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Two-hit tumor formation in both hereditary and nonhereditary retinoblastoma.

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Two-hit tumor formation in both hereditary and nonhereditary retinoblastoma.
Whereas a "one-hit" clone is a precursor to the tumor in nonhereditary retinoblastomas, all retinoblasts (indeed, all cells) are one-hit clones in hereditary retinoblastoma.

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Tumor Suppressor (TS) Genes and the Two-Hit Hypothesis

Tumor suppressor genes act as “brakes” to stop cells before they can travel down the road to cancer. A loss of function mutation in these genes can be disastrous.

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