Relationships in ZFA and GO ontologies

(A) A subset of the organs of the zebrafish represented in the ZFA ontology. Each of the organs — heart, gill, and brain — is related to the general parent term organ by an is_a relationship. Several parts of the brain are also indicated. The relationships is_a, part_of, and develops_from are used. The inferred develops_from relationship between brain and ectoderm is shown. An incorrectly inferred relationship is shown with an [x]. (B) In the GO biological process ontology, the process of M phase is comprised of parts, such as prophase, anaphase, etc. One of the inferred part_of relationships, between telophase and cell cycle, is indicated. Four worm (C. elegans) genes have been annotated to the anaphase process, and are indicated here. Counts of worm genes annotated to each node are indicated in parentheses. Transitive relationships allow annotations to child nodes to be propagated [up] to the parent nodes. (See Figure 2 for more statistics.) Is_a relationships are represented by red (round [i]) arrows, part_of relationships by blue (square [p]) arrows, and develops_from by green (diamond [D]) arrows. Inferred relationships are indicated by dotted lines. Only a portion of the ontology terms and their relationships are represented here for clarity and brevity. To view the biological process ontology, visit http://amigo.geneontology.org/cgi-bin/amigo/browse.cgi. To view the zebrafish anatomy (ZFA) ontology, visit http://www.ebi.ac.uk/ontology-lookup/browse.do?ontName=ZDB.