nature.com search

Loading Filters

Showing 1–42 of 42 results

Loading Filters

Research | 27 March 2019 | Open
X-ray structures of the high-affinity copper transporter Ctr1
- Feifei Ren
- , Brandon L. Logeman
- , Xiaohui Zhang
- , Yongjian Liu
- , Dennis J. Thiele
- & Peng Yuan
Nature Communications 10 , 1–9

Rights & permissionsfor article X-ray structures of the high-affinity copper transporter Ctr1 . Opens in a new window.
Amendments and Corrections | 1 March 2017
Erratum: Clinical impact of bone marrow morphology for the diagnosis of essential thrombocythemia: comparison between the BCSH and the WHO criteria
- H Gisslinger
- , G Jeryczynski
- , B Gisslinger
- , A Wölfler
- , S Burgstaller
- , V Buxhofer-Ausch
- , M Schalling
- , M-T Krauth
- , A-I Schiefer
- , C Kornauth
- , I Simonitsch-Klupp
- , C Beham-Schmid
- , L Müllauer
- & J Thiele
Leukemia 31 , 774–775

Rights & permissionsfor article Erratum: Clinical impact of bone marrow morphology for the diagnosis of essential thrombocythemia: comparison between the BCSH and the WHO criteria . Opens in a new window.
Correspondence | 29 November 2016 | Open
Response to Harrison et al. ‘Clinically relevant differences between BCSH and WHO diagnostic criteria for ET’
- H Gisslinger
- , G Jeryczynski
- , A Wölfler
- , C Beham-Schmid
- & J Thiele
Leukemia 31 , 768–769

Rights & permissionsfor article Response to Harrison <i>et al.</i> ‘Clinically relevant differences between BCSH and WHO diagnostic criteria for ET’ . Opens in a new window.
26 November 2014
The rate of transformation from JAK2-mutated ET to PV is influenced by an accurate WHO-defined clinico-morphological diagnosis
- T Barbui
- , J Thiele
- , A Carobbio
- , A M Vannucchi
- & A Tefferi
Leukemia 29 , 992–993

Rights & permissionsfor article The rate of transformation from JAK2-mutated ET to PV is influenced by an accurate WHO-defined clinico-morphological diagnosis . Opens in a new window.
27 November 2015 | Open
Practice-relevant revision of IPSET-thrombosis based on 1019 patients with WHO-defined essential thrombocythemia
- T Barbui
- , A M Vannucchi
- , V Buxhofer-Ausch
- , V De Stefano
- , S Betti
- , A Rambaldi
- , E Rumi
- , M Ruggeri
- , F Rodeghiero
- , M L Randi
- , I Bertozzi
- , H Gisslinger
- , G Finazzi
- , A Carobbio
- , J Thiele
- , F Passamonti
- , C Falcone
- & A Tefferi
Blood Cancer Journal 5 , e369–e369

Rights & permissionsfor article Practice-relevant revision of IPSET-thrombosis based on 1019 patients with WHO-defined essential thrombocythemia . Opens in a new window.
Research | 29 December 2015 | Open
Clinical impact of bone marrow morphology for the diagnosis of essential thrombocythemia: comparison between the BCSH and the WHO criteria
- H Gisslinger
- , G Jeryczynski
- , B Gisslinger
- , A Wölfler
- , S Burgstaller
- , V Buxhofer-Ausch
- , M Schalling
- , M-T Krauth
- , A-I Schiefer
- , C Kornauth
- , I Simonitsch-Klupp
- , C Beham-Schmid
- , L Müllauer
- & J Thiele
Leukemia 30 , 1126–1132

Rights & permissionsfor article Clinical impact of bone marrow morphology for the diagnosis of essential thrombocythemia: comparison between the BCSH and the WHO criteria . Opens in a new window.
3 June 2014
Essential thrombocythemia with high hemoglobin levels according to the revised WHO classification
- T Barbui
- , J Thiele
- , H M Kvasnicka
- , A Carobbio
- , A M Vannucchi
- & A Tefferi
Leukemia 28 , 2092–2094

Rights & permissionsfor article Essential thrombocythemia with high hemoglobin levels according to the revised WHO classification . Opens in a new window.
19 December 2013
Rethinking the diagnostic criteria of polycythemia vera
- T Barbui
- , J Thiele
- , A M Vannucchi
- & A Tefferi
Leukemia 28 , 1191–1195

