Showing 1–25 of 532 results

  1. Research |

    • ...Here we define break-induced telomere synthesis and demonstrate that it... ...specialized replisome, which underlies ALT telomere maintenance. DNA double-strand... breaks enact nascent telomere synthesis by long-tract unidirectional... ...initial sensor of telomere damage to establish...
  2. Research |

    • Telomere dysfunction activates p53-mediated cellular... ...The broader adverse impact of telomere dysfunction across many tissues including... ...of mitochondrial physiology and metabolism, telomere dysfunction is associated with impaired... .... In the setting of telomere dysfunction, enforced Tert...
  3. Research |

  4. Research |

    • Rather than telomere-binding proteins obstructing the replication... machinery, one yeast telomere-binding protein, Taz1, is...
  5. Research |

    • ...somatic cells is limited by telomere length10. This is consistent... ...telomeric repeats can cause modest telomere lengthening in S. cerevisiae,... ...for a negative regulator of telomere length20. This negative regulator... ...moderate degrees of telomere elongation when mutationally...
  6. Special Features |

    • ...The actual terminus of a telomere is not blunt-ended but...
  7. Research |

    • ...and SIRT6 depletion leads to telomere dysfunction with end-to-end... ...SIRT6-depleted cells exhibit abnormal telomere structures that resemble defects observed... ...turn is required for proper telomere metabolism and function. Our... ...regulation by SIRT6 to telomere maintenance and a human...
  8. News and Views |

  9. Research |

    • ...that Zscan4 is involved in telomere maintenance and long-term genomic... ...state is associated with rapid telomere extension by telomere recombination and upregulation of meiosis...
  10. Research |

  11. Research |

    • Human telomere maintenance is essential for the... ...chromosome ends, and changes in telomere length have been implicated in... . Human telomere length is regulated by the... ...the duplex DNA of the telomere, it is unclear how... ...controls telomerase-mediated telomere elongation. The...
  12. Reviews |

    • Telomere length has frequently been used... ...the important property of a telomere? Here recent findings are... ...new, probabilistic view of the telomere to explain how and when...
  13. Research |

    • ...clones, each carrying a large telomere-terminal fragment of human DNA... ...DNA’ next to the molecular telomere, but are instead functional...
  14. Research |

  15. Research |

  16. Research |

  17. Research |

    • ...EWSR1 gene fusions), and telomere maintenance. In addition, our...
  18. Research |

  19. Research |

  20. Research |

    • ...and is characterized by accelerated telomere loss, genomic instability, progressive... ...as a function of progressive telomere attrition at both the cellular... ...These compound mutants showed increased telomere erosion and genomic instability,... ...deficiency and telomere dysfunction act...
  21. Research |

    • ...implications for the mechanism of telomere-telomere recombination. First, the fact... ...transformant, two independent Escherichia coli telomere clones were sequenced. In... ...of C4A DNA. Therefore, telomere-telomere recombination must require very little... ...METHODS. Telomere clones...
  22. Research |

    • ..., mrt-2, exhibits progressive telomere shortening and accumulates end-to... ...-2 protein is required for telomere replication. In addition, the... ...and then repaired by the telomere-replication enzyme telomerase.
  23. Research |

    • ...species variance are differences in telomere length and regulation. Telomeres... ...levels of telomerase lead to telomere attrition with cell division in... ...In contrast, critical reduction in telomere length is not observed in... ...provide evidence that telomere attrition in ageing telomerase...
  24. Research |

    • ...manner adjacent to a perfect telomere repeat (5′-TTAGGG-3... ...has no known function in telomere maintenance. Furthermore, transient expression... ...XR-1 cells, which disrupts telomere capping, enables telomere-associated EN
  25. Research |