Visualization of chromosomal bridges in Allium fistulosum and Allium cepa (plant) meiocytes
The sites of double-stranded break (DSB) dependent homologue interaction can be seen as approximately 400 nm bridges between chromosome axes. These bridges, which probably contain a DSB that is already engaged in a nascent interaction with its partner DNA, occur in large numbers. Their formation depends on the RecA (recombination protein) homologues that are expressed in this species. In the next phase of homologue interaction, these nascent interactions are converted to stable strand-invasion events. This nucleates the formation of the synaptonemal complex (SC).
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How is the same process responsible for genetic recombination and diversity also the cause of aneuploidy? Understanding the steps of meiosis is essential to learning how errors occur.
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