells. Knockdown of the IR-... ...differentiating daughter cells renders germline stem cells
- Yalan Xing
- , Tin Tin Su
- & Hannele Ruohola-Baker
Research |
The non-muscle-myosin-II heavy chain Myh9 mediates colitis-induced epithelium injury by restricting Lgr5+ stem cells
- Lgr5+ stem cells are crucial to gut epithelium... ...improve the survival of Lgr5+ stem cells and the growth of Lgr5... ...in the maintenance of Lgr5+ stem cells. As blebbistatin can mitigate... ...colitis and preserve Lgr5+ colonic stem cells in vivo, our findings...
- Bing Zhao
- , Zhen Qi
- , Yehua Li
- , Chongkai Wang
- , Wei Fu
- & Ye-Guang Chen
Research | | Open
Model of fibrolamellar hepatocellular carcinomas reveals striking enrichment in cancer stem cells
- ...is highly enriched for cancer stem cells as indicated by limited dilution... ...evidence for expression of endodermal stem cell traits. Transcriptomic analyses of... ...resembling that of biliary tree stem cells—newly discovered precursors for liver...
- Tsunekazu Oikawa
- , Eliane Wauthier
- , Timothy A. Dinh
- , Sara R. Selitsky
- , Andrea Reyna-Neyra
- , Guido Carpino
- , Ronald Levine
- , Vincenzo Cardinale
- , David Klimstra
- , Eugenio Gaudio
- , Domenico Alvaro
- , Nancy Carrasco
- , Praveen Sethupathy
- & Lola M. Reid
Research |
ASPM regulates symmetric stem cell division by tuning Cyclin E ubiquitination
- ...controlling restriction point progression and stem cell maintenance.
- Mario R. Capecchi
- & Amir Pozner
Research | | Open
Enhancer repertoires are reshaped independently of early priming and heterochromatin dynamics during B cell differentiation
- ...three developmental stages representing hematopoietic stem cells, B-cell progenitors and... ...minority of enhancers primed in stem cells or progenitors become active at...
- Mohamed-Amin Choukrallah
- , Shuang Song
- , Antonius G. Rolink
- , Lukas Burger
- & Patrick Matthias
Research | | Open
Aberrantly expressed miR-582-3p maintains lung cancer stem cell-like traits by activating Wnt/β-catenin signalling
- Cancer stem cells (CSCs) are involved in...
- Lishan Fang
- , Junchao Cai
- , Baixue Chen
- , Shanshan Wu
- , Rong Li
- , Xiaonan Xu
- , Yi Yang
- , Hongyu Guan
- , Xun Zhu
- , Le Zhang
- , Jie Yuan
- , Jueheng Wu
- & Mengfeng Li
Research |
miR-137 forms a regulatory loop with nuclear receptor TLX and LSD1 in neural stem cells
- ...role in controlling embryonic neural stem cell fate determination. miR-137... ...neural differentiation of embryonic neural stem cells. In addition, we show... ...an essential regulator of neural stem cell self-renewal, represses the... ...control the dynamics between neural stem cell
- GuoQiang Sun
- , Peng Ye
- , Kiyohito Murai
- , Ming-Fei Lang
- , Shengxiu Li
- , Heying Zhang
- , Wendong Li
- , Chelsea Fu
- , Jason Yin
- , Allen Wang
- , Xiaoxiao Ma
- & Yanhong Shi
Research | | Open
Acute loss of TET function results in aggressive myeloid cancer in mice
- ...of TET deficiency on haematopoietic stem cell (HSC) and progenitor compartments...
