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Research | 20 November 2019 | Open
Targeting TR4 nuclear receptor with antagonist bexarotene increases docetaxel sensitivity to better suppress the metastatic castration-resistant prostate cancer progression
- Linyi Hu
- , Yin Sun
- , Jie Luo
- , Xiang He
- , Meihua Ye
- , Gonghui Li
- , Yong Zhang
- , Jian Bai
- , Dahong Zhang
- & Chawnshang Chang
Oncogene , 1–13

Rights & permissionsfor article Targeting TR4 nuclear receptor with antagonist bexarotene increases docetaxel sensitivity to better suppress the metastatic castration-resistant prostate cancer progression . Opens in a new window.
Amendments and Corrections | 2 May 2019 | Open
Correction: Neurotensin and its receptors mediate neuroendocrine transdifferentiation in prostate cancer
- Shimiao Zhu
- , Hao Tian
- , Xiaodan Niu
- , Jiang Wang
- , Xing Li
- , Ning Jiang
- , Simeng Wen
- , Xuanrong Chen
- , Shancheng Ren
- , Chuanliang Xu
- , Chawnshang Chang
- , Amilcar Flores-Morales
- , Zhiqun Shang
- , Yinghao Sun
- & Yuanjie Niu
Oncogene 38 , 4885–4885

Rights & permissionsfor article Correction: Neurotensin and its receptors mediate neuroendocrine transdifferentiation in prostate cancer . Opens in a new window.
Research | 9 September 2019 | Open
Targeting the TR4 nuclear receptor-mediated lncTASR/AXL signaling with tretinoin increases the sunitinib sensitivity to better suppress the RCC progression
- Hangchuan Shi
- , Yin Sun
- , Miao He
- , Xiong Yang
- , Michiaki Hamada
- , Tsukasa Fukunaga
- , Xiaoping Zhang
- & Chawnshang Chang
Oncogene , 1–16

Rights & permissionsfor article Targeting the TR4 nuclear receptor-mediated lncTASR/AXL signaling with tretinoin increases the sunitinib sensitivity to better suppress the RCC progression . Opens in a new window.
Research | 10 September 2019
Androgen dihydrotestosterone (DHT) promotes the bladder cancer nuclear AR-negative cell invasion via a newly identified membrane androgen receptor (mAR-SLC39A9)-mediated Gαi protein/MAPK/MMP9 intracellular signaling
- Jinbo Chen
- , Fuju Chou
- , Shuyuan Yeh
- , Zhenyu Ou
- , Chihrong Shyr
- , Chiping Huang
- , Zhendong Xiang
- , Yin Sun
- , Edward Messing
- , Xiongbing Zu
- & Chawnshang Chang
Oncogene , 1–13

Rights & permissionsfor article Androgen dihydrotestosterone (DHT) promotes the bladder cancer nuclear AR-negative cell invasion via a newly identified membrane androgen receptor (mAR-SLC39A9)-mediated Gαi protein/MAPK/MMP9 intracellular signaling . Opens in a new window.
Research | 18 April 2019 | Open
Androgen receptor regulates ASS1P3/miR-34a-5p/ASS1 signaling to promote renal cell carcinoma cell growth
- Kefeng Wang
- , Yin Sun
- , Changcheng Guo
- , Tao Liu
- , Xiang Fei
- & Chawnshang Chang
Cell Death & Disease 10 , 1–13

Rights & permissionsfor article Androgen receptor regulates ASS1P3/miR-34a-5p/ASS1 signaling to promote renal cell carcinoma cell growth . Opens in a new window.
Research | 12 June 2019 | Open
LncRNA-p21 alters the antiandrogen enzalutamide-induced prostate cancer neuroendocrine differentiation via modulating the EZH2/STAT3 signaling
- Jie Luo
- , Keliang Wang
- , Shuyuan Yeh
- , Yin Sun
- , Liang Liang
- , Yao Xiao
- , Wanhai Xu
- , Yuanjie Niu
- , Liang Cheng
- , Sankar N. Maity
- , Runze Jiang
- & Chawnshang Chang
Nature Communications 10 , 1–17

Rights & permissionsfor article LncRNA-p21 alters the antiandrogen enzalutamide-induced prostate cancer neuroendocrine differentiation via modulating the EZH2/STAT3 signaling . Opens in a new window.
Research | 15 February 2018 | Open
TR₄ nuclear receptor suppresses HCC cell invasion via downregulating the EphA2 expression
- Ren’an Jin
- , Hui Lin
- , Gonghui Li
- , Junjie Xu
- , Liang Shi
- , Chawnshang Chang
- & Xiujun Cai
Cell Death & Disease 9 , 1–13

