Dimerization of ERBB receptors with kinase domains lined up asymmetrically as ERBB3 is shown activating ERBB2
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Dimerization of ERBB receptors with kinase domains lined up asymmetrically as ERBB3 is shown activating ERBB2
Because ERBB2 binds no known ligand, only ERBB3 is shown with ligand bound. This activation leads to phosphorylation of specific tyrosines in the tail region of the receptors, activation of downstream proteins, and various cellular outcomes.
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The ERBB receptors are a group of receptor tyrosine kinases (RTKs) involved in key cellular functions including cell growth and survival. What are the activation mechanisms particular to ERBBs?
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