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Comparative Methylation Hybridization experimental design.

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Comparative Methylation Hybridization experimental design.
In the right panel, vertical bars represent the restriction enzyme recognition sites of Sma I and Xma I (5’-CCCGGG-3’). In the DNA segment shown, the control sample is methylated at only two of the six sites, while the disease (test) sample is methylated at three.

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Comparative Methylation Hybridization

How do complex adult-onset disorders take place? The methylation of DNA sequences is an important component of epigenetic control that can be inherited or occur over time.

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