Secondary structure alternatives in the trp leader transcript.
On the left are the two base-paired structures that are detected in vitro. The arrows indicate the sites of RNase TI attack. The G-bonds in the hydrogen-bonded regions are not cleaved, presumably because the Gs are base paired. On the right is an alternative secondary structure. Formation of this structure is thought to prevent transcription termination at the attenuator. For simplicity we designate the transcript segments that participate in these hydrogen-bonded structures strands 1–4 (see center insert). The trp codons are in strand 1. The trpL75 mutation is indicated.
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