The mammalian mitofusin Mfn2 tethers mitochondria to the endoplasmic reticulum (ER)
Three-dimensional reconstruction of mitochondria (orange) and ER (cyan) complexes based on electron tomography of mouse cells. In wild-type cells (top), mitochondria and ER are very closely apposed. In mutant cells lacking Mfn2 (bottom), the mitochondria-ER association is disrupted.
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