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Research | 29 July 2019 | Open
ER-residential Nogo-B accelerates NAFLD-associated HCC mediated by metabolic reprogramming of oxLDL lipophagy
- Yuan Tian
- , Bin Yang
- , Weinan Qiu
- , Yajing Hao
- , Zhenxing Zhang
- , Bo Yang
- , Nan Li
- , Shuqun Cheng
- , Zhangjun Lin
- , Yao-cheng Rui
- , Otto K. W. Cheung
- , Weiqin Yang
- , William K. K. Wu
- , Yue-Sun Cheung
- , Paul B. S. Lai
- , Jianjun Luo
- , Joseph J. Y. Sung
- , Runsheng Chen
- , Hong-Yang Wang
- , Alfred S. L. Cheng
- & Pengyuan Yang
Nature Communications 10 , 1–16

Rights & permissionsfor article ER-residential Nogo-B accelerates NAFLD-associated HCC mediated by metabolic reprogramming of oxLDL lipophagy . Opens in a new window.
Research | 6 December 2018 | Open
An inflammatory-CCRK circuitry drives mTORC1-dependent metabolic and immunosuppressive reprogramming in obesity-associated hepatocellular carcinoma
- Hanyong Sun
- , Weiqin Yang
- , Yuan Tian
- , Xuezhen Zeng
- , Jingying Zhou
- , Myth T. S. Mok
- , Wenshu Tang
- , Yu Feng
- , Liangliang Xu
- , Anthony W. H. Chan
- , Joanna H. Tong
- , Yue-Sun Cheung
- , Paul B. S. Lai
- , Hector K. S. Wang
- , Shun-Wa Tsang
- , King-Lau Chow
- , Mengying Hu
- , Rihe Liu
- , Leaf Huang
- , Bing Yang
- , Pengyuan Yang
- , Ka-Fai To
- , Joseph J. Y. Sung
- , Grace L. H. Wong
- , Vincent W. S. Wong
- & Alfred S. L. Cheng
Nature Communications 9 , 1–16

Rights & permissionsfor article An inflammatory-CCRK circuitry drives mTORC1-dependent metabolic and immunosuppressive reprogramming in obesity-associated hepatocellular carcinoma . Opens in a new window.
Research | 25 June 2004
Expression of HBx and COX-2 in chronic hepatitis B, cirrhosis and hepatocellular carcinoma: implication of HBx in upregulation of COX-2
- Alfred S-L Cheng
- , Henry L-Y Chan
- , Wai K Leung
- , Ka F To
- , Minnie Y-Y Go
- , John Y-H Chan
- , Choong T Liew
- & Joseph J-Y Sung
Modern Pathology 17 , 1169–1179

Rights & permissionsfor article Expression of HBx and COX-2 in chronic hepatitis B, cirrhosis and hepatocellular carcinoma: implication of HBx in upregulation of COX-2 . Opens in a new window.
Research | 6 August 2018 | Open
FGF18, a prominent player in FGF signaling, promotes gastric tumorigenesis through autocrine manner and is negatively regulated by miR-590-5p
- Jinglin Zhang
- , Yuhang Zhou
- , Tingting Huang
- , Feng Wu
- , Yi Pan
- , Yujuan Dong
- , Yan Wang
- , Aden K. Y. Chan
- , Liping Liu
- , Johnny S. H. Kwan
- , Alvin H. K. Cheung
- , Chi Chun Wong
- , Angela K. F. Lo
- , Alfred S. L. Cheng
- , Jun Yu
- , Kwok Wai Lo
- , Wei Kang
- & Ka Fai To
Oncogene 38 , 33–46

Rights & permissionsfor article FGF18, a prominent player in FGF signaling, promotes gastric tumorigenesis through autocrine manner and is negatively regulated by miR-590-5p . Opens in a new window.
Research | 24 January 2018 | Open
miR-375 is involved in Hippo pathway by targeting YAP1/TEAD4-CTGF axis in gastric carcinogenesis
- Wei Kang
- , Tingting Huang
- , Yuhang Zhou
- , Jinglin Zhang
- , Raymond W. M. Lung
- , Joanna H. M. Tong
- , Anthony W. H. Chan
- , Bin Zhang
- , Chi Chun Wong
- , Feng Wu
- , Yujuan Dong
- , Shiyan Wang
- , Weiqin Yang
- , Yi Pan
- , Wing Po Chak
- , Alvin H. K. Cheung
- , Jesse C. S. Pang
- , Jun Yu
- , Alfred S. L. Cheng
- & Ka Fai To
Cell Death & Disease 9 , 1–16

Rights & permissionsfor article miR-375 is involved in Hippo pathway by targeting YAP1/TEAD4-CTGF axis in gastric carcinogenesis . Opens in a new window.
Research | 13 December 2017 | Open
SRGAP1, a crucial target of miR-340 and miR-124, functions as a potential oncogene in gastric tumorigenesis
- Tingting Huang
- , Yuhang Zhou
- , Jinglin Zhang
- , Chi Chun Wong
- , Weilin Li
- , Johnny S. H. Kwan
- , Rui Yang
- , Aden K. Y. Chan
- , Yujuan Dong
- , Feng Wu
- , Bin Zhang
- , Alvin H. K. Cheung
- , William K. K. Wu
- , Alfred S. L. Cheng
- , Jun Yu
- , Nathalie Wong
- , Wei Kang
- & Ka Fai To
Oncogene 37 , 1159–1174

Rights & permissionsfor article SRGAP1, a crucial target of miR-340 and miR-124, functions as a potential oncogene in gastric tumorigenesis . Opens in a new window.
Research | 4 September 2017
Reconstruction of enhancer–target networks in 935 samples of human primary cells, tissues and cell lines
- Qin Cao
- , Christine Anyansi
- , Xihao Hu
- , Liangliang Xu
- , Lei Xiong
- , Wenshu Tang
- , Myth T S Mok
- , Chao Cheng
- , Xiaodan Fan
- , Mark Gerstein
- , Alfred S L Cheng
- & Kevin Y Yip
Nature Genetics 49 , 1428–1436

Rights & permissionsfor article Reconstruction of enhancer–target networks in 935 samples of human primary cells, tissues and cell lines . Opens in a new window.
Research | 16 August 2016 | Open
Epigenetic silencing of the NR4A3 tumor suppressor, by aberrant JAK/STAT signaling, predicts prognosis in gastric cancer
- Chung-Min Yeh
- , Liang-Yu Chang
- , Shu-Hui Lin
- , Jian-Liang Chou
- , Hsiao-Yen Hsieh
- , Li-Han Zeng
- , Sheng-Yu Chuang
- , Hsiao-Wen Wang
- , Claudia Dittner
- , Cheng-Yu Lin
- , Jora M. J. Lin
- , Yao-Ting Huang
- , Enders K. W. Ng
- , Alfred S. L. Cheng
- , Shu-Fen Wu
- , Jiayuh Lin
- , Kun-Tu Yeh
- & Michael W. Y. Chan
Scientific Reports 6 , 1–13

Rights & permissionsfor article Epigenetic silencing of the <i>NR4A3</i> tumor suppressor, by aberrant JAK/STAT signaling, predicts prognosis in gastric cancer . Opens in a new window.

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