Expression of the XIST gene in males, females, and somatic cell hybrids.
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Expression of the XIST gene in males, females, and somatic cell hybrids.
Slot blot of total cellular RNA isolated from human lymphoblastoid cell lines or mouse-human somatic cell hybrids retaining either the active or inactive human X chromosome, hybridized with the 14A XIST cDNA probe. The probe hybridizes only to RNA samples from cell lines which contain an inactive X chromosome.
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Transcriptionally “silent” Barr bodies maintain gene equality in male (XY) and female (XX) cells. How are these unique sex chromosomes formed?
Females (XX) carry twice as many X-linked genes on their sex chromosomes as males (XY). How do cells control gene expression to manage this potentially lethal dosage problem?
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