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Epigenetics Fundamentals

What Is Epigenetics?

If all cells are created from the same genetic material, why are there so many different cell types? Listen to Sriharsa Pradhan, Research Division Head, RNA Biology at NEB, as he describes how DNA is methylated and how this affects the path of reading the DNA code the same way an obstruction would derail a train off its tracks.

How Complex Is Epigenetics?

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Epigenetic changes to DNA impact a wide range of biological processes such as organism development and disease progression. Watch as Sriharsa enthusiastically describes this exciting and complex field that has the power to "re-write" the course of DNA transcription.

How Can Epigenetics Help Us Treat Diseases?

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Cancer cells have epigenetic changes to their DNA. One of these causes the turning off (silencing) of tumor suppressor genes, a small set of genes involved in cell cycle control. Sriharsa discusses drugs currently in the clinic that are able to demethylate DNA and improve the lives of cancer patients.

What Does Epigenetics Have to Do with Honeybees?

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Rick Feehery, Research Associate at New England Biolabs, Inc, explains the mechanisms of epigenetic DNA modification. To drive home the power of such tiny changes, he uses the example of honeybee colonies, wherein DNA methylation is the only factor that determines whether a bee is born a worker, drone or queen.

New discoveries in epigenetics are popping up every week. See how an online social network allows scientists to exchange ideas and discuss trends: www.epiexperts.com (Hosted by New England BioLabs.)