Footprint patterns of mice with normal and abnormal ephrin-B3

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Footprint patterns of mice with normal and abnormal ephrin-B3

Paw prints of mice show defects in development caused by a mutation in ephrin-B3. Paws were marked with paint, and mice walked across a platform. On the left, a normal pattern of asymmetric steps was made by a wild-type mouse. On the right, an ephrin-B3 knockout mouse (ephrin-B3 KO) showed a different pattern. Whereas the wild-type animal shows normal alternate steps while walking, the ephrin-B3 knockout mouse moves with a symmetrical hopping pattern (hind legs are always paired). This walking pattern reflects the abnormal development of the mouse's neurons controlling its hind legs.

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