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Showing 1–17 of 17 results

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Research | 21 November 2019 | Open
Proton-pump inhibitor use is associated with a broad spectrum of neurological adverse events including impaired hearing, vision, and memory
- Tigran Makunts
- , Sama Alpatty
- , Kelly C. Lee
- , Rabia S. Atayee
- & Ruben Abagyan
Scientific Reports 9 , 1–10

Rights & permissionsfor article Proton-pump inhibitor use is associated with a broad spectrum of neurological adverse events including impaired hearing, vision, and memory . Opens in a new window.
Research | 4 November 2019 | Open
Discovery of holoenzyme-disrupting chemicals as substrate-selective CK2 inhibitors
- Irina Kufareva
- , Benoit Bestgen
- , Paul Brear
- , Renaud Prudent
- , Béatrice Laudet
- , Virginie Moucadel
- , Mohamed Ettaoussi
- , Celine F. Sautel
- , Isabelle Krimm
- , Matthias Engel
- , Odile Filhol
- , Marc Le Borgne
- , Thierry Lomberget
- , Claude Cochet
- & Ruben Abagyan
Scientific Reports 9 , 1–16

Rights & permissionsfor article Discovery of holoenzyme-disrupting chemicals as substrate-selective CK2 inhibitors . Opens in a new window.
Research | 28 August 2019 | Open
Retrospective analysis reveals significant association of hypoglycemia with tramadol and methadone in contrast to other opioids
- Tigran Makunts
- , Andrew U
- , Rabia S. Atayee
- & Ruben Abagyan
Scientific Reports 9 , 1–10

Rights & permissionsfor article Retrospective analysis reveals significant association of hypoglycemia with tramadol and methadone in contrast to other opioids . Opens in a new window.
Amendments and Corrections | 5 December 2017 | Open
Publisher Correction: Population scale data reveals the antidepressant effects of ketamine and other therapeutics approved for non-psychiatric indications
Scientific Reports 7 , 1–1

Rights & permissionsfor article Publisher Correction: Population scale data reveals the antidepressant effects of ketamine and other therapeutics approved for non-psychiatric indications . Opens in a new window.
Research | 19 February 2019 | Open
Analysis of postmarketing safety data for proton-pump inhibitors reveals increased propensity for renal injury, electrolyte abnormalities, and nephrolithiasis
Scientific Reports 9 , 1–10

Rights & permissionsfor article Analysis of postmarketing safety data for proton-pump inhibitors reveals increased propensity for renal injury, electrolyte abnormalities, and nephrolithiasis . Opens in a new window.
Research | 5 December 2017 | Open
The anthelmintic praziquantel is a human serotoninergic G-protein-coupled receptor ligand
- John D. Chan
- , Pauline M. Cupit
- , Gihan S. Gunaratne
- , John D. McCorvy
- , Yang Yang
- , Kristen Stoltz
- , Thomas R. Webb
- , Peter I. Dosa
- , Bryan L. Roth
- , Ruben Abagyan
- , Charles Cunningham
- & Jonathan S. Marchant
Nature Communications 8 , 1–7

Rights & permissionsfor article The anthelmintic praziquantel is a human serotoninergic G-protein-coupled receptor ligand . Opens in a new window.
Research | 3 May 2017 | Open
Population scale data reveals the antidepressant effects of ketamine and other therapeutics approved for non-psychiatric indications
Scientific Reports 7 , 1–5

Rights & permissionsfor article Population scale data reveals the antidepressant effects of ketamine and other therapeutics approved for non-psychiatric indications . Opens in a new window.
Amendments and Corrections | 26 August 2015
Correction: Corrigendum: Lanosterol reverses protein aggregation in cataracts
- Ling Zhao
- , Xiang-Jun Chen
- , Jie Zhu
- , Yi-Bo Xi
- , Xu Yang
- , Li-Dan Hu
- , Hong Ouyang
- , Sherrina H. Patel
- , Xin Jin
- , Danni Lin
- , Frances Wu
- , Ken Flagg
- , Huimin Cai
- , Gen Li
- , Guiqun Cao
- , Ying Lin
- , Daniel Chen
- , Cindy Wen
- , Christopher Chung
- , Yandong Wang
- , Austin Qiu
- , Emily Yeh
- , Wenqiu Wang
- , Xun Hu
- , Seanna Grob
- , Ruben Abagyan
- , Zhiguang Su
- , Harry Christianto Tjondro
- , Xi-Juan Zhao
- , Hongrong Luo
- , Rui Hou
- , J. Jefferson P. Perry
- , Weiwei Gao
- , Igor Kozak
- , David Granet
- , Yingrui Li
- , Xiaodong Sun
- , Jun Wang
- , Liangfang Zhang
- , Yizhi Liu
- , Yong-Bin Yan
- & Kang Zhang
Nature 526 , 595–595

Rights & permissionsfor article Correction: Corrigendum: Lanosterol reverses protein aggregation in cataracts . Opens in a new window.
Research | 1 April 1994
Detailed ab initio prediction of lysozyme–antibody complex with 1.6 Å accuracy
- Maxim Totrov
- & Ruben Abagyan
Nature Structural & Molecular Biology 1 , 259–263

