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Research | 7 November 2019 | Open
Inhibition of STAT3 in tubular epithelial cells prevents kidney fibrosis and nephropathy in STZ-induced diabetic mice
- Chao Zheng
- , Lan Huang
- , Wu Luo
- , Weihui Yu
- , Xueting Hu
- , Xinfu Guan
- , Yan Cai
- , Chunpeng Zou
- , Haimin Yin
- , Zheng Xu
- , Guang Liang
- & Yi Wang
Cell Death & Disease 10 , 1–14

Rights & permissionsfor article Inhibition of STAT3 in tubular epithelial cells prevents kidney fibrosis and nephropathy in STZ-induced diabetic mice . Opens in a new window.
Research | 22 July 2019 | Open
The onset of sleep disturbances and their associations with anxiety after acute high-altitude exposure at 3700 m
- Shi-Zhu Bian
- , Laiping Zhang
- , Jun Jin
- , Ji-Hang Zhang
- , Qian-Ning Li
- , Jie Yu
- , Jian-Fei Chen
- , Shi-Yong Yu
- , Xiao-Hui Zhao
- , Jun Qin
- & Lan Huang
Translational Psychiatry 9 , 1–10

Rights & permissionsfor article The onset of sleep disturbances and their associations with anxiety after acute high-altitude exposure at 3700 m . Opens in a new window.
Research | 16 September 2019 | Open
Adipocytes promote ovarian cancer chemoresistance
- Jiang Yang
- , Munir M. Zaman
- , Iliyan Vlasakov
- , Roopali Roy
- , Lan Huang
- , Camilia R. Martin
- , Steven D. Freedman
- , Charles N. Serhan
- & Marsha A. Moses
Scientific Reports 9 , 1–12

Rights & permissionsfor article Adipocytes promote ovarian cancer chemoresistance . Opens in a new window.
Research | 24 July 2019 | Open
The role of GRHL2 and epigenetic remodeling in epithelial–mesenchymal plasticity in ovarian cancer cells
- Vin Yee Chung
- , Tuan Zea Tan
- , Jieru Ye
- , Rui-Lan Huang
- , Hung-Cheng Lai
- , Dennis Kappei
- , Heike Wollmann
- , Ernesto Guccione
- & Ruby Yun-Ju Huang
Communications Biology 2 , 1–15

Rights & permissionsfor article The role of GRHL2 and epigenetic remodeling in epithelial–mesenchymal plasticity in ovarian cancer cells . Opens in a new window.
Research | 15 July 2019
Structure of the full-length Clostridium difficile toxin B
- Peng Chen
- , Kwok-ho Lam
- , Zheng Liu
- , Frank A. Mindlin
- , Baohua Chen
- , Craig B. Gutierrez
- , Lan Huang
- , Yongrong Zhang
- , Therwa Hamza
- , Hanping Feng
- , Tsutomu Matsui
- , Mark E. Bowen
- , Kay Perry
- & Rongsheng Jin
Nature Structural & Molecular Biology 26 , 712–719

Rights & permissionsfor article Structure of the full-length <i>Clostridium difficile</i> toxin B . Opens in a new window.
Correspondence | 1 May 2006
Reply to 'Too invasive for routine use'
- Xiaohui Zhao
- & Lan Huang
Lab Animal 35 , 13–13

Rights & permissionsfor article Reply to 'Too invasive for routine use' . Opens in a new window.
Research | 24 June 2019 | Open
Paired Box-1 (PAX1) Activates Multiple Phosphatases and Inhibits Kinase Cascades in Cervical Cancer
- Po-Hsuan Su
- , Hung-Cheng Lai
- , Rui-Lan Huang
- , Lin-Yu Chen
- , Yu-Chi Wang
- , Tzu-I Wu
- , Michael W. Y. Chan
- , Chi-Chun Liao
- , Chien‐Wen Chen
- , Wei-Yu Lin
- & Cheng-Chang Chang
Scientific Reports 9 , 1–12

Rights & permissionsfor article Paired Box-1 (PAX1) Activates Multiple Phosphatases and Inhibits Kinase Cascades in Cervical Cancer . Opens in a new window.
Research | 8 December 2017 | Open
Redox-switchable breathing behavior in tetrathiafulvalene-based metal–organic frameworks
- Jian Su
- , Shuai Yuan
- , Hai-Ying Wang
- , Lan Huang
- , Jing-Yuan Ge
- , Elizabeth Joseph
- , Junsheng Qin
- , Tahir Cagin
- , Jing-Lin Zuo
- & Hong-Cai Zhou
Nature Communications 8 , 1–8