Rights & permissionsfor article Rethinking the diagnostic criteria of polycythemia vera . Opens in a new window.
20 January 2014
An overview on CALR and CSF3R mutations and a proposal for revision of WHO diagnostic criteria for myeloproliferative neoplasms
- A Tefferi
- , J Thiele
- , A M Vannucchi
- & T Barbui
Leukemia 28 , 1407–1413

Rights & permissionsfor article An overview on <i>CALR</i> and <i>CSF3R</i> mutations and a proposal for revision of WHO diagnostic criteria for myeloproliferative neoplasms . Opens in a new window.
3 September 2014
The importance of central pathology review in international trials: a comparison of local versus central bone marrow reticulin grading
- O Pozdnyakova
- , S Rodig
- , S Bhandarkar
- , K Wu
- , J Thiele
- & R Hasserjian
Leukemia 29 , 241–244

Rights & permissionsfor article The importance of central pathology review in international trials: a comparison of local versus central bone marrow reticulin grading . Opens in a new window.
7 March 2013
Problems and pitfalls regarding WHO-defined diagnosis of early/prefibrotic primary myelofibrosis versus essential thrombocythemia
- T Barbui
- , J Thiele
- , A M Vannucchi
- & A Tefferi
Leukemia 27 , 1953–1958

Rights & permissionsfor article Problems and pitfalls regarding WHO-defined diagnosis of early/prefibrotic primary myelofibrosis versus essential thrombocythemia . Opens in a new window.
Research | 6 June 2013 | Open
Survival and prognosis among 1545 patients with contemporary polycythemia vera: an international study
- A Tefferi
- , E Rumi
- , G Finazzi
- , H Gisslinger
- , A M Vannucchi
- , F Rodeghiero
- , M L Randi
- , R Vaidya
- , M Cazzola
- , A Rambaldi
- , B Gisslinger
- , L Pieri
- , M Ruggeri
- , I Bertozzi
- , N H Sulai
- , I Casetti
- , A Carobbio
- , G Jeryczynski
- , D R Larson
- , L Müllauer
- , A Pardanani
- , J Thiele
- , F Passamonti
- & T Barbui
Leukemia 27 , 1874–1881

Rights & permissionsfor article Survival and prognosis among 1545 patients with contemporary polycythemia vera: an international study . Opens in a new window.
1 March 2008
Assembling the pieces
- Dennis J Thiele
- & Jonathan D Gitlin
Nature Chemical Biology 4 , 145–147

Rights & permissionsfor article Assembling the pieces . Opens in a new window.
News and Views | 3 August 1998
Differentiation or Death: The View from Versailles
Cell Death and Differentiation 5 , 716–718

Rights & permissionsfor article Differentiation or Death: The View from Versailles . Opens in a new window.
30 August 2007
Proposed criteria for the diagnosis of post-polycythemia vera and post-essential thrombocythemia myelofibrosis: a consensus statement from the international working group for myelofibrosis research and treatment
- G Barosi
- , R A Mesa
- , J Thiele
- , F Cervantes
- , P J Campbell
- , S Verstovsek
- , B Dupriez
- , R L Levine
- , F Passamonti
- , J Gotlib
- , J T Reilly
- , A M Vannucchi
- , C A Hanson
- , L A Solberg
- , A Orazi
- & A Tefferi
Leukemia 22 , 437–438

Rights & permissionsfor article Proposed criteria for the diagnosis of post-polycythemia vera and post-essential thrombocythemia myelofibrosis: a consensus statement from the international working group for myelofibrosis research and treatment . Opens in a new window.
Research | 1 October 1999
Repression of the gene encoding the TGF-β type II receptor is a major target of the EWS-FLI1 oncoprotein
- Ki-Baik Hahm
- , Keuna Cho
- , Cecile Lee
- , Young-Hyuck Im
- , Jay Chang
- , Shin-Geon Choi
- , Poul H.B. Sorensen
- , Carol J. Thiele
- & Seong-Jin Kim
Nature Genetics 23 , 222–227

Rights & permissionsfor article Repression of the gene encoding the TGF-β type II receptor is a major target of the EWS-FLI1 oncoprotein . Opens in a new window.
Research | 31 January 1985
Decreased expression of N-myc precedes retinoic acid-induced morphological differentiation of human neuroblastoma
Nature 313 , 404–406

