Two models of chromosome organization.
- Author: T. C. Cramer
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Two models of chromosome organization.
A) The chromosome territory model. B) The spaghetti model. The two models make distinct predictions when tested in a marking experiment. Upon marking of a nuclear subvolume, model A predicts marking of a small subset of chromosomes, model B marking of many. These models were tested by irradiating a subsection of the nucleus using a microlaser and mapping of damaged regions in subsequent mitosis.
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Chromosomes occupy specific regions of a nucleus, called "chromosome territories." These subdomains might be doing much more than just keeping everything organized.
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