Rights & permissionsfor article TR<sub>4</sub> nuclear receptor suppresses HCC cell invasion via downregulating the EphA2 expression . Opens in a new window.
Research | 20 March 2019 | Open
Loss of the androgen receptor suppresses intrarenal calcium oxalate crystals deposition via altering macrophage recruitment/M2 polarization with change of the miR-185-5p/CSF-1 signals
- Wei Zhu
- , Zhijian Zhao
- , Fuju Chou
- , Li Zuo
- , Tongzu Liu
- , Shuyuan Yeh
- , David Bushinsky
- , Guohua Zeng
- & Chawnshang Chang
Cell Death & Disease 10 , 1–19

Rights & permissionsfor article Loss of the androgen receptor suppresses intrarenal calcium oxalate crystals deposition via altering macrophage recruitment/M2 polarization with change of the miR-185-5p/CSF-1 signals . Opens in a new window.
Research | 15 February 2019 | Open
Neurotensin and its receptors mediate neuroendocrine transdifferentiation in prostate cancer
- Shimiao Zhu
- , Hao Tian
- , Xiaodan Niu
- , Jiang Wang
- , Xing Li
- , Ning Jiang
- , Simeng Wen
- , Xuanrong Chen
- , Shancheng Ren
- , Chuanliang Xu
- , Chawnshang Chang
- , Amilcar Flores-Morales
- , Zhiqun Shang
- , Yinghao Sun
- & Yuanjie Niu
Oncogene 38 , 4875–4884

Rights & permissionsfor article Neurotensin and its receptors mediate neuroendocrine transdifferentiation in prostate cancer . Opens in a new window.
Research | 15 January 2019 | Open
Preclinical study using circular RNA 17 and micro RNA 181c-5p to suppress the enzalutamide-resistant prostate cancer progression
- Gang Wu
- , Yin Sun
- , Zhendong Xiang
- , Keliang Wang
- , Bo Liu
- , Guangqian Xiao
- , Yuanjie Niu
- , Denglong Wu
- & Chawnshang Chang
Cell Death & Disease 10 , 1–14

Rights & permissionsfor article Preclinical study using circular RNA 17 and micro RNA 181c-5p to suppress the enzalutamide-resistant prostate cancer progression . Opens in a new window.
1 May 2005
Does androgen deprivation improve treatment outcomes in patients with low-risk and intermediate-risk prostate cancer?
Nature Reviews Clinical Oncology 2 , 236–237

Rights & permissionsfor article Does androgen deprivation improve treatment outcomes in patients with low-risk and intermediate-risk prostate cancer? . Opens in a new window.
Research | 1 December 1995
Differential regulationof glutathione S-transferase Yb1 mRNA levels in rat prostate, liver and brain by androgen
Cell Research 5 , 235–242

Rights & permissionsfor article Differential regulationof glutathione S-transferase Yb1 mRNA levels in rat prostate, liver and brain by androgen . Opens in a new window.
Research | 4 March 2007
ASC-J9 ameliorates spinal and bulbar muscular atrophy phenotype via degradation of androgen receptor
- Zhiming Yang
- , Yu-Jia Chang
- , I-Chen Yu
- , Shuyuan Yeh
- , Cheng-Chia Wu
- , Hiroshi Miyamoto
- , Diane E Merry
- , Gen Sobue
- , Lu-Min Chen
- , Shu-Shi Chang
- & Chawnshang Chang
Nature Medicine 13 , 348–353

Rights & permissionsfor article ASC-J9 ameliorates spinal and bulbar muscular atrophy phenotype via degradation of androgen receptor . Opens in a new window.
Research | 4 July 2018
TR4 nuclear receptor promotes clear cell renal cell carcinoma (ccRCC) vasculogenic mimicry (VM) formation and metastasis via altering the miR490-3p/vimentin signals
- Jian Bai
- , Shuyuan Yeh
- , Xiaofu Qiu
- , Linyi Hu
- , Jun Zeng
- , Yangke Cai
- , Li Zuo
- , Gonghui Li
- , Guosheng Yang
- & Chawnshang Chang
Oncogene 37 , 5901–5912

Rights & permissionsfor article TR4 nuclear receptor promotes clear cell renal cell carcinoma (ccRCC) vasculogenic mimicry (VM) formation and metastasis via altering the miR490-3p/vimentin signals . Opens in a new window.
Research | 23 May 2018
Estrogen receptor β promotes renal cell carcinoma progression via regulating LncRNA HOTAIR-miR-138/200c/204/217 associated CeRNA network
- Jie Ding
- , Chiuan-Ren Yeh
- , Yin Sun
- , Changyi Lin
- , Joshua Chou
- , Zhenyu Ou
- , Chawnshang Chang
- , Jun Qi
- & Shuyuan Yeh
Oncogene 37 , 5037–5053