Rights & permissionsfor article Decreased expression of N-<i>myc</i> precedes retinoic acid-induced morphological differentiation of human neuroblastoma . Opens in a new window.
1 July 1998
p27^Kip1: a key mediator of retinoic acid induced growth arrest in the SMS–KCNR human neuroblastoma cell line
- Tatsuya Matsuo
- & Carol J Thiele
Oncogene 16 , 3337–3343

Rights & permissionsfor article p27<sup>Kip1</sup>: a key mediator of retinoic acid induced growth arrest in the SMS–KCNR human neuroblastoma cell line . Opens in a new window.
News and Views | 28 September 2000
Differentiate or Die: the View from Montreal
- C J Thiele
- , S Gore
- , S Collins
- , S Waxman
- & W Miller
Cell Death and Differentiation 7 , 1014–1017

Rights & permissionsfor article Differentiate or Die: the View from Montreal . Opens in a new window.
22 December 2003
NGF activation of TrkA decreases N-myc expression via MAPK path leading to a decrease in neuroblastoma cell number
Oncogene 23 , 1522–1530

Rights & permissionsfor article NGF activation of TrkA decreases N-myc expression via MAPK path leading to a decrease in neuroblastoma cell number . Opens in a new window.
3 November 1999
Initial (prefibrotic) stages of idiopathic (primary) myelofibrosis (IMF) – a clinicopathological study
- J Thiele
- , HM Kvasnicka
- , B Boeltken
- , R Zankovich
- , V Diehl
- & R Fischer
Leukemia 13 , 1741–1748

Rights & permissionsfor article Initial (prefibrotic) stages of idiopathic (primary) myelofibrosis (IMF) – a clinicopathological study . Opens in a new window.
4 August 2000
Erythropoietic reconstitution, macrophages and reticulin fibrosis in bone marrow specimens of CML patients following allogeneic transplantation
- J Thiele
- , HM Kvasnicka
- , DW Beelen
- , B Pilgram
- , A Rose
- , L-D Leder
- & UW Schaefer
Leukemia 14 , 1378–1385

Rights & permissionsfor article Erythropoietic reconstitution, macrophages and reticulin fibrosis in bone marrow specimens of CML patients following allogeneic transplantation . Opens in a new window.
Research | 16 September 2011
Incidence and risk factors for bleeding in 1104 patients with essential thrombocythemia or prefibrotic myelofibrosis diagnosed according to the 2008 WHO criteria
- G Finazzi
- , A Carobbio
- , J Thiele
- , F Passamonti
- , E Rumi
- , M Ruggeri
- , F Rodeghiero
- , M L Randi
- , I Bertozzi
- , A M Vannucchi
- , E Antonioli
- , H Gisslinger
- , V Buxhofer-Ausch
- , N Gangat
- , A Rambaldi
- , A Tefferi
- & T Barbui
Leukemia 26 , 716–719

Rights & permissionsfor article Incidence and risk factors for bleeding in 1104 patients with essential thrombocythemia or prefibrotic myelofibrosis diagnosed according to the 2008 WHO criteria . Opens in a new window.
Research | 20 April 2001
Reconstitution of the CD45RO⁺ and CD20⁺ lymphoid marrow population following allogeneic bone marrow transplantation for Ph⁺ CML
- J Thiele
- , HM Kvasnicka
- , DW Beelen
- , A Welter
- , S Schneider
- , LD Leder
- & UW Schaefer
Bone Marrow Transplantation 27 , 425–431

Rights & permissionsfor article Reconstitution of the CD45RO<sup>+</sup> and CD20<sup>+</sup> lymphoid marrow population following allogeneic bone marrow transplantation for Ph<sup>+</sup> CML . Opens in a new window.
Research | 28 July 2000
Relevance and dynamics of myelofibrosis regarding hematopoietic reconstitution after allogeneic bone marrow transplantation in chronic myelogenous leukemia – a single center experience on 160 patients
- J Thiele
- , HM Kvasnicka
- , DW Beelen
- , TK Zirbes
- , F Jung
- , D Reske
- , LD Leder
- & UW Schaefer
Bone Marrow Transplantation 26 , 275–281