Rights & permissionsfor article Redox-switchable breathing behavior in tetrathiafulvalene-based metal–organic frameworks . Opens in a new window.
Research | 15 September 2017 | Open
Association among obesity, overweight and autism spectrum disorder: a systematic review and meta-analysis
- Zhen Zheng
- , Li Zhang
- , Shiping Li
- , Fengyan Zhao
- , Yan Wang
- , Lan Huang
- , Jinglan Huang
- , Rong Zou
- , Yi Qu
- & Dezhi Mu
Scientific Reports 7 , 1–9

Rights & permissionsfor article Association among obesity, overweight and autism spectrum disorder: a systematic review and meta-analysis . Opens in a new window.
Research | 30 January 2017 | Open
N-terminal pro-brain natriuretic peptide and cardiovascular or all-cause mortality in the general population: A meta-analysis
- Zhaohua Geng
- , Lan Huang
- , Mingbao Song
- & Yaoming Song
Scientific Reports 7 , 1–9

Rights & permissionsfor article N-terminal pro-brain natriuretic peptide and cardiovascular or all-cause mortality in the general population: A meta-analysis . Opens in a new window.
Research | 16 December 2016 | Open
Analysis of High-altitude Syndrome and the Underlying Gene Polymorphisms Associated with Acute Mountain Sickness after a Rapid Ascent to High-altitude
- Jie Yu
- , Ying Zeng
- , Guozhu Chen
- , Shizhu Bian
- , Youzhu Qiu
- , Xi Liu
- , Baida Xu
- , Pan Song
- , Jihang Zhang
- , Jun Qin
- & Lan Huang
Scientific Reports 6 , 1–10

Rights & permissionsfor article Analysis of High-altitude Syndrome and the Underlying Gene Polymorphisms Associated with Acute Mountain Sickness after a Rapid Ascent to High-altitude . Opens in a new window.
Research | 9 March 2015 | Open
Hematologic and immunological characteristics of Henoch-Schönlein purpura in rat and rabbit models induced with ovalbumin based on type III hypersensitivity
- Yanhong Li
- , Xiaochun Feng
- , Lan Huang
- , Hua Zhu
- , Yanfeng Xu
- , Xiaolong Sui
- , Yuhuan Xu
- , Yunlin Han
- & Chuan Qin
Scientific Reports 5 , 1–6

Rights & permissionsfor article Hematologic and immunological characteristics of Henoch-Schönlein purpura in rat and rabbit models induced with ovalbumin based on type III hypersensitivity . Opens in a new window.
Research | 11 January 2019 | Open
Pentatricopeptide repeat poly(A) binding protein KPAF4 stabilizes mitochondrial mRNAs in Trypanosoma brucei
- Mikhail V. Mesitov
- , Tian Yu
- , Takuma Suematsu
- , Francois M. Sement
- , Liye Zhang
- , Clinton Yu
- , Lan Huang
- & Inna Aphasizheva
Nature Communications 10 , 1–15

Rights & permissionsfor article Pentatricopeptide repeat poly(A) binding protein KPAF4 stabilizes mitochondrial mRNAs in <i>Trypanosoma brucei</i> . Opens in a new window.
Research | 25 June 2014 | Open
Spatio-temporal mapping of variation potentials in leaves of Helianthus annuus L. seedlings in situ using multi-electrode array
- Dong-Jie Zhao
- , Zhong-Yi Wang
- , Lan Huang
- , Yong-Peng Jia
- & John Q. Leng
Scientific Reports 4 , 1–7

Rights & permissionsfor article Spatio-temporal mapping of variation potentials in leaves of <i>Helianthus annuus</i> L. seedlings <i>in situ</i> using multi-electrode array . Opens in a new window.
Research | 16 February 2001
ERK phosphorylation drives cytoplasmic accumulation of hnRNP-K and inhibition of mRNA translation
- Hasem Habelhah
- , Kavita Shah
- , Lan Huang
- , Antje Ostareck-Lederer
- , A. L. Burlingame
- , Kevan M. Shokat
- , Matthias W. Hentze
- & Ze'ev Ronai
Nature Cell Biology 3 , 325–330

Rights & permissionsfor article ERK phosphorylation drives cytoplasmic accumulation of hnRNP-K and inhibition of mRNA translation . Opens in a new window.
Research | 18 October 2010
Rimonabant inhibits TNF-α-induced endothelial IL-6 secretion via CB1 receptor and cAMP-dependent protein kinase pathway
- Nan-lan Huang
- , Jyh-ming Juang
- , Yi-ho Wang
- , Chia-hsiang Hsueh
- , Yao-jen Liang
- , Jiunn-lee Lin
- , Chia-ti Tsai
- & Ling-ping Lai
Acta Pharmacologica Sinica 31 , 1447–1453

