Phosphorylation modification in signaling pathway
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Phosphorylation modification in signaling pathway
(A) Illustrates the general model. Protein1 is phosphorylated by kinase1, and is subsequently recognized by protein 2 which contains the phosphopeptide binding domain. The assembly or disassembly of protein complexes takes place in spatiotemporal manner within the cell, leading to switching the signaling pathways on or off. (B) Illustrates a specific example. During mitosis, Plk1 phosphorylates Nedd1 at several sites, which is further recognized by γ-tubulin. The complex of Nedd1 and γ-tubulin together localizes to the centrosome and enhances the microtubule nucleation around the centrosome.
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What regulates protein kinase activity during cell division? Interestingly, protein kinases phosphorylate each other as well as act on common targets.
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