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Research | 22 November 2019 | Open
New Alzheimer’s disease model mouse specialized for analyzing the function and toxicity of intraneuronal Amyloid β oligomers
- Tomoyo Ochiishi
- , Masami Kaku
- , Kazuyuki Kiyosue
- , Motomichi Doi
- , Takao Urabe
- , Nobutaka Hattori
- , Hideki Shimura
- & Tatsuhiko Ebihara
Scientific Reports 9 , 1–15

Rights & permissionsfor article New Alzheimer’s disease model mouse specialized for analyzing the function and toxicity of intraneuronal Amyloid β oligomers . Opens in a new window.
Research | 22 November 2019 | Open
Light-driven activation of mitochondrial proton-motive force improves motor behaviors in a Drosophila model of Parkinson’s disease
Communications Biology 2 , 1–11

Rights & permissionsfor article Light-driven activation of mitochondrial proton-motive force improves motor behaviors in a Drosophila model of Parkinson’s disease . Opens in a new window.
Research | 18 September 2019 | Open
MR g-ratio-weighted connectome analysis in patients with multiple sclerosis
- Koji Kamagata
- , Andrew Zalesky
- , Kazumasa Yokoyama
- , Christina Andica
- , Akifumi Hagiwara
- , Keigo Shimoji
- , Kanako K. Kumamaru
- , Mariko Y. Takemura
- , Yasunobu Hoshino
- , Kouhei Kamiya
- , Masaaki Hori
- , Christos Pantelis
- , Nobutaka Hattori
- & Shigeki Aoki
Scientific Reports 9 , 1–13

Rights & permissionsfor article MR g-ratio-weighted connectome analysis in patients with multiple sclerosis . Opens in a new window.
Research | 5 April 2019 | Open
Multi-year whole-blood transcriptome data for the study of onset and progression of Parkinson’s Disease
Scientific Data 6 , 1–7

Rights & permissionsfor article Multi-year whole-blood transcriptome data for the study of onset and progression of Parkinson’s Disease . Opens in a new window.
Research | 31 May 2019 | Open
Gray Matter Alterations in Early and Late Relapsing-Remitting Multiple Sclerosis Evaluated with Synthetic Quantitative Magnetic Resonance Imaging
- Christina Andica
- , Akifumi Hagiwara
- , Koji Kamagata
- , Kazumasa Yokoyama
- , Keigo Shimoji
- , Asami Saito
- , Yuki Takenaka
- , Misaki Nakazawa
- , Masaaki Hori
- , Julien Cohen-Adad
- , Mariko Yoshida Takemura
- , Nobutaka Hattori
- & Shigeki Aoki
Scientific Reports 9 , 1–10

Rights & permissionsfor article Gray Matter Alterations in Early and Late Relapsing-Remitting Multiple Sclerosis Evaluated with Synthetic Quantitative Magnetic Resonance Imaging . Opens in a new window.
Research | 12 February 2018 | Open
Loss of autophagy in dopaminergic neurons causes Lewy pathology and motor dysfunction in aged mice
- Shigeto Sato
- , Toshiki Uchihara
- , Takahiro Fukuda
- , Sachiko Noda
- , Hiromi Kondo
- , Shinji Saiki
- , Masaaki Komatsu
- , Yasuo Uchiyama
- , Keiji Tanaka
- & Nobutaka Hattori
Scientific Reports 8 , 1–10

Rights & permissionsfor article Loss of autophagy in dopaminergic neurons causes Lewy pathology and motor dysfunction in aged mice . Opens in a new window.
10 July 2017
Measurements of the mitochondrial respiration and glycolytic activity in Drosophila embryonic cells
Protocol Exchange

Rights & permissionsfor article Measurements of the mitochondrial respiration and glycolytic activity in Drosophila embryonic cells . Opens in a new window.
Research | 9 June 2017 | Open
Altered humoral immunity to mycobacterial antigens in Japanese patients affected by inflammatory demyelinating diseases of the central nervous system
Scientific Reports 7 , 1–7

Rights & permissionsfor article Altered humoral immunity to mycobacterial antigens in Japanese patients affected by inflammatory demyelinating diseases of the central nervous system . Opens in a new window.
Research | 30 June 2016 | Open
Humoral response against host-mimetic homologous epitopes of Mycobacterium avium subsp. paratuberculosis in Japanese multiple sclerosis patients
Scientific Reports 6 , 1–7

Rights & permissionsfor article Humoral response against host-mimetic homologous epitopes of Mycobacterium avium subsp. paratuberculosis in Japanese multiple sclerosis patients . Opens in a new window.
News and Views | 16 July 2013
Can synucleinopathy and tauopathy be identified during life?
- Shin-ichiro Kubo
- & Nobutaka Hattori
Nature Reviews Neurology 9 , 426–427

