Single-stranded DNA (ssDNA) at the stalled replication fork
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Single-stranded DNA (ssDNA) at the stalled replication fork
(A) RFs slow and then stall during HU treatment, generating ssDNA. (B) This ssDNA is a signal that resembles DNA damage from resected DNA DSBs or single-strand repair patches. (C) ssDNA is also generated at telomeres and is a signal of telomere instability. A common feature in all of these structures is the presence of ssDNA, which causes ATR activation to promote RF stalling, DNA repair, and cell cycle stalling. Thus, ssDNA is a potent signal that links DNA damage to repair.
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At a stalled DNA replication fork, how is replication restarted after DNA damage has been resolved?
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