DNA footprinting reveals transcription factor specificity in different cell types
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DNA footprinting reveals transcription factor specificity in different cell types
In vivo footprinting analysis of the human beta globin promoter shows that adult erythroblasts (E, lane 4) have footprints on important regulatory motifs (note lighter regions, especially at CACC) as compared to the other samples. Here, lane N is control DNA, lane H is HeLa cells, lane K is K562 cells, lane R is Raji cells, and lane J is Jurkat cells. Of these cells lines, none is part of the lineage leading to red blood cells.
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If our genes are so similar, what really makes a eukaryote different from a prokaryote, or a human from E. coli? The answer lies in the difference in gene expression and regulation used.
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