Rights & permissionsfor article Can synucleinopathy and tauopathy be identified during life? . Opens in a new window.
Research | 28 July 2011
Comprehensive mutational analysis of LRRK2 reveals variants supporting association with autosomal dominant Parkinson's disease
- Naomi Seki
- , Yuji Takahashi
- , Hiroyuki Tomiyama
- , Ekaterina Rogaeva
- , Shigeo Murayama
- , Yoshikuni Mizuno
- , Nobutaka Hattori
- , Connie Marras
- , Anthony E Lang
- , Peter St George-Hyslop
- , Jun Goto
- & Shoji Tsuji
Journal of Human Genetics 56 , 671–675

Rights & permissionsfor article Comprehensive mutational analysis of LRRK2 reveals variants supporting association with autosomal dominant Parkinson's disease . Opens in a new window.
3 July 2009
The first total synthesis of nidulalin A, a dihydroxanthone possessing multiple bioactivities
The Journal of Antibiotics 62 , 469–470

Rights & permissionsfor article The first total synthesis of nidulalin A, a dihydroxanthone possessing multiple bioactivities . Opens in a new window.
Research | 1 July 2000
Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase
- Hideki Shimura
- , Nobutaka Hattori
- , Shin-ichiro Kubo
- , Yoshikuni Mizuno
- , Shuichi Asakawa
- , Shinsei Minoshima
- , Nobuyoshi Shimizu
- , Kazuhiro Iwai
- , Tomoki Chiba
- , Keiji Tanaka
- & Toshiaki Suzuki
Nature Genetics 25 , 302–305

Rights & permissionsfor article Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase . Opens in a new window.
Research | 16 October 2008
LRRK2 P755L variant in sporadic Parkinson’s disease
- Hiroyuki Tomiyama
- , Ikuko Mizuta
- , Yuanzhe Li
- , Manabu Funayama
- , Hiroyo Yoshino
- , Lin Li
- , Miho Murata
- , Mitsutoshi Yamamoto
- , Shin-ichiro Kubo
- , Yoshikuni Mizuno
- , Tatsushi Toda
- & Nobutaka Hattori
Journal of Human Genetics 53 , 1012–1015

Rights & permissionsfor article LRRK2 P755L variant in sporadic Parkinson’s disease . Opens in a new window.
Research | 9 April 1998
Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism
Nature 392 , 605–608

Rights & permissionsfor article Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism . Opens in a new window.
Research | 15 November 2009
Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease
- Wataru Satake
- , Yuko Nakabayashi
- , Ikuko Mizuta
- , Yushi Hirota
- , Chiyomi Ito
- , Michiaki Kubo
- , Takahisa Kawaguchi
- , Tatsuhiko Tsunoda
- , Masahiko Watanabe
- , Atsushi Takeda
- , Hiroyuki Tomiyama
- , Kenji Nakashima
- , Kazuko Hasegawa
- , Fumiya Obata
- , Takeo Yoshikawa
- , Hideshi Kawakami
- , Saburo Sakoda
- , Mitsutoshi Yamamoto
- , Nobutaka Hattori
- , Miho Murata
- , Yusuke Nakamura
- & Tatsushi Toda
Nature Genetics 41 , 1303–1307

Rights & permissionsfor article Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease . Opens in a new window.
Research | 3 March 2011
PLA2G6 variant in Parkinson's disease
- Hiroyuki Tomiyama
- , Hiroyo Yoshino
- , Kotaro Ogaki
- , Lin Li
- , Chikara Yamashita
- , Yuanzhe Li
- , Manabu Funayama
- , Ryogen Sasaki
- , Yasumasa Kokubo
- , Shigeki Kuzuhara
- & Nobutaka Hattori
Journal of Human Genetics 56 , 401–403

Rights & permissionsfor article PLA2G6 variant in Parkinson's disease . Opens in a new window.
Research | 17 May 2018 | Open
Perlecan, a heparan sulfate proteoglycan, regulates systemic metabolism with dynamic changes in adipose tissue and skeletal muscle
Scientific Reports 8 , 1–14

Rights & permissionsfor article Perlecan, a heparan sulfate proteoglycan, regulates systemic metabolism with dynamic changes in adipose tissue and skeletal muscle . Opens in a new window.
Research | 4 August 2017 | Open
Decreased long-chain acylcarnitines from insufficient β-oxidation as potential early diagnostic markers for Parkinson’s disease
- Shinji Saiki
- , Taku Hatano
- , Motoki Fujimaki
- , Kei-Ichi Ishikawa
- , Akio Mori
- , Yutaka Oji
- , Ayami Okuzumi
- , Takeshi Fukuhara
- , Takahiro Koinuma
- , Yoko Imamichi
- , Miho Nagumo
- , Norihiko Furuya
- , Shuko Nojiri
- , Taku Amo
- , Kazuo Yamashiro
- & Nobutaka Hattori
Scientific Reports 7 , 1–15