Rights & permissionsfor article Detailed ab initio prediction of lysozyme–antibody complex with 1.6 Å accuracy . Opens in a new window.
Research | 18 January 2017 | Open
Structural basis of ligand interaction with atypical chemokine receptor 3
- Martin Gustavsson
- , Liwen Wang
- , Noortje van Gils
- , Bryan S. Stephens
- , Penglie Zhang
- , Thomas J. Schall
- , Sichun Yang
- , Ruben Abagyan
- , Mark R. Chance
- , Irina Kufareva
- & Tracy M. Handel
Nature Communications 8 , 1–14

Rights & permissionsfor article Structural basis of ligand interaction with atypical chemokine receptor 3 . Opens in a new window.
Research | 19 December 2016
Orphan receptor ligand discovery by pickpocketing pharmacological neighbors
- Tony Ngo
- , Andrey V Ilatovskiy
- , Alastair G Stewart
- , James L J Coleman
- , Fiona M McRobb
- , R Peter Riek
- , Robert M Graham
- , Ruben Abagyan
- , Irina Kufareva
- & Nicola J Smith
Nature Chemical Biology 13 , 235–242

Rights & permissionsfor article Orphan receptor ligand discovery by pickpocketing pharmacological neighbors . Opens in a new window.
Research | 22 March 2016
Towards a structural understanding of allosteric drugs at the human calcium-sensing receptor
- Katie Leach
- , Karen J Gregory
- , Irina Kufareva
- , Elham Khajehali
- , Anna E Cook
- , Ruben Abagyan
- , Arthur D Conigrave
- , Patrick M Sexton
- & Arthur Christopoulos
Cell Research 26 , 574–592

Rights & permissionsfor article Towards a structural understanding of allosteric drugs at the human calcium-sensing receptor . Opens in a new window.
Research | 7 December 2016
Structure of CC chemokine receptor 2 with orthosteric and allosteric antagonists
- Yi Zheng
- , Ling Qin
- , Natalia V. Ortiz Zacarías
- , Henk de Vries
- , Gye Won Han
- , Martin Gustavsson
- , Marta Dabros
- , Chunxia Zhao
- , Robert J. Cherney
- , Percy Carter
- , Dean Stamos
- , Ruben Abagyan
- , Vadim Cherezov
- , Raymond C. Stevens
- , Adriaan P. IJzerman
- , Laura H. Heitman
- , Andrew Tebben
- , Irina Kufareva
- & Tracy M. Handel
Nature 540 , 458–461

Rights & permissionsfor article Structure of CC chemokine receptor 2 with orthosteric and allosteric antagonists . Opens in a new window.
Research | 22 July 2015
Lanosterol reverses protein aggregation in cataracts
- Ling Zhao
- , Xiang-Jun Chen
- , Jie Zhu
- , Yi-Bo Xi
- , Xu Yang
- , Li-Dan Hu
- , Hong Ouyang
- , Sherrina H. Patel
- , Xin Jin
- , Danni Lin
- , Frances Wu
- , Ken Flagg
- , Huimin Cai
- , Gen Li
- , Guiqun Cao
- , Ying Lin
- , Daniel Chen
- , Cindy Wen
- , Christopher Chung
- , Yandong Wang
- , Austin Qiu
- , Emily Yeh
- , Wenqiu Wang
- , Xun Hu
- , Seanna Grob
- , Ruben Abagyan
- , Zhiguang Su
- , Harry Christianto Tjondro
- , Xi-Juan Zhao
- , Hongrong Luo
- , Rui Hou
- , J. Jefferson
- , P. Perry
- , Weiwei Gao
- , Igor Kozak
- , David Granet
- , Yingrui Li
- , Xiaodong Sun
- , Jun Wang
- , Liangfang Zhang
- , Yizhi Liu
- , Yong-Bin Yan
- & Kang Zhang
Nature 523 , 607–611

Rights & permissionsfor article Lanosterol reverses protein aggregation in cataracts . Opens in a new window.
Research | 12 January 2016 | Open
An electrostatic mechanism for Ca²⁺-mediated regulation of gap junction channels
- Brad C. Bennett
- , Michael D. Purdy
- , Kent A. Baker
- , Chayan Acharya
- , William E. McIntire
- , Raymond C. Stevens
- , Qinghai Zhang
- , Andrew L. Harris
- , Ruben Abagyan
- & Mark Yeager
Nature Communications 7 , 1–12

Rights & permissionsfor article An electrostatic mechanism for Ca2+-mediated regulation of gap junction channels . Opens in a new window.
Reviews | 14 December 2012
The GPCR Network: a large-scale collaboration to determine human GPCR structure and function
- Raymond C. Stevens
- , Vadim Cherezov
- , Vsevolod Katritch
- , Ruben Abagyan
- , Peter Kuhn
- , Hugh Rosen
- & Kurt Wüthrich
Nature Reviews Drug Discovery 12 , 25–34

Rights & permissionsfor article The GPCR Network: a large-scale collaboration to determine human GPCR structure and function . Opens in a new window.
Research | 22 June 2011
Structure of the human histamine H₁ receptor complex with doxepin
- Tatsuro Shimamura
- , Mitsunori Shiroishi
- , Simone Weyand
- , Hirokazu Tsujimoto
- , Graeme Winter
- , Vsevolod Katritch
- , Ruben Abagyan
- , Vadim Cherezov
- , Wei Liu
- , Gye Won Han
- , Takuya Kobayashi
- , Raymond C. Stevens
- & So Iwata
Nature 475 , 65–70

Rights & permissionsfor article Structure of the human histamine H1 receptor complex with doxepin . Opens in a new window.

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