- Jungeun An
- , Edahí González-Avalos
- , Ashu Chawla
- , Mira Jeong
- , Isaac F. López-Moyado
- , Wei Li
- , Margaret A. Goodell
- , Lukas Chavez
- , Myunggon Ko
- & Anjana Rao
Research | | Open
Activated astrocytes enhance the dopaminergic differentiation of stem cells and promote brain repair through bFGF
- ...in DA differentiation of neural stem cells. Here we show that... DA differentiation of human embryonic stem cells (hESCs) in vitro.... ...regenerative effects of co-transplanted stem cells. Importantly, upregulation of bFGF... ...the DA differentiation of transplanted stem cells
- Fan Yang
- , Yunhui Liu
- , Jie Tu
- , Jun Wan
- , Jie Zhang
- , Bifeng Wu
- , Shanping Chen
- , Jiawei Zhou
- , Yangling Mu
- & Liping Wang
Research | | Open
Transformation of intestinal stem cells into gastric stem cells on loss of transcription factor Cdx2
- ...adult gastro-intestinal tract harbours stem cells that are responsible for the... ...day regeneration of the epithelium. Stem cells residing in the pyloric glands... ...they express. Both types of stem cells have been shown to grow... ...that single adult Lgr5-positive stem cells
- Salvatore Simmini
- , Monika Bialecka
- , Meritxell Huch
- , Lennart Kester
- , Marc van de Wetering
- , Toshiro Sato
- , Felix Beck
- , Alexander van Oudenaarden
- , Hans Clevers
- & Jacqueline Deschamps
Research | | Open
Structural and functional rejuvenation of the aged brain by an approved anti-asthmatic drug
- ...an enlargement of the neural stem cell pool, as the number...
- Julia Marschallinger
- , Iris Schäffner
- , Barbara Klein
- , Renate Gelfert
- , Francisco J. Rivera
- , Sebastian Illes
- , Lukas Grassner
- , Maximilian Janssen
- , Peter Rotheneichner
- , Claudia Schmuckermair
- , Roland Coras
- , Marta Boccazzi
- , Mansoor Chishty
- , Florian B. Lagler
- , Marija Renic
- , Hans-Christian Bauer
- , Nicolas Singewald
- , Ingmar Blümcke
- , Ulrich Bogdahn
- , Sebastien Couillard-Despres
- , D. Chichung Lie
- , Maria P. Abbracchio
- & Ludwig Aigner
Research | | Open
STAT5-regulated microRNA-193b controls haematopoietic stem and progenitor cell expansion by modulating cytokine receptor signalling
- Haematopoietic stem cells (HSCs) require the right...
- Nadine Haetscher
- , Yonatan Feuermann
- , Susanne Wingert
- , Maike Rehage
- , Frederic B. Thalheimer
- , Christian Weiser
- , Hanibal Bohnenberger
- , Klaus Jung
- , Timm Schroeder
- , Hubert Serve
- , Thomas Oellerich
- , Lothar Hennighausen
- & Michael A. Rieger
Research | | Open
Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells
- ...of transcription factor networks in stem cells by master transcription factors.
- Paulina A. Latos
- , Angela Goncalves
- , David Oxley
- , Hisham Mohammed
- , Ernest Turro
- & Myriam Hemberger
Research |
Drosophila follicle stem cells are regulated by proliferation and niche adhesion as well as mitochondria and ROS
- The mechanisms underlying adult stem cell behaviour are likely to be... ...screen using Drosophila ovarian follicle stem cells to probe essential functions regulating... ...regulating self-renewal of epithelial stem cells. Surprisingly, we find that... ...the most commonly affected essential stem cell
- Zhu A. Wang
- , Jianhua Huang
- & Daniel Kalderon
Research |
Skeletal muscle stem cells adopt a dormant cell state post mortem and retain regenerative capacity
- The accessibility to stem cells from healthy or diseased individuals... ...potency are challenging issues for stem cell biology. Here we report... ...longer beyond previous reports. Muscle stem cells are enriched in post mortem... ...of mouse muscle and haematopoietic stem cells
- Mathilde Latil
- , Pierre Rocheteau
- , Laurent Châtre
- , Serena Sanulli
- , Sylvie Mémet
- , Miria Ricchetti
- , Shahragim Tajbakhsh
- & Fabrice Chrétien
