Showing 1–25 of 530 results

  1. Research |

    • ...Here we define break-induced telomere synthesis and demonstrate that it... ...specialized replisome, which underlies ALT telomere maintenance. DNA double-strand... breaks enact nascent telomere synthesis by long-tract unidirectional... ...initial sensor of telomere damage to establish...
    • Robert L. Dilley
    • , Priyanka Verma
    • , Nam Woo Cho
    • , Harrison D. Winters
    • , Anne R. Wondisford
    • & Roger A. Greenberg
  2. Research |

    • ...EWSR1 gene fusions), and telomere maintenance. In addition, our...
    • Aldo Scarpa
    • , David K. Chang
    • , Katia Nones
    • , Vincenzo Corbo
    • , Ann-Marie Patch
    • , Peter Bailey
    • , Rita T. Lawlor
    • , Amber L. Johns
    • , David K. Miller
    • , Andrea Mafficini
    • , Borislav Rusev
    • , Maria Scardoni
    • , Davide Antonello
    • , Stefano Barbi
    • , Katarzyna O. Sikora
    • , Sara Cingarlini
    • , Caterina Vicentini
    • , Skye McKay
    • , Michael C. J. Quinn
    • , Timothy J. C. Bruxner
    • , Angelika N. Christ
    • , Ivon Harliwong
    • , Senel Idrisoglu
    • , Suzanne McLean
    • , Craig Nourse
    • , Ehsan Nourbakhsh
    • , Peter J. Wilson
    • , Matthew J. Anderson
    • , J. Lynn Fink
    • , Felicity Newell
    • , Nick Waddell
    • , Oliver Holmes
    • , Stephen H. Kazakoff
    • , Conrad Leonard
    • , Scott Wood
    • , Qinying Xu
    • , Shivashankar Hiriyur Nagaraj
    • , Eliana Amato
    • , Irene Dalai
    • , Samantha Bersani
    • , Ivana Cataldo
    • , Angelo P. Dei Tos
    • , Paola Capelli
    • , Maria Vittoria Davì
    • , Luca Landoni
    • , Anna Malpaga
    • , Marco Miotto
    • , Vicki L. J. Whitehall
    • , Barbara A. Leggett
    • , Janelle L. Harris
    • , Jonathan Harris
    • , Marc D. Jones
    • , Jeremy Humphris
    • , Lorraine A. Chantrill
    • , Venessa Chin
    • , Adnan M. Nagrial
    • , Marina Pajic
    • , Christopher J. Scarlett
    • , Andreia Pinho
    • , Ilse Rooman
    • , Christopher Toon
    • , Jianmin Wu
    • , Mark Pinese
    • , Mark Cowley
    • , Andrew Barbour
    • , Amanda Mawson
    • , Emily S. Humphrey
    • , Emily K. Colvin
    • , Angela Chou
    • , Jessica A. Lovell
    • , Nigel B. Jamieson
    • , Fraser Duthie
    • , Marie-Claude Gingras
    • , William E. Fisher
    • , Rebecca A. Dagg
    • , Loretta M. S. Lau
    • , Michael Lee
    • , Hilda A. Pickett
    • , Roger R. Reddel
    • , Jaswinder S. Samra
    • , James G. Kench
    • , Neil D. Merrett
    • , Krishna Epari
    • , Nam Q. Nguyen
    • , Nikolajs Zeps
    • , Massimo Falconi
    • , Michele Simbolo
    • , Giovanni Butturini
    • , George Van Buren
    • , Stefano Partelli
    • , Matteo Fassan
    • , Australian Pancreatic Cancer Genome Initiative
    • , Kum Kum Khanna
    • , Anthony J. Gill
    • , David A. Wheeler
    • , Richard A. Gibbs
    • , Elizabeth A. Musgrove
    • , Claudio Bassi
    • , Giampaolo Tortora
    • , Paolo Pederzoli
    • , Sean M. Grimmond
    • , John V. Pearson
    • , Andrew V. Biankin
    • & Nicola Waddell
  3. Research |

