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The mammalian mitofusin Mfn2 tethers mitochondria to the endoplasmic reticulum (ER)


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The mammalian mitofusin Mfn2 tethers mitochondria to the endoplasmic reticulum (ER)
Three-dimensional reconstruction of mitochondria (orange) and ER (cyan) complexes based on electron tomography of mouse cells. In wild-type cells (top), mitochondria and ER are very closely apposed. In mutant cells lacking Mfn2 (bottom), the mitochondria-ER association is disrupted.

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Mitchondria are in a constant state of fusion and division inside the cell. Learn how this organelle is not just a passively floating ovoid structure.

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