The energetic funnel
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The energetic funnel
Proteins fold into their correct minimal-energy configuration because of the physicochemical properties of their amino acid sequence. Proteins fold rapidly because amino acids interact locally, thus limiting the conformational space that the protein has to explore and forcing the protein to follow a funnel-like energy landscape that allows it to fold quickly.
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An error in protein conformation can lead to disease. What are the genetic and molecular causes for incorrectly formed proteins?
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