    • Telomere dysfunction activates p53-mediated cellular... ...The broader adverse impact of telomere dysfunction across many tissues including... ...of mitochondrial physiology and metabolism, telomere dysfunction is associated with impaired... .... In the setting of telomere dysfunction, enforced Tert...
    • Ergün Sahin
    • , Simona Colla
    • , Marc Liesa
    • , Javid Moslehi
    • , Florian L. Müller
    • , Mira Guo
    • , Marcus Cooper
    • , Darrell Kotton
    • , Attila J. Fabian
    • , Carl Walkey
    • , Richard S. Maser
    • , Giovanni Tonon
    • , Friedrich Foerster
    • , Robert Xiong
    • , Y. Alan Wang
    • , Sachet A. Shukla
    • , Mariela Jaskelioff
    • , Eric S. Martin
    • , Timothy P. Heffernan
    • , Alexei Protopopov
    • , Elena Ivanova
    • , John E. Mahoney
    • , Maria Kost-Alimova
    • , Samuel R. Perry
    • , Roderick Bronson
    • , Ronglih Liao
    • , Richard Mulligan
    • , Orian S. Shirihai
    • , Lynda Chin
    • & Ronald A. DePinho
  4. Research |

    • Rather than telomere-binding proteins obstructing the replication... machinery, one yeast telomere-binding protein, Taz1, is...
    • Kyle M. Miller
    • , Ofer Rog
    • & Julia Promisel Cooper
  5. Research |

    • ...somatic cells is limited by telomere length10. This is consistent... ...telomeric repeats can cause modest telomere lengthening in S. cerevisiae,... ...for a negative regulator of telomere length20. This negative regulator... ...moderate degrees of telomere elongation when mutationally...
    • Michael J. McEachern
    • & Elizabeth H. Blackburn
  6. Special Features |

    • ...The actual terminus of a telomere is not blunt-ended but...
    • Ramiro E. Verdun
    • & Jan Karlseder
  7. Research |

    • ...and SIRT6 depletion leads to telomere dysfunction with end-to-end... ...SIRT6-depleted cells exhibit abnormal telomere structures that resemble defects observed... ...turn is required for proper telomere metabolism and function. Our... ...regulation by SIRT6 to telomere maintenance and a human...
    • Eriko Michishita
    • , Ronald A. McCord
    • , Elisabeth Berber
    • , Mitomu Kioi
    • , Hesed Padilla-Nash
    • , Mara Damian
    • , Peggie Cheung
    • , Rika Kusumoto
    • , Tiara L. A. Kawahara
    • , J. Carl Barrett
    • , Howard Y. Chang
    • , Vilhelm A. Bohr
    • , Thomas Ried
    • , Or Gozani
    • & Katrin F. Chua
  8. News and Views |

    • Telomere maintenance in cancer cells
    • Caitlin M. Roake
    • & Steven E. Artandi
  9. Research |

    • ...that Zscan4 is involved in telomere maintenance and long-term genomic... ...state is associated with rapid telomere extension by telomere recombination and upregulation of meiosis...
    • Michal Zalzman
    • , Geppino Falco
    • , Lioudmila V. Sharova
    • , Akira Nishiyama
    • , Marshall Thomas
    • , Sung-Lim Lee
    • , Carole A. Stagg
    • , Hien G. Hoang
    • , Hsih-Te Yang
    • , Fred E. Indig
    • , Robert P. Wersto
    • & Minoru S. H. Ko
  10. Research |

    • ...inhibit telomerase activity, as other telomere binding proteins do. Instead,...
    • Huawei Xin
    • , Dan Liu
    • , Ma Wan
    • , Amin Safari
    • , Hyeung Kim
    • , Wen Sun
    • , Matthew S. O’Connor
    • & Zhou Songyang
  11. Research |

    • Human telomere maintenance is essential for the... ...chromosome ends, and changes in telomere length have been implicated in... . Human telomere length is regulated by the... ...the duplex DNA of the telomere, it is unclear how... ...controls telomerase-mediated telomere elongation. The...
    • Diego Loayza
    • & Titia de Lange
  12. Reviews |

    • Telomere length has frequently been used... ...the important property of a telomere? Here recent findings are... ...new, probabilistic view of the telomere to explain how and when...
    • Elizabeth H. Blackburn
  13. Research |

    • ...clones, each carrying a large telomere-terminal fragment of human DNA... ...DNA’ next to the molecular telomere, but are instead functional...
    • H. C. Riethman
    • , Z. Xiang
    • , S. Paul
    • , E. Morse
    • , X.-L. Hu
    • , J. Flint
    • , H.-C. Chi
    • , D. L. Grady
    • & R. K. Moyzis
  14. Research |

