The relationships of G proteins to the plasma membrane
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The relationships of G proteins to the plasma membrane
In this diagram of G-protein-coupled receptor activation, the alpha, beta, and gamma subunits are shown with distinct relationships to the plasma membrane. After exchange of GDP with GTP on the alpha subunit, both the alpha subunit and the beta-gamma complex may interact with other molecules to promote signaling cascades. Note that both the alpha subunit and the beta-gamma complex remain tethered to the plasma membrane while they are activated. These activated subunits can act on ion channels in the cell membrane, as well as cellular enzymes and second messenger molecules that travel around the cell.
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The large family of G-protein-coupled receptors (GPCRs) contains a diverse group of membrane-bound signaling molecules. Learn how activated GPCRs relay messages by heterotrimeric GTP-binding proteins.
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