Kinetochore organization

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Kinetochore organization

The kinetochore can be thought of as three sets of subcomponents: (a) The chromosomal DNA-inner kinetochore protein interface (further details of this interface are shown in Figure 4), (b) the inner kinetochore-mitotic spindle interface, and (c) the kinetochore protein-cell cycle machinery interface. (APC = anaphase-promoting complex, CEN = centromeric DNA, and SCF = Skp, Cullin, F-box-containing ubiquitin-ligase complex.)

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Chromosome Segregation in Mitosis: The Role of Centromeres

Without centromeres, cells cannot divide properly and the overall process of mitosis fails. Why are these small chromosomal regions so essential to such a major cellular process?