    • ...reporter is linked to a telomere, but not if it...
    • Derik de Bruin
    • , Zafar Zaman
    • , Rachel A. Liberatore
    • & Mark Ptashne
  15. Research |

    • ...opportunity, as exacerbation of mitotic telomere deprotection sensitizes cancer cells to...
    • Makoto T. Hayashi
    • , Anthony J. Cesare
    • , Teresa Rivera
    • & Jan Karlseder
  16. Research |

    • ...Several protective mechanisms that prevent telomere ends being recognized as a...
    • Vera Boersma
    • , Nathalie Moatti
    • , Sandra Segura-Bayona
    • , Marieke H. Peuscher
    • , Jaco van der Torre
    • , Brigitte A. Wevers
    • , Alexandre Orthwein
    • , Daniel Durocher
    • & Jacqueline J. L. Jacobs
  17. Research |

    • ...S phase, thereby keeping unrestrained telomere lengthening in check.
    • Liuh-Yow Chen
    • , Sophie Redon
    • & Joachim Lingner
  18. Research |

    • ...congenita in humans. Reprogramming restores telomere elongation in dyskeratosis congenita cells... ...(TERC) levels to restore telomere maintenance and self-renewal,...
    • Suneet Agarwal
    • , Yuin-Han Loh
    • , Erin M. McLoughlin
    • , Junjiu Huang
    • , In-Hyun Park
    • , Justine D. Miller
    • , Hongguang Huo
    • , Maja Okuka
    • , Rosana Maria dos Reis
    • , Sabine Loewer
    • , Huck-Hui Ng
    • , David L. Keefe
    • , Frederick D. Goldman
    • , Aloysius J. Klingelhutz
    • , Lin Liu
    • & George Q. Daley
  19. Research |

    • ...and is characterized by accelerated telomere loss, genomic instability, progressive... ...as a function of progressive telomere attrition at both the cellular... ...These compound mutants showed increased telomere erosion and genomic instability,... ...deficiency and telomere dysfunction act...
    • Kwok-Kin Wong
    • , Richard S. Maser
    • , Robert M. Bachoo
    • , Jayant Menon
    • , Daniel R. Carrasco
    • , Yansong Gu
    • , Frederick W. Alt
    • & Ronald A. DePinho
  20. Research |

    • ...implications for the mechanism of telomere-telomere recombination. First, the fact... ...transformant, two independent Escherichia coli telomere clones were sequenced. In... ...of C4A DNA. Therefore, telomere-telomere recombination must require very little... ...METHODS. Telomere clones...
    • Sy-Shi Wang
    • & Virginia A. Zakian
  21. Research |

    • ..., mrt-2, exhibits progressive telomere shortening and accumulates end-to... ...-2 protein is required for telomere replication. In addition, the... ...and then repaired by the telomere-replication enzyme telomerase.
    • Shawn Ahmed
    • & Jonathan Hodgkin
  22. Research |

    • ...species variance are differences in telomere length and regulation. Telomeres... ...levels of telomerase lead to telomere attrition with cell division in... ...In contrast, critical reduction in telomere length is not observed in... ...provide evidence that telomere attrition in ageing telomerase...
    • Steven E. Artandi
    • , Sandy Chang
    • , Shwu-Luan Lee
    • , Scott Alson
    • , Geoffrey J. Gottlieb
    • , Lynda Chin
    • & Ronald A. DePinho
  23. Research |

    • ...manner adjacent to a perfect telomere repeat (5′-TTAGGG-3... ...has no known function in telomere maintenance. Furthermore, transient expression... ...XR-1 cells, which disrupts telomere capping, enables telomere-associated EN
    • Tammy A. Morrish
    • , José Luis Garcia-Perez
    • , Thomas D. Stamato
    • , Guillermo E. Taccioli
    • , JoAnn Sekiguchi
    • & John V. Moran
  24. Research |

    • ...requires histone methylation and two telomere-binding proteins, Pot1 and...
    • Devanshi Jain
    • , Anna K. Hebden
    • , Toru M. Nakamura
    • , Kyle M. Miller
    • & Julia Promisel Cooper
  25. Special Features |

    • .... In particular, age-associated telomere damage, diminution of telomere 'capping' function and associated...
    • Ergün Sahin
    • & Ronald A. DePinho