Rights & permissionsfor article Relevance and dynamics of myelofibrosis regarding hematopoietic reconstitution after allogeneic bone marrow transplantation in chronic myelogenous leukemia – a single center experience on 160 patients . Opens in a new window.
10 March 1999
Polycythemia vera megakaryocytes but not megakaryocytes from normal controls and patients with smokers polyglobuly spontaneously express IL-6 and IL-6R and secrete IL-6
- C Wickenhauser
- , J Thiele
- , J Lorenzen
- , B Schmitz
- , S Frimpong
- , K Schramm
- , I Neumann
- , R Zankovich
- & R Fischer
Leukemia 13 , 327–334

Rights & permissionsfor article Polycythemia vera megakaryocytes but not megakaryocytes from normal controls and patients with smokers polyglobuly spontaneously express IL-6 and IL-6R and secrete IL-6 . Opens in a new window.
Reviews | 30 August 2017
Regulation of heat shock transcription factors and their roles in physiology and disease
Nature Reviews Molecular Cell Biology 19 , 4–19

Rights & permissionsfor article Regulation of heat shock transcription factors and their roles in physiology and disease . Opens in a new window.
Research | 6 February 2017 | Open
Proteome and Acetylome Analysis Identifies Novel Pathways and Targets Regulated by Perifosine in Neuroblastoma
- Xiao Gu
- , Zhongyan Hua
- , Yudi Dong
- , Yue Zhan
- , Xiaowen Zhang
- , Wei Tian
- , Zhihui Liu
- , Carol J. Thiele
- & Zhijie Li
Scientific Reports 7 , 1–13

Rights & permissionsfor article Proteome and Acetylome Analysis Identifies Novel Pathways and Targets Regulated by Perifosine in Neuroblastoma . Opens in a new window.
Research | 13 February 2017 | Open
Abnormal degradation of the neuronal stress-protective transcription factor HSF1 in Huntington’s disease
- Rocio Gomez-Pastor
- , Eileen T. Burchfiel
- , Daniel W. Neef
- , Alex M. Jaeger
- , Elisa Cabiscol
- , Spencer U. McKinstry
- , Argenia Doss
- , Alejandro Aballay
- , Donald C. Lo
- , Sergey S. Akimov
- , Christopher A. Ross
- , Cagla Eroglu
- & Dennis J. Thiele
Nature Communications 8 , 1–17

Rights & permissionsfor article Abnormal degradation of the neuronal stress-protective transcription factor HSF1 in Huntington’s disease . Opens in a new window.
Research | 6 June 2016
Identification of CASZ1 NES reveals potential mechanisms for loss of CASZ1 tumor suppressor activity in neuroblastoma
- Z Liu
- , N Lam
- , E Wang
- , R A Virden
- , B Pawel
- , E F Attiyeh
- , J M Maris
- & C J Thiele
Oncogene 36 , 97–109

Rights & permissionsfor article Identification of CASZ1 NES reveals potential mechanisms for loss of CASZ1 tumor suppressor activity in neuroblastoma . Opens in a new window.
Research | 24 November 2014
Reciprocal functions of Cryptococcus neoformans copper homeostasis machinery during pulmonary infection and meningoencephalitis
- Tian-Shu Sun
- , Xiao Ju
- , Hui-Ling Gao
- , Tao Wang
- , Dennis J. Thiele
- , Jia-Yi Li
- , Zhan-You Wang
- & Chen Ding
Nature Communications 5 , 1–13

Rights & permissionsfor article Reciprocal functions of <i>Cryptococcus neoformans</i> copper homeostasis machinery during pulmonary infection and meningoencephalitis . Opens in a new window.
14 August 2015 | Open
Rationale for revision and proposed changes of the WHO diagnostic criteria for polycythemia vera, essential thrombocythemia and primary myelofibrosis
- T Barbui
- , J Thiele
- , A M Vannucchi
- & A Tefferi
Blood Cancer Journal 5 , e337–e337

Rights & permissionsfor article Rationale for revision and proposed changes of the WHO diagnostic criteria for polycythemia vera, essential thrombocythemia and primary myelofibrosis . Opens in a new window.
Research | 4 January 2016
Structures of HSF2 reveal mechanisms for differential regulation of human heat-shock factors
Nature Structural & Molecular Biology 23 , 147–154