Rights & permissionsfor article Rimonabant inhibits TNF-α-induced endothelial IL-6 secretion via CB1 receptor and cAMP-dependent protein kinase pathway . Opens in a new window.
21 December 2011
Changes in the frequency and in vivo vessel-forming ability of rhesus monkey circulating endothelial colony–forming cells across the lifespan (birth to aged)
- W. Chris Shelley
- , Alyssa C. Leapley
- , Lan Huang
- , Paul J. Critser
- , Pingyu Zeng
- , Daniel Prater
- , David A. Ingram
- , Alice F. Tarantal
- & Mervin C. Yoder
Pediatric Research 71 , 156–161

Rights & permissionsfor article Changes in the frequency and <i>in vivo</i> vessel-forming ability of rhesus monkey circulating endothelial colony–forming cells across the lifespan (birth to aged) . Opens in a new window.
7 May 2010 | Open
Ediacaran Macro Body Fossils
- Timothy Huang
- , Jei-Fu Shaw
- , Liang Zheng
- , Chun-Lan Huang
- , YiLung Chang
- & ChuanWei Yang
Nature Precedings , 1–1

Rights & permissionsfor article Ediacaran Macro Body Fossils . Opens in a new window.
21 July 2009
Ag nanoparticles sensitize IR-induced killing of cancer cells
- Ruizhi Xu
- , Jun Ma
- , Xinchen Sun
- , Zhongping Chen
- , Xiaoli Jiang
- , Zhirui Guo
- , Lan Huang
- , Yang Li
- , Meng Wang
- , Changling Wang
- , Jiwei Liu
- , Xu Fan
- , Jiayu Gu
- , Xi Chen
- , Yu Zhang
- & Ning Gu
Cell Research 19 , 1031–1034

Rights & permissionsfor article Ag nanoparticles sensitize IR-induced killing of cancer cells . Opens in a new window.
Research | 1 June 1998
Structural basis for the interaction of Ras with RaIGDS
- Lan Huang
- , Franz Hofer
- , G. Steven Martin
- & Sung-Hou Kim
Nature Structural & Molecular Biology 5 , 422–426

Rights & permissionsfor article Structural basis for the interaction of Ras with RaIGDS . Opens in a new window.
6 November 2003
DNA-damaging reagents induce apoptosis through reactive oxygen species-dependent Fas aggregation
- Huey-Lan Huang
- , Li-Wen Fang
- , Shu-Ping Lu
- , Chen-Kung Chou
- , Tien-Yau Luh
- & Ming-Zong Lai
Oncogene 22 , 8168–8177

Rights & permissionsfor article DNA-damaging reagents induce apoptosis through reactive oxygen species-dependent Fas aggregation . Opens in a new window.
1 March 2006
A technique for retrograde intubation in mice
- Xiaohui Zhao
- , Nan Wu
- , Jian Zhou
- , Yongyao Yang
- , Yuqiang Fang
- , Wei Cheng
- , Ruiyan Ma
- , Ying Tian
- & Lan Huang
Lab Animal 35 , 39–42

Rights & permissionsfor article A technique for retrograde intubation in mice . Opens in a new window.
Research | 6 August 2018 | Open
Structural insights into the gating of DNA passage by the topoisomerase II DNA-gate
- Shin-Fu Chen
- , Nan-Lan Huang
- , Jung-Hsin Lin
- , Chyuan-Chuan Wu
- , Ying-Ren Wang
- , Yu-Jen Yu
- , Michael K. Gilson
- & Nei-Li Chan
Nature Communications 9 , 1–13

Rights & permissionsfor article Structural insights into the gating of DNA passage by the topoisomerase II DNA-gate . Opens in a new window.
Research | 11 June 2018 | Open
Soluble E-cadherin promotes tumor angiogenesis and localizes to exosome surface
- Maggie K. S. Tang
- , Patrick Y. K. Yue
- , Philip P. Ip
- , Rui-Lan Huang
- , Hung-Cheng Lai
- , Annie N. Y. Cheung
- , Ka Yu Tse
- , Hextan Y. S. Ngan
- & Alice S. T. Wong
Nature Communications 9 , 1–15

Rights & permissionsfor article Soluble E-cadherin promotes tumor angiogenesis and localizes to exosome surface . Opens in a new window.
Reviews | 19 March 2018 | Open
TLR-mediated metabolic reprogramming in the tumor microenvironment: potential novel strategies for cancer immunotherapy
- Lan Huang
- , Huaxi Xu
- & Guangyong Peng
Cellular & Molecular Immunology 15 , 428–437

