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Disruption of intracellular signalling by alterations in the cancer genome.

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Disruption of intracellular signalling by alterations in the cancer genome.
A simplified signaling pathway is depicted to highlight known examples of bona fide oncogenes that are subjected to dysregulation by various mechanisms. It is clear that a signaling pathway can be disrupted at multiple points, and a variety of genomic and epigenomic alterations can contribute to this, ultimately leading to cancer.

This image is linked to the following Scitable pages:

Proto-oncogenes to Oncogenes to Cancer

What drives cancer cells to grow and divide uncontrollably turning into cancer? Studies of proto-oncogenes reveal some clues about how normal cellular processes mutate and go awry.

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