Rights & permissionsfor article Decreased long-chain acylcarnitines from insufficient β-oxidation as potential early diagnostic markers for Parkinson’s disease . Opens in a new window.
Research | 7 June 2017 | Open
Loss of Parkinson’s disease-associated protein CHCHD2 affects mitochondrial crista structure and destabilizes cytochrome c
- Hongrui Meng
- , Chikara Yamashita
- , Kahori Shiba-Fukushima
- , Tsuyoshi Inoshita
- , Manabu Funayama
- , Shigeto Sato
- , Tomohisa Hatta
- , Tohru Natsume
- , Masataka Umitsu
- , Junichi Takagi
- , Yuzuru Imai
- & Nobutaka Hattori
Nature Communications 8 , 1–18

Rights & permissionsfor article Loss of Parkinson’s disease-associated protein CHCHD2 affects mitochondrial crista structure and destabilizes cytochrome c . Opens in a new window.
Research | 14 October 2016 | Open
FUS/TLS acts as an aggregation-dependent modifier of polyglutamine disease model mice
- Yoshihiro Kino
- , Chika Washizu
- , Masaru Kurosawa
- , Mizuki Yamada
- , Hiroshi Doi
- , Toru Takumi
- , Hiroaki Adachi
- , Masahisa Katsuno
- , Gen Sobue
- , Geoffrey G. Hicks
- , Nobutaka Hattori
- , Tomomi Shimogori
- & Nobuyuki Nukina
Scientific Reports 6 , 1–14

Rights & permissionsfor article FUS/TLS acts as an aggregation-dependent modifier of polyglutamine disease model mice . Opens in a new window.
Research | 16 March 2016 | Open
Development of new fusion proteins for visualizing amyloid-β oligomers in vivo
- Tomoyo Ochiishi
- , Motomichi Doi
- , Kazuhiko Yamasaki
- , Keiko Hirose
- , Akira Kitamura
- , Takao Urabe
- , Nobutaka Hattori
- , Masataka Kinjo
- , Tatsuhiko Ebihara
- & Hideki Shimura
Scientific Reports 6 , 1–15

Rights & permissionsfor article Development of new fusion proteins for visualizing amyloid-β oligomers in vivo . Opens in a new window.
Research | 30 September 2016 | Open
Differential roles of NF-Y transcription factor in ER chaperone expression and neuronal maintenance in the CNS
- Tomoyuki Yamanaka
- , Asako Tosaki
- , Haruko Miyazaki
- , Masaru Kurosawa
- , Masato Koike
- , Yasuo Uchiyama
- , Sankar N. Maity
- , Hidemi Misawa
- , Ryosuke Takahashi
- , Tomomi Shimogori
- , Nobutaka Hattori
- & Nobuyuki Nukina
Scientific Reports 6 , 1–14

Rights & permissionsfor article Differential roles of NF-Y transcription factor in ER chaperone expression and neuronal maintenance in the CNS . Opens in a new window.
Research | 21 November 2014
Singular localization of sodium channel β4 subunit in unmyelinated fibres and its role in the striatum
- Haruko Miyazaki
- , Fumitaka Oyama
- , Ritsuko Inoue
- , Toshihiko Aosaki
- , Takaya Abe
- , Hiroshi Kiyonari
- , Yoshihiro Kino
- , Masaru Kurosawa
- , Jun Shimizu
- , Ikuo Ogiwara
- , Kazuhiro Yamakawa
- , Yoshinori Koshimizu
- , Fumino Fujiyama
- , Takeshi Kaneko
- , Hideaki Shimizu
- , Katsuhiro Nagatomo
- , Katsuya Yamada
- , Tomomi Shimogori
- , Nobutaka Hattori
- , Masami Miura
- & Nobuyuki Nukina
Nature Communications 5 , 1–15

Rights & permissionsfor article Singular localization of sodium channel β4 subunit in unmyelinated fibres and its role in the striatum . Opens in a new window.
Research | 19 December 2012 | Open
PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagy
Scientific Reports 2 , 1–8

Rights & permissionsfor article PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagy . Opens in a new window.
Research | 25 February 2014
NF-Y inactivation causes atypical neurodegeneration characterized by ubiquitin and p62 accumulation and endoplasmic reticulum disorganization
- Tomoyuki Yamanaka
- , Asako Tosaki
- , Masaru Kurosawa
- , Gen Matsumoto
- , Masato Koike
- , Yasuo Uchiyama
- , Sankar N. Maity
- , Tomomi Shimogori
- , Nobutaka Hattori
- & Nobuyuki Nukina
Nature Communications 5 , 1–15