Rights & permissionsfor article TLR-mediated metabolic reprogramming in the tumor microenvironment: potential novel strategies for cancer immunotherapy . Opens in a new window.
Research | 14 March 2018 | Open
LncFZD6 initiates Wnt/β-catenin and liver TIC self-renewal through BRG1-mediated FZD6 transcriptional activation
- Zhenzhen Chen
- , Yanfeng Gao
- , Lintong Yao
- , Yating Liu
- , Lan Huang
- , Zhongyi Yan
- , Wenshan Zhao
- , Pingping Zhu
- & Haibo Weng
Oncogene 37 , 3098–3112

Rights & permissionsfor article <i>LncFZD6</i> initiates Wnt/β-catenin and liver TIC self-renewal through BRG1-mediated FZD6 transcriptional activation . Opens in a new window.
Research | 23 February 2018 | Open
Retrosynthesis of multi-component metal−organic frameworks
- Shuai Yuan
- , Jun-Sheng Qin
- , Jialuo Li
- , Lan Huang
- , Liang Feng
- , Yu Fang
- , Christina Lollar
- , Jiandong Pang
- , Liangliang Zhang
- , Di Sun
- , Ali Alsalme
- , Tahir Cagin
- & Hong-Cai Zhou
Nature Communications 9 , 1–11

Rights & permissionsfor article Retrosynthesis of multi-component metal−organic frameworks . Opens in a new window.
Research | 25 May 2017 | Open
Construction of hierarchically porous metal–organic frameworks through linker labilization
- Shuai Yuan
- , Lanfang Zou
- , Jun-Sheng Qin
- , Jialuo Li
- , Lan Huang
- , Liang Feng
- , Xuan Wang
- , Mathieu Bosch
- , Ali Alsalme
- , Tahir Cagin
- & Hong-Cai Zhou
Nature Communications 8 , 1–10

Rights & permissionsfor article Construction of hierarchically porous metal–organic frameworks through linker labilization . Opens in a new window.
Research | 17 August 2016 | Open
DNMT1-PPARγ pathway in macrophages regulates chronic inflammation and atherosclerosis development in mice
- Jie Yu
- , Youzhu Qiu
- , Jie Yang
- , Shizhu Bian
- , Guozhu Chen
- , Mengyang Deng
- , Huali Kang
- & Lan Huang
Scientific Reports 6 , 1–11

Rights & permissionsfor article DNMT1-PPARγ pathway in macrophages regulates chronic inflammation and atherosclerosis development in mice . Opens in a new window.
Research | 24 August 2016 | Open
LncSox4 promotes the self-renewal of liver tumour-initiating cells through Stat3-mediated Sox4 expression
- Zhen-zhen Chen
- , Lan Huang
- , Ya-hong Wu
- , Wen-jie Zhai
- , Ping-ping Zhu
- & Yan-feng Gao
Nature Communications 7 , 1–13

Rights & permissionsfor article <i>LncSox4</i> promotes the self-renewal of liver tumour-initiating cells through Stat3-mediated Sox4 expression . Opens in a new window.
Research | 3 September 2015 | Open
High-resolution non-contact measurement of the electrical activity of plants in situ using optical recording
- Dong-Jie Zhao
- , Yang Chen
- , Zi-Yang Wang
- , Lin Xue
- , Tong-Lin Mao
- , Yi-Min Liu
- , Zhong-Yi Wang
- & Lan Huang
Scientific Reports 5 , 1–14

Rights & permissionsfor article High-resolution non-contact measurement of the electrical activity of plants <i>in situ</i> using optical recording . Opens in a new window.
Research | 3 December 2015 | Open
Gln40 deamidation blocks structural reconfiguration and activation of SCF ubiquitin ligase complex by Nedd8
- Clinton Yu
- , Haibin Mao
- , Eric J. Novitsky
- , Xiaobo Tang
- , Scott D. Rychnovsky
- , Ning Zheng
- & Lan Huang
Nature Communications 6 , 1–12

Rights & permissionsfor article Gln40 deamidation blocks structural reconfiguration and activation of SCF ubiquitin ligase complex by Nedd8 . Opens in a new window.
Research | 13 October 2015 | Open
Three plasma metabolite signatures for diagnosing high altitude pulmonary edema
- Li Guo
- , Guangguo Tan
- , Ping Liu
- , Huijie Li
- , Lulu Tang
- , Lan Huang
- & Qian Ren
Scientific Reports 5 , 1–10