Rights & permissionsfor article Estrogen receptor β promotes renal cell carcinoma progression via regulating LncRNA HOTAIR-miR-138/200c/204/217 associated CeRNA network . Opens in a new window.
Research | 13 October 2017 | Open
Androgen receptor increases hematogenous metastasis yet decreases lymphatic metastasis of renal cell carcinoma
- Qingbo Huang
- , Yin Sun
- , Xin Ma
- , Yu Gao
- , Xintao Li
- , Yuanjie Niu
- , Xu Zhang
- & Chawnshang Chang
Nature Communications 8 , 1–15

Rights & permissionsfor article Androgen receptor increases hematogenous metastasis yet decreases lymphatic metastasis of renal cell carcinoma . Opens in a new window.
23 June 2017
LncRNA-SARCC suppresses renal cell carcinoma (RCC) progression via altering the androgen receptor(AR)/miRNA-143-3p signals
- Wei Zhai
- , Yin Sun
- , Changcheng Guo
- , Guanghui Hu
- , Mingchao Wang
- , Jiayi Zheng
- , WanYing Lin
- , Qingbo Huang
- , Gonghui Li
- , Junhua Zheng
- & Chawnshang Chang
Cell Death and Differentiation 24 , 1502–1517

Rights & permissionsfor article LncRNA-SARCC suppresses renal cell carcinoma (RCC) progression via altering the androgen receptor(AR)/miRNA-143-3p signals . Opens in a new window.
Research | 16 September 2012
The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK
- Yan-yan Zhan
- , Yan Chen
- , Qian Zhang
- , Jia-jia Zhuang
- , Min Tian
- , Hang-zi Chen
- , Lian-ru Zhang
- , Hong-kui Zhang
- , Jian-ping He
- , Wei-jia Wang
- , Rong Wu
- , Yuan Wang
- , Chunfang Shi
- , Kai Yang
- , An-zhong Li
- , Yong-zhen Xin
- , Terytty Yang Li
- , James Y Yang
- , Zhong-hui Zheng
- , Chun-dong Yu
- , Sheng-Cai Lin
- , Chawnshang Chang
- , Pei-qiang Huang
- , Tianwei Lin
- & Qiao Wu
Nature Chemical Biology 8 , 897–904

Rights & permissionsfor article The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK . Opens in a new window.

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Targeting TR4 nuclear receptor with antagonist bexarotene increases docetaxel sensitivity to better suppress the metastatic castration-resistant prostate cancer progression

Correction: Neurotensin and its receptors mediate neuroendocrine transdifferentiation in prostate cancer

Targeting the TR4 nuclear receptor-mediated lncTASR/AXL signaling with tretinoin increases the sunitinib sensitivity to better suppress the RCC progression

Androgen dihydrotestosterone (DHT) promotes the bladder cancer nuclear AR-negative cell invasion via a newly identified membrane androgen receptor (mAR-SLC39A9)-mediated Gαi protein/MAPK/MMP9 intracellular signaling

Androgen receptor regulates ASS1P3/miR-34a-5p/ASS1 signaling to promote renal cell carcinoma cell growth

LncRNA-p21 alters the antiandrogen enzalutamide-induced prostate cancer neuroendocrine differentiation via modulating the EZH2/STAT3 signaling

TR₄ nuclear receptor suppresses HCC cell invasion via downregulating the EphA2 expression

Loss of the androgen receptor suppresses intrarenal calcium oxalate crystals deposition via altering macrophage recruitment/M2 polarization with change of the miR-185-5p/CSF-1 signals

Neurotensin and its receptors mediate neuroendocrine transdifferentiation in prostate cancer

Preclinical study using circular RNA 17 and micro RNA 181c-5p to suppress the enzalutamide-resistant prostate cancer progression

Does androgen deprivation improve treatment outcomes in patients with low-risk and intermediate-risk prostate cancer?

Differential regulationof glutathione S-transferase Yb1 mRNA levels in rat prostate, liver and brain by androgen

ASC-J9 ameliorates spinal and bulbar muscular atrophy phenotype via degradation of androgen receptor

TR4 nuclear receptor promotes clear cell renal cell carcinoma (ccRCC) vasculogenic mimicry (VM) formation and metastasis via altering the miR490-3p/vimentin signals

Estrogen receptor β promotes renal cell carcinoma progression via regulating LncRNA HOTAIR-miR-138/200c/204/217 associated CeRNA network

Androgen receptor increases hematogenous metastasis yet decreases lymphatic metastasis of renal cell carcinoma

LncRNA-SARCC suppresses renal cell carcinoma (RCC) progression via altering the androgen receptor(AR)/miRNA-143-3p signals

The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK

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