Rights & permissionsfor article Structures of HSF2 reveal mechanisms for differential regulation of human heat-shock factors . Opens in a new window.
Research | 9 April 2014
Copper is required for oncogenic BRAF signalling and tumorigenesis
- Donita C. Brady
- , Matthew S. Crowe
- , Michelle L. Turski
- , G. Aaron Hobbs
- , Xiaojie Yao
- , Apirat Chaikuad
- , Stefan Knapp
- , Kunhong Xiao
- , Sharon L. Campbell
- , Dennis J. Thiele
- & Christopher M. Counter
Nature 509 , 492–496

Rights & permissionsfor article Copper is required for oncogenic BRAF signalling and tumorigenesis . Opens in a new window.
Research | 19 August 2009
Genetic variation of inbreeding depression among floral and fitness traits in Silene nutans
- J Thiele
- , T Hansen
- , H R Siegismund
- & T P Hauser
Heredity 104 , 52–60

Rights & permissionsfor article Genetic variation of inbreeding depression among floral and fitness traits in <i>Silene nutans</i> . Opens in a new window.
Reviews | 1 December 2011
Heat shock transcription factor 1 as a therapeutic target in neurodegenerative diseases
Nature Reviews Drug Discovery 10 , 930–944

Rights & permissionsfor article Heat shock transcription factor 1 as a therapeutic target in neurodegenerative diseases . Opens in a new window.
21 January 2011
CASZ1, a candidate tumor-suppressor gene, suppresses neuroblastoma tumor growth through reprogramming gene expression
- Z Liu
- , X Yang
- , Z Li
- , C McMahon
- , C Sizer
- , L Barenboim-Stapleton
- , V Bliskovsky
- , B Mock
- , T Ried
- , W B London
- , J Maris
- , J Khan
- & C J Thiele
Cell Death and Differentiation 18 , 1174–1183

Rights & permissionsfor article <i>CASZ1,</i> a candidate tumor-suppressor gene, suppresses neuroblastoma tumor growth through reprogramming gene expression . Opens in a new window.
16 June 2006
Downregulation of Bim by brain-derived neurotrophic factor activation of TrkB protects neuroblastoma cells from paclitaxel but not etoposide or cisplatin-induced cell death
- Z Li
- , J Zhang
- , Z Liu
- , C-W Woo
- & C J Thiele
Cell Death and Differentiation 14 , 318–326

Rights & permissionsfor article Downregulation of Bim by brain-derived neurotrophic factor activation of TrkB protects neuroblastoma cells from paclitaxel but not etoposide or cisplatin-induced cell death . Opens in a new window.
12 September 2006 | Open
Antineoplastic effects of rosiglitazone and PPARγ transactivation in neuroblastoma cells
- I Cellai
- , S Benvenuti
- , P Luciani
- , A Galli
- , E Ceni
- , L Simi
- , S Baglioni
- , M Muratori
- , B Ottanelli
- , M Serio
- , C J Thiele
- & A Peri
British Journal of Cancer 95 , 879–888

Rights & permissionsfor article Antineoplastic effects of rosiglitazone and PPAR<i>γ</i> transactivation in neuroblastoma cells . Opens in a new window.
16 April 2003
Retinoic acid decreases targeting of p27 for degradation via an N-myc-dependent decrease in p27 phosphorylation and an N-myc-independent decrease in Skp2
- M Nakamura
- , T Matsuo
- , J Stauffer
- , L Neckers
- & C J Thiele
Cell Death and Differentiation 10 , 230–239

Rights & permissionsfor article Retinoic acid decreases targeting of p27 for degradation via an N-myc-dependent decrease in p27 phosphorylation and an N-myc-independent decrease in Skp2 . Opens in a new window.
Research | 26 May 2008
The MYCN oncogene is a direct target of miR-34a
- J S Wei
- , Y K Song
- , S Durinck
- , Q-R Chen
- , A T C Cheuk
- , P Tsang
- , Q Zhang
- , C J Thiele
- , A Slack
- , J Shohet
- & J Khan
Oncogene 27 , 5204–5213

Rights & permissionsfor article The <i>MYCN</i> oncogene is a direct target of miR-34a . Opens in a new window.
Reviews | 15 February 2008
Mechanisms for copper acquisition, distribution and regulation
Nature Chemical Biology 4 , 176–185

Rights & permissionsfor article Mechanisms for copper acquisition, distribution and regulation . Opens in a new window.