Rights & permissionsfor article Three plasma metabolite signatures for diagnosing high altitude pulmonary edema . Opens in a new window.
Research | 15 September 2015
Upregulation of GSK3β Contributes to Brain Disorders in Elderly REGγ-knockout Mice
- Yiqing Lv
- , Bo Meng
- , Hao Dong
- , Tiantian Jing
- , Nan Wu
- , Yingying Yang
- , Lan Huang
- , Robb E Moses
- , Bert W O’Malley
- , Bing Mei
- & Xiaotao Li
Neuropsychopharmacology 41 , 1340–1349

Rights & permissionsfor article Upregulation of GSK3<i>β</i> Contributes to Brain Disorders in Elderly REG<i>γ</i>-knockout Mice . Opens in a new window.
Research | 14 December 2015
Site-specific proteasome phosphorylation controls cell proliferation and tumorigenesis
- Xing Guo
- , Xiaorong Wang
- , Zhiping Wang
- , Sourav Banerjee
- , Jing Yang
- , Lan Huang
- & Jack E. Dixon
Nature Cell Biology 18 , 202–212

Rights & permissionsfor article Site-specific proteasome phosphorylation controls cell proliferation and tumorigenesis . Opens in a new window.
Research | 27 March 2012
Casein kinase 2 reverses tail-independent inactivation of kinesin-1
- Jing Xu
- , Babu J. N. Reddy
- , Preetha Anand
- , Zhanyong Shu
- , Silvia Cermelli
- , Michelle K. Mattson
- , Suvranta K. Tripathy
- , Matthew T. Hoss
- , Nikita S. James
- , Stephen J. King
- , Lan Huang
- , Lee Bardwell
- & Steven P. Gross
Nature Communications 3 , 1–12

Rights & permissionsfor article Casein kinase 2 reverses tail-independent inactivation of kinesin-1 . Opens in a new window.
Research | 11 July 2004
The mammalian retromer regulates transcytosis of the polymeric immunoglobulin receptor
- Marcel Vergés
- , Frédéric Luton
- , Carmen Gruber
- , Frank Tiemann
- , Lorri G. Reinders
- , Lan Huang
- , Alma L. Burlingame
- , Carol R. Haft
- & Keith E. Mostov
Nature Cell Biology 6 , 763–769

Rights & permissionsfor article The mammalian retromer regulates transcytosis of the polymeric immunoglobulin receptor . Opens in a new window.
Reviews | 1 May 2007
Rethinking peptide supply to MHC class I molecules
Nature Reviews Immunology 7 , 403–410

Rights & permissionsfor article Rethinking peptide supply to MHC class I molecules . Opens in a new window.
Research | 28 March 2010
The AIM2 inflammasome is critical for innate immunity to Francisella tularensis
- Teresa Fernandes-Alnemri
- , Je-Wook Yu
- , Christine Juliana
- , Leobaldo Solorzano
- , Seokwon Kang
- , Jianghong Wu
- , Pinaki Datta
- , Margaret McCormick
- , Lan Huang
- , Erin McDermott
- , Laurence Eisenlohr
- , Carlisle P Landel
- & Emad S Alnemri
Nature Immunology 11 , 385–393

Rights & permissionsfor article The AIM2 inflammasome is critical for innate immunity to <i>Francisella tularensis</i> . Opens in a new window.
Correspondence | 1 August 1997
Three-dimensional structure of the Ras-interacting domain of RalGDS
- Lan Huang
- , Xiangwei Weng
- , Franz Hofer
- , G. Steven Martin
- & Sung-Hou Kirn
Nature Structural & Molecular Biology 4 , 609–615

Rights & permissionsfor article Three-dimensional structure of the Ras-interacting domain of RalGDS . Opens in a new window.
Research | 27 June 2010
Chemical genetics screen for enhancers of rapamycin identifies a specific inhibitor of an SCF family E3 ubiquitin ligase
- Mariam Aghajan
- , Nao Jonai
- , Karin Flick
- , Fei Fu
- , Manlin Luo
- , Xiaolu Cai
- , Ikram Ouni
- , Nathan Pierce
- , Xiaobo Tang
- , Brett Lomenick
- , Robert Damoiseaux
- , Rui Hao
- , Pierre M del Moral
- , Rati Verma
- , Ying Li
- , Cheng Li
- , Kendall N Houk
- , Michael E Jung
- , Ning Zheng
- , Lan Huang
- , Raymond J Deshaies
- , Peter Kaiser
- & Jing Huang
Nature Biotechnology 28 , 738–742

Rights & permissionsfor article Chemical genetics screen for enhancers of rapamycin identifies a specific inhibitor of an SCF family E3 ubiquitin ligase . Opens in a new window.