Rights & permissionsfor article NF-Y inactivation causes atypical neurodegeneration characterized by ubiquitin and p62 accumulation and endoplasmic reticulum disorganization . Opens in a new window.
Research | 12 September 2013
YY1 binds to α-synuclein 3′-flanking region SNP and stimulates antisense noncoding RNA expression
- Ikuko Mizuta
- , Kazuaki Takafuji
- , Yuko Ando
- , Wataru Satake
- , Motoi Kanagawa
- , Kazuhiro Kobayashi
- , Shushi Nagamori
- , Takayuki Shinohara
- , Chiyomi Ito
- , Mitsutoshi Yamamoto
- , Nobutaka Hattori
- , Miho Murata
- , Yoshikatsu Kanai
- , Shigeo Murayama
- , Masanori Nakagawa
- & Tatsushi Toda
Journal of Human Genetics 58 , 711–719

Rights & permissionsfor article YY1 binds to α-synuclein 3′-flanking region SNP and stimulates antisense noncoding RNA expression . Opens in a new window.
Research | 15 October 2014 | Open
Parkin regulates kainate receptors by interacting with the GluK2 subunit
Nature Communications 5 , 1–10

Rights & permissionsfor article Parkin regulates kainate receptors by interacting with the GluK2 subunit . Opens in a new window.
Research | 21 August 2012 | Open
PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria
- Kei Okatsu
- , Toshihiko Oka
- , Masahiro Iguchi
- , Kenji Imamura
- , Hidetaka Kosako
- , Naoki Tani
- , Mayumi Kimura
- , Etsu Go
- , Fumika Koyano
- , Manabu Funayama
- , Kahori Shiba-Fukushima
- , Shigeto Sato
- , Hideaki Shimizu
- , Yuko Fukunaga
- , Hisaaki Taniguchi
- , Masaaki Komatsu
- , Nobutaka Hattori
- , Katsuyoshi Mihara
- , Keiji Tanaka
- & Noriyuki Matsuda
Nature Communications 3 , 1–10

Rights & permissionsfor article PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria . Opens in a new window.

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New Alzheimer’s disease model mouse specialized for analyzing the function and toxicity of intraneuronal Amyloid β oligomers

Light-driven activation of mitochondrial proton-motive force improves motor behaviors in a Drosophila model of Parkinson’s disease

MR g-ratio-weighted connectome analysis in patients with multiple sclerosis

Multi-year whole-blood transcriptome data for the study of onset and progression of Parkinson’s Disease

Gray Matter Alterations in Early and Late Relapsing-Remitting Multiple Sclerosis Evaluated with Synthetic Quantitative Magnetic Resonance Imaging

Loss of autophagy in dopaminergic neurons causes Lewy pathology and motor dysfunction in aged mice

Measurements of the mitochondrial respiration and glycolytic activity in Drosophila embryonic cells

Altered humoral immunity to mycobacterial antigens in Japanese patients affected by inflammatory demyelinating diseases of the central nervous system

Humoral response against host-mimetic homologous epitopes of Mycobacterium avium subsp. paratuberculosis in Japanese multiple sclerosis patients

Can synucleinopathy and tauopathy be identified during life?

Comprehensive mutational analysis of LRRK2 reveals variants supporting association with autosomal dominant Parkinson's disease

The first total synthesis of nidulalin A, a dihydroxanthone possessing multiple bioactivities

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

LRRK2 P755L variant in sporadic Parkinson’s disease

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease

PLA2G6 variant in Parkinson's disease

Perlecan, a heparan sulfate proteoglycan, regulates systemic metabolism with dynamic changes in adipose tissue and skeletal muscle

Decreased long-chain acylcarnitines from insufficient β-oxidation as potential early diagnostic markers for Parkinson’s disease

Loss of Parkinson’s disease-associated protein CHCHD2 affects mitochondrial crista structure and destabilizes cytochrome c

FUS/TLS acts as an aggregation-dependent modifier of polyglutamine disease model mice

Development of new fusion proteins for visualizing amyloid-β oligomers in vivo

Differential roles of NF-Y transcription factor in ER chaperone expression and neuronal maintenance in the CNS

Singular localization of sodium channel β4 subunit in unmyelinated fibres and its role in the striatum

PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagy

NF-Y inactivation causes atypical neurodegeneration characterized by ubiquitin and p62 accumulation and endoplasmic reticulum disorganization

YY1 binds to α-synuclein 3′-flanking region SNP and stimulates antisense noncoding RNA expression

Parkin regulates kainate receptors by interacting with the GluK2 subunit

PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria

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